Results 71 to 80 of about 4,769,883 (431)

The apo LETM1 F‐EF‐hand adopts a closed conformation that underlies a multi‐modal sensory role in mitochondria

FEBS Letters, Volume 599, Issue 7, Page 971-988, April 2025.
We present the first solution structure of the Ca2+‐depleted LETM1 F‐EF‐hand through a D676A/N678A Ca2+ binding‐deficient mutant, revealing a closed hydrophobic cleft caused by a unique F1‐helix pivot. The apo LETM1 F‐EF‐hand exhibits regiospecific hot and cold unfolding, sensitivity to physiological pH changes and potential for promiscuous heterotypic
Qi‐Tong Lin, Danielle M. Colussi, Peter B. Stathopulos   +2 more
wiley   +1 more source

PDGFRα plays a crucial role in connective tissue remodeling

Scientific Reports, 2015
Platelet derived growth factor (PDGF) plays a pivotal role in the remodeling of connective tissues. Emerging data indicate the distinctive role of PDGF receptor-α (PDGFRα) in this process.
Shinjiro Horikawa, Y. Ishii, T. Hamashima, Seiji Yamamoto, H. Mori, T. Fujimori, Jie Shen, Ran Inoue, H. Nishizono, H. Itoh, M. Majima, D. Abraham, T. Miyawaki, M. Sasahara   +13 more
semanticscholar   +1 more source

Distinct dysregulated pathways in sporadic and Lynch syndrome‐associated colorectal cancer offer insights for targeted treatment

FEBS Letters, Volume 599, Issue 7, Page 1006-1028, April 2025.
This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause, Musalula Sinkala, Raj Ramesar   +2 more
wiley   +1 more source

Challenging in leprosy relapse with antiphospholipid syndrome diagnosis: A case report

Clinical Case Reports
Key Clinical Message Infectious diseases like leprosy can cause antiphospholipid antibodies, leading to blood clots. Clinicians should consider this for patients with unusual thrombotic events and prior infectious disease history.
Sousan Kolahi, Leyla Ghadakchi, Amirreza Jabbaripour Sarmadian, Hamideh Azimi, Mehdi Jafarpour, Amirreza Khalaji   +5 more
doaj   +1 more source

The Stiffness of Cardiac Fibroblast Substrates Exerts a Regulatory Influence on Collagen Metabolism via α2β1 Integrin, FAK and Src Kinases

Cells, 2021
Information about mechanical strain in the extracellular space is conducted along collagen fibers connected with integrins and then transmitted within cells.
Małgorzata Gałdyszyńska, Paulina Radwańska, Jacek Szymański, Jacek Drobnik   +3 more
doaj   +1 more source

Immunoregulatory mechanisms of the arachidonic acid pathway in cancer

FEBS Letters, Volume 599, Issue 7, Page 927-951, April 2025.
The central role of the arachidonic acid (AA) pathway in anticancer immunity. Enzymes and metabolites of the AA pathway can play both immunosuppressive and immunostimulatory roles in the tumor microenvironment. Therefore, their tailored targeting could be beneficial as a standalone therapy or in combination with current cancer immunotherapy.
Maria Tredicine, Matteo Mucci, Antonio Recchiuti, Domenico Mattoscio   +3 more
wiley   +1 more source

Perturbations in fatty acid metabolism and collagen production infer pathogenicity of a novel MBTPS2 variant in Osteogenesis imperfecta

Frontiers in Endocrinology, 2023
Osteogenesis imperfecta (OI) is a heritable and chronically debilitating skeletal dysplasia. Patients with OI typically present with reduced bone mass, tendency for recurrent fractures, short stature and bowing deformities of the long bones.
Pei Jin Lim, Giulio Marcionelli, Pakeerathan Srikanthan, Timothée Ndarugendamwo, Jason Pinner, Jason Pinner, Marianne Rohrbach, Cecilia Giunta   +7 more
doaj   +1 more source

The role of topology and mechanics in uniaxially growing cell networks [PDF]

, 2019
In biological systems, the growth of cells, tissues, and organs is influenced by mechanical cues. Locally, cell growth leads to a mechanically heterogeneous environment as cells pull and push their neighbors in a cell network. Despite this local heterogeneity, at the tissue level, the cell network is remarkably robust, as it is not easily perturbed by ...
arxiv   +1 more source

Pathological and histopatnotogical studies of the swimbladder of eels Anguilla anguitla infected by Angutlticpta crassus (Nemafoda: Dracuncuioidea) [PDF]

, 1993
The swimbladder lesions produced by Anguillicola crassus (Nematoda) infection, causing mass mortality among eels in Lake Balaton (Hungary) were studied by histological methods.
Baska, Ferenc, Csaba, G., Glávits, Róbert, Molnár, Kálmán, Székely, Csaba   +4 more
core   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source