Results 21 to 30 of about 23,656 (209)
Expression of connexin-43 in surgical resections of primary tumor and lymph node metastases of squamous cell carcinoma and adenocarcinoma of the lung: a retrospective study [PDF]
PeerJ, 2022 Background Connexins are transmembrane proteins forming gap junctions between the cells, which allow intercellular communication. Significance of gap junctions and connexins in lung carcinoma is not yet understood.
Ivana Savic +4 more
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Connexin 43 confers chemoresistance through activating PI3K
Oncogenesis, 2022 Circumventing chemoresistance is crucial for effectively treating cancer including glioblastoma, a lethal brain cancer. The gap junction protein connexin 43 (Cx43) renders glioblastoma resistant to chemotherapy; however, targeting Cx43 is difficult ...
Kevin J. Pridham +16 more
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Folia Histochemica et Cytobiologica, 2008 The interaction of connexin 43 and E-cadherin may play an important role in carcinogenesis and malignant behaviour of tumours. In this study, we examined the relationship between connexin 43 and E-cadherin in human non-small cell lung cancers (NSCLC ...
En-Hua Wang +6 more
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Internal translation of the connexin 43 transcript [PDF]
Cell Communication and Signaling, 2014 Connexin 43 (Cx43), the most widely expressed gap junction protein, is associated with a number of physiological and pathological conditions. Many functions of Cx43 have been shown to be independent of gap junction formation and only require the expression of Cx43 C-terminal fragments.
Salat-Canela, Clàudia +4 more
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Connexin43 and Ischemic Preconditioning [PDF]
Cardiovascular Research, 2004 Connexin43 (Cx43) is the essential protein to form hemichannels and gap junctions in the myocardium. The phosphorylation status of Cx43 which is regulated by a variety of protein kinases and phosphatases determines hemichannel and/or gap junction conductance and permeability.
Rainer, Schulz, Gerd, Heusch
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Connexin-43-dependent ATP release mediates macrophage activation during sepsis
eLife, 2019 Bacterial spillage into a sterile environment following intestinal hollow-organ perforation leads to peritonitis and fulminant sepsis. Outcome of sepsis critically depends on macrophage activation by extracellular ATP-release and associated autocrine ...
Michel Dosch +7 more
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Connexin 43 Hemichannels Regulate Osteoblast to Osteocyte Differentiation
Frontiers in Cell and Developmental Biology, 2022 Connexin 43 (Cx43) is the predominant connexin subtype expressed in osteocytes. Osteocytes, accounting for 90%–95% of total bone cells, function as orchestrators coordinating balanced activity between bone-resorbing osteoclasts and bone-forming ...
Rui Hua, Sumin Gu, Jean X. Jiang
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The Importance of Connexin 43 in Enamel Development and Mineralization [PDF]
Frontiers in Physiology, 2018 During enamel development, formation of hydroxyapatite crystals and regulation of pH in the enamel matrix require massive transport of ions. Both ameloblasts and adjacent dental epithelial cells in the stellate reticulum co-express several transmembrane cotransporters/ion-exchangers for transport of ions across plasma membranes.
Sali Al-Ansari +12 more
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BMC Medicine, 2008 Background The modulation of gap junctional communication between tumor cells and between tumor and vascular endothelial cells during tumorigenesis and metastasis is complex.
Gillespie Mark N +5 more
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Connexin 43: An Interface Connecting Neuroinflammation to Depression
Molecules, 2023 Major depressive disorder (MDD) is a leading chronic mental illness worldwide, characterized by anhedonia, pessimism and even suicidal thoughts. Connexin 43 (Cx43), mainly distributed in astrocytes of the brain, is by far the most widely and ubiquitously
Hong Jiang +3 more
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