Results 41 to 50 of about 23,656 (209)

Osteoinductivity of calcium phosphate mediated by connexin 43 [PDF]

Biomaterials, 2013
Recent reports have alluded to the osteoinductive properties of calcium phosphate, yet the cellular processes behind this are not well understood. To gain insight into the molecular mechanisms of this phenomenon, we have conducted a series of in vitro and in vivo experiments using a scaffoldless three dimensional (3D) dental pulp cell (DPC) construct ...
Fatima N, Syed-Picard, Thottala, Jayaraman, Raymond S K, Lam, Elia, Beniash, Charles, Sfeir   +4 more
openaire   +2 more sources

Connexin Expression in Human Minor Salivary Glands: An Immunohistochemical Microscopy Study

Molecules, 2022
Connexins (Cxs) are transmembrane proteins involved in the formation of hemichannels and gap junctions (GJs). GJs are involved in various physiological functions, including secretion in glandular tissue. It has been demonstrated that Cx26, Cx32, and Cx43
Alessandra Falleni, Stefania Moscato, Giovanni Fulvio, Enza Polizzi, Margherita Bernardeschi, Francesco Bianchi, Valentina Donati, Manuela Cabiati, Chiara Ippolito, Silvia Del Ry, Chiara Baldini, Letizia Mattii   +11 more
doaj   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

A Central Role of Connexin 43 in Hypoxic Preconditioning [PDF]

The Journal of Neuroscience, 2008
Preconditioning is an endogenous mechanism in which a nonlethal exposure increases cellular resistance to subsequent additional severe injury. Here we show that connexin 43 (Cx43) plays a key role in protection afforded by preconditioning. Cx43 null mice were insensitive to hypoxic preconditioning, whereas wild-type littermate mice exhibited a ...
Jane H-C, Lin, Nanhong, Lou, Ning, Kang, Takahiro, Takano, Furong, Hu, Xiaoning, Han, Qiwu, Xu, Ditte, Lovatt, Arnulfo, Torres, Klaus, Willecke, Jay, Yang, Jian, Kang, Maiken, Nedergaard   +12 more
openaire   +2 more sources

Bioprinting High‐Cell‐Density Cardiac Tissue Constructs With Sustained Contractile Function

Advanced Healthcare Materials, EarlyView.
Contractile cardiomyocytes in 3D culture provide insights into the behavior of the heart. Combining a 3D bioprinting approach with a multi‐electrode array allows the development of the 3D culture to be monitored over time, and matured cultures allow the effect of drugs on cardiac function to be modelled, replicating effects seen in clinical application.
Priscila Melo, Wing Tai Tung, Harvey Lewis, Kavin Hettiarachchilage, Babis Tzivelekis, Rolando Berlinguer‐Palmini, Ana Marina Ferreira, Jason Gill, Kenneth Dalgarno   +8 more
wiley   +1 more source

Patient‐Derived 3D Heart‐On‐a‐Chip Model of Dilated Cardiomyopathy With Embedded Bead‐Based Mapping of Tissue Contractility

Advanced Healthcare Materials, EarlyView.
A heart‐on‐a‐chip model of dilated cardiomyopathy is developed from patient‐derived induced pluripotent stem cells. The model recapitulates key disease phenotypes and enables functional assessment through integrated bead‐based tracking and pillar deflection measurements.
Ali Mousavi, Ludovic Mouttet, Shihao Cui, Yasaman Hekmatnia, Mehran Mottahedi, Ida Derish, Naimeh Rafatian, Mark Aurousseau, Gregor Andelfinger, Renzo Cecere, Houman Savoji   +10 more
wiley   +1 more source

Recent Advances in Ferrite‐Based Materials for Biomedical Applications: A Comprehensive Review

Advanced Materials, EarlyView.
Ferrite nanoplatforms are presented as tunable biomedical materials in which synthesis control, cation engineering, defect/morphology regulation, and surface functionalization govern structure–property–bioactivity relationships. These design strategies enable multifunctional applications including MRI contrast, magnetic hyperthermia, targeted drug ...
Pramod D. Mhase, Varsha C. Pujari, Akash V. Fulari, Sunil M. Patange, Sean Li, Danyang Wang, Sagar E. Shirsath   +6 more
wiley   +1 more source

Connexin 43 contributes to ectopic orofacial pain following inferior alveolar nerve injury

Molecular Pain, 2016
Background Clinically, it is well known that injury of mandibular nerve fiber induces persistent ectopic pain which can spread to a wide area of the orofacial region innervated by the uninjured trigeminal nerve branches.
Kaori Kaji DDS, Masamichi Shinoda DDS, PhD, Kuniya Honda DDS, PhD, Syumpei Unno PhD, Noriyoshi Shimizu DDS, PhD, Koichi Iwata DDS, PhD   +5 more
doaj   +1 more source

Engineering Pluripotent Stem Cells‐Derived Inner Ear Organoids With Enhanced Maturation and Reproducibility by Micro‐Topographical Cues

Advanced Materials, EarlyView.
Micro‐topographical cues applied through temporally controlled microscale confinement improve the reproducibility, spatial organization, and neurosensory‐associated features of pluripotent stem cell‐derived inner ear organoids. Integration with a vascularized organoid platform further enables controlled investigation of vascular‐epithelial interactions
Harshita Sharma, Jungeun Lim, Woochan Kim, Yeon Ju Kim, Dream Kim, Shinyull Lee, Chaeyeon Park, Stephen Rhee, Shruthy Kuttapan, Jungho Ha, Sang Wook Park, Kyunghoon Kim, Noo Li Jeon, Sunho Park, Yun‐Hoon Choung, Jangho Kim   +15 more
wiley   +1 more source

Polymorphism in the C-terminal Cytoplasmic Site, Arginine Phosphorylation Site and 3′UTR of Connexin 43 and its Association with the Progression of Disc Herniation

Global Spine Journal, 2016
Introduction Intervertebral disc being an avascular tissue, the gap junction protein connexin play an important role in nutrient and extracellular matrix protein play a major role in its structural stability. The pathophysiology underlying the process of
Kavitha Rajsekar, Meenakshi Kuhar, Nandita Narayanasamy, Sandeep Vaishya, Niranjali Devaraj, Rajasekaran Shanmuganathan   +5 more
doaj   +1 more source