Results 31 to 40 of about 23,656 (209)
Gating and regulation of connexin 43 (Cx43) hemichannels [PDF]
Proceedings of the National Academy of Sciences, 2003 Connexin 43 (Cx43) nonjunctional or “unapposed” hemichannels can open under physiological or pathological conditions. We characterize hemichannels comprised of Cx43 or Cx43-EGFP (Cx43 with enhanced GFP fused to the C terminus) expressed in HeLa cells. Channel opening was induced at potentials greater than +60 mV.
Contreras, JE +3 more
openaire +5 more sources
Journal of Experimental & Clinical Cancer Research, 2010 Background bFGF is an important growth factor for glioma cell proliferation and invasion, while connexin 43 is implicated in the suppression of glioma growth.
Liu Hongsheng +5 more
doaj +1 more source
Cellular Physiology and Biochemistry, 2016 Aims: Connexin 43 is one of the most potent gap junction proteins related to osteoblast differentiation and bone formation. We hypothesized that Connexin 43 is a significant factor in osteogenic differentiation in the posterior longitudinal ligament ...
Haisong Yang +6 more
doaj +1 more source
IMMUNOHISTOCHEMICAL LOCALIZATION OF CONNEXIN 43 IN THE CORNEA OF THE ONE HUMPED CAMEL (CAMELUS DROMEDARIES) [PDF]
Assiut Veterinary Medical Journal, 2015 The present study has described for the first time the expression of connexin 43 in the cornea of camel. The camel cornea was composed of five layers, the corneal epithelium, subepithelial basement membrane (Bowman’s membrane), substantiapropria or ...
ENAS A.A. ELHAFEZ, KHALED ALY
doaj +1 more source
BMC Cardiovascular Disorders, 2006 Background Organ transplantation is presently often the only available option to repair a damaged heart. As heart donors are scarce, engineering of cardiac grafts from autologous skeletal myoblasts is a promising novel therapeutic strategy.
Kienast Yvonne +9 more
doaj +1 more source
Identification of the Calmodulin Binding Domain of Connexin 43 [PDF]
Journal of Biological Chemistry, 2007 Calmodulin (CaM) has been implicated in mediating the Ca(2+)-dependent regulation of gap junctions. This report identifies a CaM-binding motif comprising residues 136-158 in the intracellular loop of Cx43. A 23-mer peptide encompassing this CaM-binding motif was shown to bind Ca(2+)-CaM with 1:1 stoichiometry by using various biophysical approaches ...
Yubin, Zhou +8 more
openaire +2 more sources
Reproductive Biology and Endocrinology, 2006 Background Prolonged labour is associated with greater morbidity and mortality for mother and child. Connexin 43 is a major myometrial gap junction protein found in human myometrium.
Malmström Anders +6 more
doaj +1 more source
Reproductive Biology and Endocrinology, 2008 Background Myometrial smooth myocytes contract as a result of electrical signalling via a process called excitation-contraction coupling. This process is understood in great detail at the cellular level but the generation and coordination of electrical ...
Van Lommel Alfons +6 more
doaj +1 more source
Connexin 43: Key roles in the skin
Biomedical Reports, 2017 Gap junctions are tightly packed intercellular channels that serve a common purpose of allowing the intercellular exchange of small metabolites, second messengers and electrical signals. Connexins (Cxs) are gap junction proteins. Currently, 20 and 21 members of Cxs have been characterized in mice and humans, respectively. Connexin 43 (Cx43) is the most
Xiao-Fei, Zhang, Xiaofeng, Cui
openaire +3 more sources
Advanced Functional Materials, EarlyView.A 3D anisotropic hydrogel derived from heart extracellular matrix guides cytoskeletal alignment and nuclear remodeling in reprogrammed cardiomyocyte‐like cells. This study reveals how matrix alignment modulates nuclear envelope dynamics and chromatin state, triggering transcriptional and functional maturation.
Seung Ju Seo +7 more
wiley +1 more source