Results 111 to 120 of about 64,299 (311)
Journal of Cardiovascular Electrophysiology, EarlyView.ABSTRACT Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia encountered in clinical practice. Its incidence increases significantly with age and has become a major global public health issue. Although research into the mechanisms of AF has spanned over a century‐ranging from the reentry theory to the rotor hypothesis‐none of these
Xin Chu +4 more
wiley +1 more source
Hemichannels in neurodegenerative diseases: is there a link to pathology?
Frontiers in Cellular Neuroscience, 2014 Although originally considered a structural component of gap junctions, connexin hemichannels (HCs) are now recognized as functional entities capable of influencing metabolic gradients within the CNS, allowing direct communication between the intra- and ...
Megan eBosch, Tammy eKielian
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Annals of the New York Academy of Sciences, EarlyView.Myocardial sleeves of the pulmonary veins in racehorses with paroxysmal atrial fibrillation exhibit upregulated pathways associated with tissue structure remodeling. Pathways related to the extracellular matrix and cellular components differ significantly from those in healthy horses.
Magdalena Arevalo‐Turrubiarte +8 more
wiley +1 more source
Biochemical and immunochemical analysis of the arrangement of connexin43 in rat heart gap junction membranes [PDF]
, 1990 A 43 × 10^3 M_r protein (designated connexin43 or Cx43) is a major constituent of heart gap junctions. The understanding of its arrangement in junctional membranes has been extended by means of site-directed antibodies raised against synthetic peptides ...
Laird, D. W., Revel, J.-P.
core
Multiple Epidermal Connexins are Expressed in Different Keratinocyte Subpopulations Including Connexin 31 [PDF]
, 2001 Wei‐Li Di +3 more
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Spaceborne and spaceborn: Physiological aspects of pregnancy and birth during interplanetary flight
Experimental Physiology, EarlyView.Abstract Crewed interplanetary return missions that are on the planning horizon will take years, more than enough time for initiation and completion of a pregnancy. Pregnancy is viewed as a sequence of processes – fertilization, blastocyst formation, implantation, gastrulation, placentation, organogenesis, gross morphogenesis, birth and neonatal ...
Arun V. Holden
wiley +1 more source
Computational study of the excitation of human induced pluripotent stem cell‐derived cardiomyocytes
Experimental Physiology, EarlyView.Abstract Human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CMs) have proven to be a revolutionary advance for tissue engineering, disease modelling, and drug testing and discovery. Computational modelling enables detailed electrophysiological analysis that is otherwise difficult or impossible to achieve under strictly experimental ...
Roshni Shetty +2 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2019 Connexins (Cxs) are ubiquitous membrane proteins that are found throughout vertebrate organs, acting as building blocks of the gap junctions (GJs) known to play vital roles in the normal function of many organs.
Xuewen Wu +4 more
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CO2-Sensitive Connexin Hemichannels in Neurons and Glia: Three Different Modes of Signalling? [PDF]
, 2021 Emily Hill, Nicholas Dale, Mark J. Wall
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