Results 161 to 170 of about 75,295 (332)
Structure and permeability of ion-channels by integrated AFM and waveguide TIRF microscopy. [PDF]
, 2014 Membrane ion channels regulate key cellular functions and their activity is dependent on their 3D structure. Atomic force microscopy (AFM) images 3D structure of membrane channels placed on a solid substrate.
Arce, Fernando Teran +5 more
core +2 more sources
Connexins in the Central Nervous System: Physiological Traits and Neuroprotective Targets
Frontiers in Physiology, 2017 Cell-to-cell interaction and cell-to-extracellular environment communication are emerging as new therapeutic targets in neurodegenerative disorders. Dynamic expression of connexins leads to distinctive hemichannels and gap junctions, characterized by ...
Nunzio Vicario +7 more
doaj +1 more source
The proposed plant connexin is a protein kinase-like protein. [PDF]
, 1993 Arcady Mushegian, Eugene V. Koonin
openalex +1 more source
The human colon: Evidence for degenerative changes during aging and the physiological consequences
Neurogastroenterology &Motility, EarlyView.Reduced nociceptor innervation can explain diminished abdominal pain among the elderly. Degenerative changes occur within the colon wall, especially ascending colon. Mechanisms may include senescence‐like activity and inflammaging. Constipation is more likely to occur during age‐related challenges affecting functions of the bowel that now have reduced ...
Nicholas Baidoo, Gareth J. Sanger
wiley +1 more source
Intercellular Calcium Signaling in Astrocytes via ATP Release through Connexin Hemichannels*
Journal of Biological Chemistry, 2002 Astrocytes are capable of widespread intercellular communication via propagated increases in intracellular Ca2+ concentration. We have used patch clamp, dye flux, ATP assay, and Ca2+ imaging techniques to show that one mechanism for this intercellular ...
Charles E Stout +3 more
semanticscholar +1 more source
Relevance of Gap Junctions and Large Pore Channels in Traumatic Brain Injury
Frontiers in Physiology, 2014 In case of traumatic brain injury (TBI), occurrence of central nervous tissue damage is frequently aligned with local modulations of neuronal and glial gap junction channel expression levels.
Nora eProchnow
doaj +1 more source
Mechanisms of enteric neuropathy in diverse contexts of gastrointestinal dysfunction
Neurogastroenterology &Motility, EarlyView.Abstract The enteric nervous system (ENS) commands moment‐to‐moment gut functions through integrative neurocircuitry housed in the gut wall. The functional continuity of ENS networks is disrupted in enteric neuropathies and contributes to major disturbances in normal gut activities including abnormal gut motility, secretions, pain, immune dysregulation,
Julia R. Jamka, Brian D. Gulbransen
wiley +1 more source
Mind the Gaps in Tumor Immunity: Impact of Connexin-Mediated Intercellular Connections
Frontiers in Immunology, 2017 Gap junctions (GJs)-mediated intercellular communications (GJICs) are connexin (Cx)-formed plasma membrane channels that allow for the passage of small molecules between adjacent cells, and are involved in several physiopathological processes, including ...
María Alejandra Gleisner +9 more
doaj +1 more source
The role of reactive enteric glia‐macrophage interactions in acute and chronic inflammation
Neurogastroenterology &Motility, EarlyView.Abstract Enteric glia are a heterogeneous population of peripheral glia within the enteric nervous system and play pivotal roles in gut homeostasis, tissue integrity, coordination of motility, and intestinal immune responses. Under physiological conditions, they communicate with enteric neurons to control intestinal motility.
Schneider Reiner +4 more
wiley +1 more source
Neurogastroenterology &Motility, EarlyView.In vitro studies with GI surgical specimens or biopsy are a critical step in translating preclinical studies in animals to humans before testing potential therapeutic interventions in expensive clinical trials. Routine availability of human gut specimens, in combination with technological advances and powerful new in vitro models of the human ENS from ...
Dmitrii Pavlov, Fievos L. Christofi
wiley +1 more source