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Connexin Channels, Connexin Mimetic Peptides and ATP Release [PDF]
Cell Communication and Adhesion, 2003 Connexin hemichannels, that is, half gap junction channels (not connecting cells), have been implicated in the release of various messengers such as ATP and glutamate. We used connexin mimetic peptides, which are, small peptides mimicking a sequence on the connexin subunit, to investigate hemichannel functioning in endothelial cell lines.
Luc Leybaert +2 more
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Biology of the Cell, 2002
Summry— Connexin channels clustered at gap junctions are obligatory attributes of all macroscopic endocrine and exocrine glands investigated so far and also connect most types of cells which produce secretory products in other tissues. Increasing evidence indicates that connexins, and the cell‐to‐cell communications that these proteins permit ...
Serre Beinier, Véronique +8 more
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Summry— Connexin channels clustered at gap junctions are obligatory attributes of all macroscopic endocrine and exocrine glands investigated so far and also connect most types of cells which produce secretory products in other tissues. Increasing evidence indicates that connexins, and the cell‐to‐cell communications that these proteins permit ...
Serre Beinier, Véronique +8 more
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Cell and Tissue Research, 2014
Connexins are essential in the propagation of electrical activity throughout the heart and are an important determinant of conduction velocity. Their dysfunction is an important factor in the genesis of abnormal cardiac rhythm and is relevant to the pathogenesis of a wide variety of cardiac pathologies. Here, we review the basic biology of connexins in
Pier D, Lambiase, Andrew, Tinker
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Connexins are essential in the propagation of electrical activity throughout the heart and are an important determinant of conduction velocity. Their dysfunction is an important factor in the genesis of abnormal cardiac rhythm and is relevant to the pathogenesis of a wide variety of cardiac pathologies. Here, we review the basic biology of connexins in
Pier D, Lambiase, Andrew, Tinker
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Connexins are mechanosensitive
American Journal of Physiology-Cell Physiology, 2004Connexins form gap junction channels that provide a hydrophilic path between cell interiors. Some connexins, particularly the lens connexins, Cx46 and Cx50 and their orthologs, can form functional hemichannels in nonjunctional membranes. These hemichannels are a nonselective conduit to the extracellular medium and may jeopardize cell survival.
Li, Bao, Frederick, Sachs, Gerhard, Dahl
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Biology of the Cell, 2002
Summry— The hypothesis, that gap junctional intercellular communication plays a key role in carcinogenesis and more generally in growth control was formulated nearly 40 years ago. From this time, data accumulated, showing that this type of communication is frequently decreased or absent in cells treated with tumor promoting agents, among transformed ...
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Summry— The hypothesis, that gap junctional intercellular communication plays a key role in carcinogenesis and more generally in growth control was formulated nearly 40 years ago. From this time, data accumulated, showing that this type of communication is frequently decreased or absent in cells treated with tumor promoting agents, among transformed ...
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Trends in Cardiovascular Medicine, 1992
Gap junctions are specialized regions of adjoining cell membranes composed of numerous intercellular low-resistance channels. In the heart, these channels electrotonically couple adjacent myocytes and synchronize the cardiac action potential. Signaling through gap junction channels may also influence embryogenesis and development.
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Gap junctions are specialized regions of adjoining cell membranes composed of numerous intercellular low-resistance channels. In the heart, these channels electrotonically couple adjacent myocytes and synchronize the cardiac action potential. Signaling through gap junction channels may also influence embryogenesis and development.
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2006
Remodeling of the vascular wall plays a central role in many physiological processes, but also in the pathogenesis of cardiovascular diseases such as atherosclerosis and restenosis. Atherosclerosis represents the major cause of death and disability in adult populations of Western societies.
Chadjichristos, Christos +2 more
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Remodeling of the vascular wall plays a central role in many physiological processes, but also in the pathogenesis of cardiovascular diseases such as atherosclerosis and restenosis. Atherosclerosis represents the major cause of death and disability in adult populations of Western societies.
Chadjichristos, Christos +2 more
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Connexins and Cardiac Arrhythmias
2006During cardiac remodeling, impulse conduction in the heart is altered by changes in excitability, electrical coupling, and tissue architecture. The impairment of normal impulse conduction is one of the factors that increases the propensity for arrhythmias. This chapter focuses on the relationship between electrical coupling between ventricular myocytes
van Rijen, Harold V. M. +4 more
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