Results 151 to 160 of about 56,231 (274)
Advanced Healthcare Materials, Volume 15, Issue 15, 17 April 2026.Zinc‐containing bioactive glass (ZnBG) promotes diabetic wound healing by regulating macrophage extracellular traps (METs). Specifically, ZnBG reduces oxidative stress and inhibits the PAD4 and NLRP3/caspase‐1/GSDMD signaling pathways, thereby suppressing MET formation.
RuiYang Sun +11 more
wiley +1 more source
Advanced Sensor Research, Volume 5, Issue 4, April 2026.Sensorineural hearing loss (SNHL) occurs in 1.5 billion globally, primary driven by damage of cochlear hair cells and spiral ganglion neurons. This review systematically examines current therapeutic strategies for sensorineural hearing loss, including traditional drug and physical therapies as well as emerging stem cell and gene therapies, providing a ...
Ruirui Chen +3 more
wiley +1 more source
Connexins are tetraspan transmembrane proteins that form gap junctions and facilitate direct intercellular communication, a critical feature for the development, function, and homeostasis of tissues and organs. In addition, a growing number of gap junction-independent functions are being ascribed to these proteins.
Aasen, Trond|| +4 more
openaire +1 more source
Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism
Advanced Science, Volume 13, Issue 19, 2 April 2026.The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying +8 more
wiley +1 more source
Gap Junction-Mediated Communication in Melanoma: From Tumor Progression to Treatment Response. [PDF]
Int J Mol SciMassoud J +6 more
europepmc +1 more source
Brain and Behavior, Volume 16, Issue 4, April 2026.We find that loss of LRP1 in astrocytes improves long‐term outcomes after ischemic stroke and is associated with reduced gliosis. Our findings suggest a role for LRP1 in astrocyte reactivity and response to stroke. ABSTRACT Purpose Ischemic stroke is a primary cause of death and disability worldwide; however, therapeutic opportunities are limited ...
Meng Wang +4 more
wiley +1 more source
Hypoxia Increases Connexin46 and Connexin43 Levels in KNS-42 Glioblastoma Cells. [PDF]
Int J Mol SciMinogue PJ, Beyer EC, Berthoud VM.
europepmc +1 more source
Pathological Roles of Astrocytes in Traumatic Brain Injury
CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.TBI induces intrinsic astrocytic changes, including reactive astrogliosis, A1 and A2 polarization, ion channels activation, pathological edema, oxidative stress, and metabolic dysregulation. These injury‐responsive astrocytes regulate neuroinflammation and tissue remodeling through dynamic crosstalk with microglia, macrophages, vascular endothelial ...
Di Wu +7 more
wiley +1 more source
When the gatekeeper falls: developmental vulnerability of the thalamic reticular nucleus in neonatal and pediatric hypoxic-ischemic brain injury. [PDF]
Front Syst NeurosciHsiao K.
europepmc +1 more source
Current Protocols, Volume 6, Issue 4, April 2026.Abstract Immunocytochemistry (ICC) and immunohistochemistry (IHC) are related but separate techniques used for cell and tissue characterization. ICC involves immunolabeling of cells, and IHC immunolabeling of tissues; thus, the main difference is sample thickness. However, the distinction between ICC and IHC is not always clear and can be confusing. We
Aidyn M. Medina‐López +3 more
wiley +1 more source