Experimental and Molecular Medicine, 2020 Hearing loss: Disruption at the junction A decrease in the levels of connexin proteins at the junctions connecting cells in the inner-ear precedes age-related hearing loss (ARHL) in mice.
Shori Tajima +3 more
doaj +1 more source
Air-stimulated ATP release from keratinocytes occurs through connexin hemichannels. [PDF]
PLoS ONE, 2013 Cutaneous ATP release plays an important role in both epidermal stratification and chronic pain, but little is known about ATP release mechanisms in keratinocytes that comprise the epidermis.
Travis P Barr +5 more
doaj +1 more source
Levels and Modifications of Both Lens Fiber Cell Connexins Are Affected in Connexin Mutant Mice
Cells, 2022 In the lens, cell homeostasis and transparency are supported by intercellular communication facilitated by the channels formed of connexin46 (Cx46) and connexin50 (Cx50). Mutations of these connexins are linked to inherited cataracts.
Oscar Jara +3 more
doaj +1 more source
Acidosis potentiates endothelium-dependent vasorelaxation and gap junction communication in the superior mesenteric artery. [PDF]
, 2018 Extracellular pH is an important physiological determinant of vascular tone that is normally maintained within 7.35-7.45. Any change outside this range leads to severe pathological repercussions.
Mohanty, Ipsita +3 more
core +2 more sources
BMC Cell Biology, 2017 The lens is an avascular organ composed of an anterior epithelial cell layer and fiber cells that form the bulk of the organ. The lens expresses connexin43 (Cx43), connexin46 (Cx46) and connexin50 (Cx50). Epithelial Cx50 has critical roles in cell proliferation and differentiation, likely involving growth factor-dependent signaling pathways.
Viviana M. Berthoud, Anaclet Ngezahayo
openaire +3 more sources
Single and fractionated ionizing radiation induce alterations in endothelial connexin expression and channel function [PDF]
, 2019 Radiotherapy is an effective treatment for most tumor types. However, emerging evidence indicates an increased risk for atherosclerosis after ionizing radiation exposure, initiated by endothelial cell dysfunction. Interestingly, endothelial cells express
Aerts, An +8 more
core +2 more sources
A novel role for connexin hemichannel in oxidative stress and smoking-induced cell injury. [PDF]
PLoS ONE, 2007 Oxidative stress is linked to many pathological conditions, including ischemia, atherosclerosis and neurodegenerative disorders. The molecular mechanisms of oxidative stress induced pathophysiology and cell death are currently poorly understood.
Srinivasan Ramachandran +4 more
doaj +1 more source
Connexin Channels, Connexin Mimetic Peptides and ATP Release [PDF]
Cell Communication & Adhesion, 2003 Connexin hemichannels, that is, half gap junction channels (not connecting cells), have been implicated in the release of various messengers such as ATP and glutamate. We used connexin mimetic peptides, which are, small peptides mimicking a sequence on the connexin subunit, to investigate hemichannel functioning in endothelial cell lines.
Leybaert, L. +5 more
openaire +4 more sources
Adjuvant therapeutic potential of tonabersat in the standard treatment of glioblastoma : a preclinical F98 glioblastoma rat model study [PDF]
, 2019 Purpose Even with an optimal treatment protocol, the median survival of glioblastoma (GB) patients is only 12-15 months. Hence, there is need for novel effective therapies that improve survival outcomes.
Bonte, Ellen +11 more
core +1 more source
Protein–Protein Interactions with Connexin 43: Regulation and Function
International Journal of Molecular Sciences, 2018 Connexins are integral membrane building blocks that form gap junctions, enabling direct cytoplasmic exchange of ions and low-molecular-mass metabolites between adjacent cells.
P. Sorgen +4 more
semanticscholar +1 more source