Results 81 to 90 of about 75,295 (332)

Connexin 30 controls astroglial polarization during postnatal brain development

Development, 2018
Astrocytes undergo intense morphological maturation during development, changing from individual sparsely branched cells to polarized and tremendously ramified cells.
G. Ghézali, C. Calvo, Laure-Elise Pillet, Flora Llense, P. Ezan, U. Pannasch, A. Bemelmans, Sandrine Etienne Manneville, N. Rouach   +8 more
semanticscholar   +1 more source

The sleep-inducing lipid oleamide deconvolutes gap junction communication and calcium wave transmission in glial cells. [PDF]

, 1997
Oleamide is a sleep-inducing lipid originally isolated from the cerebrospinal fluid of sleep-deprived cats. Oleamide was found to potently and selectively inactivate gap junction-mediated communication between rat glial cells.
Cao, Charles, Charles, Cornell-Bell, Cravatt, Cravatt, Davidson, Dewey, El-Fouly, Enkvist, Enomoto, Feller, Finkbeiner, Fluri, Frame, Guan, Guan, Hansen, Hassinger, Hirschi, Jalife, Kumar, Kumar, Mege, Miller, Musil, Musil, Nedergaard, Neyton, Osipchuk, Palmer, Parpura, Suter, Veenstra, Venance, Warner   +35 more
core   +2 more sources

Connexins in Cancer: Jekyll or Hyde?

Biomolecules, 2020
The expression, localization, and function of connexins, the protein subunits that comprise gap junctions, are often altered in cancer. In addition to cell–cell coupling through gap junction channels, connexins also form hemichannels that allow ...
Erin E. Mulkearns-Hubert, Ofer Reizes, Justin D. Lathia   +2 more
doaj   +1 more source

Role and Posttranslational Regulation of Cx46 Hemichannels and Gap Junction Channels in the Eye Lens

Frontiers in Physiology, 2022
Connexins are a family of proteins that can form two distinct types of channels: hemichannels and gap junction channels. Hemichannels are composed of six connexin subunits and when open allow for exchanges between the cytoplasm and the extracellular ...
Mauricio A. Retamal, Mauricio A. Retamal, Mauricio A. Retamal, Guillermo A. Altenberg   +3 more
doaj   +1 more source

Progress and Application of Multifunctional Hydrogel in Radioactive Skin Injury

Advanced Materials Interfaces, EarlyView.
This review examines healing challenges in radiation‐wound injuries, where ionizing radiation impairs immune and tissue repair processes. Hydrogels, with their biocompatibility, antimicrobial properties, and drug delivery capabilities, present a transformative solution. It compares hydrogel efficacy in radiation‐induced versus common wounds, highlights
Xinyue Cui, Jingyi Wang, Xinyi Xu, Xiqian Cao, Yingtang Zhou, Jiaming Guo   +5 more
wiley   +1 more source

Virally Mediated Connexin 26 Expression in Postnatal Scala Media Significantly and Transiently Preserves Hearing in Connexin 30 Null Mice

Frontiers in Cell and Developmental Biology, 2022
Non-sensory cells in the sensory epithelium of the cochlea are connected extensively by gap junctions. Functionally null mutations in GJB6 (encoding Cx30) cause hearing loss in humans. In this study, we injected AAV1-CB7-Gjb2 into the scala media between
Li Zhang, Li Zhang, Li Zhang, Wenwen Wang, Wenwen Wang, Wenwen Wang, Sun Myoung Kim, Sun Myoung Kim, Jianjun Wang, Jianjun Wang, Binfei Zhou, Binfei Zhou, Weijia Kong, James Zheng, James Zheng, Xi Lin, Xi Lin   +16 more
doaj   +1 more source

Advances in Microfluidic Cochlea‐On‐A‐Chip

Advanced Science, EarlyView.
This review systematically examines diverse cell sources for inner ear organoids and outlines stepwise induction protocols. Furthermore, it discusses current applications and prospective developments of cochlea‐on‐a‐chip technologies in areas such as deafness modeling, mechanistic studies, and drug evaluation, with particular focus on gene‐therapy drug
Tian Shen, Shanying Han, Weiwei He, Wen Yang, Xinghua Tang, Xiaolong Zhao, Xinghong Liu, Zhenhua Shao, Lin Cheng, Yu Zhao, Jiangang Fan   +10 more
wiley   +1 more source

Connexin 26 and Connexin 43 in Canine Mammary Carcinoma [PDF]

Veterinary Sciences, 2019
Incidence of canine mammary carcinoma is two times higher than the rate of human breast cancer. Mammary tumors are the most common type of cancer in intact female dogs and account for about half of all neoplasms in these dogs. Well-established models of breast cancer have shown that neoplastic cells often have a loss of intercellular communication ...
Savannah Luu, Cynthia Bell, Sarah Schneider, Thu Annelise Nguyen   +3 more
openaire   +3 more sources

Eph-ephrin Signaling Affects Eye Lens Fiber Cell Intracellular Voltage and Membrane Conductance

Frontiers in Physiology, 2021
The avascular eye lens generates its own microcirculation that is required for maintaining lifelong lens transparency. The microcirculation relies on sodium ion flux, an extensive network of gap junction (GJ) plaques between lens fiber cells and ...
Catherine Cheng, Junyuan Gao, Xiurong Sun, Richard T. Mathias   +3 more
doaj   +1 more source

Viral‐Mediated Connexin 26 Expression Combined with Dexamethasone Rescues Hearing in a Conditional Gjb2 Null Mice Model

Advanced Science, EarlyView.
AAV2.7m8 serotype combined with the gfaABC1D promoter targets infection of supporting cells (SCs). AAV2.7m8‐gfaABC1D‐Gjb2 administration to mice results in excessive immune responses. The combination of AAV2.7m8‐gfaABC1D‐Gjb2 with dexamethasone (DEX) shows a synergistic effect and enhances the gene therapy effect in a conditional Cx26 null mice model ...
Xiaohui Wang, Li Zhang, Sen Chen, Le Xie, Yue Qiu, Chenyang Kong, Ge Yin, Weijia Kong, Yu Sun   +8 more
wiley   +1 more source