Results 121 to 130 of about 42,495 (277)

Role of connexins and pannexins during ontogeny, regeneration, and pathologies of bone

BMC Cell Biology, 2016
Electron micrographs revealed the presence of gap junctions in osteoblastic cells over 40 years ago. These intercellular channels formed from connexins are present in bone forming osteoblasts, bone resorbing osteoclasts, and osteocytes (mature ...
L. Plotkin, D. Laird, J. Amédée
semanticscholar   +1 more source

High‐throughput screening identifies bazedoxifene as a potential therapeutic for dysferlin‐deficient limb girdle muscular dystrophy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Limb‐girdle muscular dystrophy R2 (LGMD R2) is a rare genetic disorder characterised by progressive weakness and wasting of proximal muscles. LGMD R2 is caused by the loss of function of dysferlin, a transmembrane protein crucial for plasma membrane repair in skeletal muscles.
Celine Bruge, Nathalie Bourg, Emilie Pellier, Johana Tournois, Jerome Polentes, Manon Benabides, Noella Grossi, Anne Bigot, Anthony Brureau, Isabelle Richard, Xavier Nissan   +10 more
wiley   +1 more source

Developmental signals in skin morphogenesis [PDF]

, 2004
Non peer reviewedFinal Accepted ...
Prowse, David M.
core   +1 more source

Nimodipine reduces microglial activation in vitro as evidenced by morphological phenotype, phagocytic activity and high‐throughput RNA sequencing

British Journal of Pharmacology, EarlyView.
Background and Purpose Nimodipine, an L‐type voltage‐gated calcium channel blocker, is an approved cerebral vasorelaxant. We hypothesized that nimodipine attenuates the pro‐inflammatory shift in microglial phenotypes. Here, we analysed the effects of nimodipine on morphological and functional microglial phenotypes as well as their transcriptomic ...
István Pesti, Valentin Varga, Erda Qorri, Rita Frank, Diana Kata, Krisztián Vinga, Péter Archibald Szarvas, Ákos Menyhárt, Károly Gulya, Ferenc Bari, Eszter Farkas   +10 more
wiley   +1 more source

Dexrazoxane protects against doxorubicin‐induced cardiotoxicity in susceptible human living myocardial slices: A proof‐of‐concept study

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The increasing number of cancer survivors has caused growing concern over chemotherapy‐induced cardiotoxicity. This study aimed to investigate a novel human model of cardiotoxicity and explore cardioprotection. Experimental Approach Living myocardial slices (LMS) were obtained from explanted end‐stage heart failure ...
Jort S. A. van der Geest, Ilse R. Kelters, Bauke Arends, Willem B. van Ham, Ernest Diez Benavente, Thirza A. Lapré, Petra van der Kraak, Pim van der Harst, Arco J. Teske, Andreas Dendorfer, M. Mostafa Mokhles, Pieter A. Doevendans, Teun P. de Boer, Linda W. van Laake, Joost P. G. Sluijter, Vasco Sampaio‐Pinto   +15 more
wiley   +1 more source

Remyelination in experimentally demyelinated connexin 32 KnockOut mice Remielinização em camundongos KnockOut para conexina 32 desmielinizados experimentalmente

Arquivos de Neuro-Psiquiatria, 2009
The aim of this study was to evaluate the role of connexin 32 (Cx 32) during remyelination of the peripheral nervous system, through a local injection of either 0,1% ethidium bromide solution or saline in the sciatic nerve of Cx 32 knockout mice ...
Adriano Tony Ramos, Paulo César Maiorka, Maria Lúcia Zaidan Dagli, Fernando Yutaka Moniwa Hosomi, Kalan Bastos Violin, Andréa Latorre, Aline de Marco Viott, Eduardo Kenji Masuda, Maria Elisa Trost, Tessie Beck Martins, Dominguita Lühers Graça   +10 more
doaj   +1 more source

Compartmentalized and signal-selective gap junctional coupling in the hearing cochlea [PDF]

, 2006
Gap junctional intercellular communication (GJIC) plays a major role in cochlear function. Recent evidence suggests that connexin 26 (Cx26) and Cx30 are the major constituent proteins of cochlear gap junction channels, possibly in a unique heteromeric ...
Forge, A, Jagger, DJ
core   +1 more source

Connexin43 Promotes the Invasion and Metastasis of Lung Squamous Cell Carcinoma via GJIC‐Dependent Ca2+/ERK Signaling Activation

Cancer Science, EarlyView.
Cx43 mediated GJIC‐dependent delivery of second messenger Ca2+ thus activating the ERK signaling pathway. Verapamil, effective effectively inhibits these pathways. ABSTRACT Lung squamous cell carcinoma (LUSC) is an extremely metastatic cancer with limited available treatment and poor outcomes.
Xiaocheng Mo, Jingchuan He, Xiaoju Shen, Changsheng Li, Xiaoxiang Mo, Kai Liang, Liangjun He, Tingting Li, Xiaoqin Pan, Sisi Cao, Naiquan Mao, Shangping Xing, Zhiquan Chen, Zhuo Luo, Jie Yang   +14 more
wiley   +1 more source

Gap junction modulation and its implications for heart function

Frontiers in Physiology, 2014
Gap junction communication mediated by connexins is critical for heart function. To gain insight into the causal relationship of molecular mechanisms of disease pathology, it is important to understand which mechanisms contribute to impairment of gap ...
Stefan eKurtenbach, Sarah eKurtenbach, Georg eZoidl   +2 more
doaj   +1 more source

Lens connexins α3Cx46 and α8Cx50 interact with zonula occludens protein-1 (ZO-1) [PDF]

, 2003
Connexin α1Cx43 has previously been shown to bind to the PDZ domain–containing protein ZO-1. The similarity of the carboxyl termini of this connexin and the lens fiber connexins α3Cx46 and α8Cx50 suggested that these connexins may also interact with ZO-1.
Baruch, Amos, Benedetti, E. Lucio, Dunia, Irene, Giepmans, Ben N.G., Kumar, Nalin M, Nielsen, Peter A, Shestopalov, Valery I   +6 more
core   +3 more sources