Results 121 to 130 of about 27,985 (262)

Novel Roles for the Ectoenzyme CD38 in the Maintenance of Transcriptional and Metabolic Homeostasis in Astrocytes

Glia, Volume 74, Issue 2, February 2026.
CD38 deficiency influences brain NAD/NAM metabolism. Global CD38 deficiency drives changes in astrocyte mitochondrial, metabolic, senescence, and neurodegenerative‐related genes. CD38 deficiency alters glial reactivity and astrocyte bioenergetics. ABSTRACT CD38 is an ectoenzyme that converts NAD+ to NAM to help maintain bioenergetic homeostasis.
S. Basak, A. M. Colafrancesco, R. D. Hernandez, X. Wei, L. J. McMeekin, D. Dang, M. Simmons, J. L. Browning, K. Noel, F. Zhou, F. E. Lund, J. S. Saad, S. G. Watsen, A. M. Pickrell, R. M. Cowell, M. L. Olsen   +15 more
wiley   +1 more source

Connexin‐43 remodelling and arrhythmias: hemichannels as key drivers of cardiac dysfunction [PDF]

Priscila Araújo, Manuel F. Muñoz, Jonathan Quan, Jorge E. Contreras   +3 more
openalex   +1 more source

Letter to the Editor Connexin and fibrosis related microRNAs in complex fractionated atrial electrograms [PDF]

, 2015
Hui Yang, Chenlu Wu, Yichao Xiao, Shenghua Zhou   +3 more
openalex   +1 more source

Astrocyte MCT1 Expression Does Not Contribute to the Axonal Degenerative Phenotype Observed With Ubiquitous MCT1 Depletion

Glia, Volume 74, Issue 2, February 2026.
Loss of astrocytic MCT1 does not cause late onset neurodegeneration. As ubiquitous MCT1 deletion causes axonal degeneration, oligodendrocytes and potentially other cells are more prominent drivers of MCT1‐mediated metabolic support of neurons. ABSTRACT We recently reported that the loss of oligodendrocyte metabolic support through the lactate and ...
Thomas Philips, Emily G. Thompson, Olivia Spead, Balaji G. Vijayakumar, Erica R. Kent, Sean J. Miller, Treasure Nwokeleme, Svetlana Vidensky, Mohamed Hassan Farah, Jeffrey D. Rothstein   +9 more
wiley   +1 more source

Connexin 43 reduces susceptibility to sympathetic atrial fibrillation

, 2018
Beibei Luo, Yifei Yan, Zhiyu Zeng, Zhang Zhengnan, Haide Liu, Hao Liu, Jinyi Li, Weiqiang Huang, Jiangtao Wu, Yan He   +9 more
openalex   +2 more sources

Connexin Expression and Cell Coupling Fail to Reverse thev-srcTransformed Growth Characteristics of a Cx43–/– Cell [PDF]

, 2004
Anjana Chandrasekhar, Mary Merritt, Se Jong Huh, Bruce J. Nicholson, Shoshanna N. Zucker   +4 more
openalex   +1 more source

Aberrant Molecular Myelin Architecture in Charcot–Marie–Tooth Disease Type 1A and Hereditary Neuropathy With Liability to Pressure Palsies

Glia, Volume 74, Issue 2, February 2026.
PMP22 copy number variation disrupts myelin architecture at SLIs and Nodes of Ranvier. Adherens junction and axoglial domain defects are often more severe in CMT1A than HNPP. Findings support PMP22 functioning as a structural organizer of myelin. ABSTRACT Charcot–Marie–Tooth Disease Type 1A (CMT1A) and Hereditary Neuropathy with Liability to Pressure ...
Kathryn R. Moss, Marvis A. Arowolo, Dave R. Gutierrez, Ahmet Höke   +3 more
wiley   +1 more source

Mechanisms of permselectivity of connexin hemichannels to small molecules. [PDF]

J Biol Chem
Lovatt A, Butler J, Dale N.
europepmc   +2 more sources

Apelin Ameliorates High Glucose-Induced Downregulation of Connexin 43 via AMPK-Dependent Pathway in Neonatal Rat Cardiomyocytes [PDF]

, 2018
Xiaoting Li, Lu Yu, Jing Gao, Xukun Bi, Juhong Zhang, Shiming Xu, Meihui Wang, Mengmeng Chen, Fuyu Qiu, Guosheng Fu   +9 more
openalex   +1 more source

Current Trends in Duchenne Muscular Dystrophy Research and Therapy: 3D Cardiac Modelling

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Duchenne muscular dystrophy (DMD), caused by dystrophin deficiency, presents a multifaceted challenge that affects both skeletal muscle function and cardiomyocyte homeostasis, causing progressive degeneration and life‐threatening cardiac complications by adolescence.
Marta Przymuszała, Marta Białobrzeska, Józef Dulak, Urszula Florczyk‐Soluch   +3 more
wiley   +1 more source