Results 131 to 140 of about 42,495 (277)

Revitalising Aging Oocytes: Echinacoside Restores Mitochondrial Function and Cellular Homeostasis Through Targeting GJA1/SIRT1 Pathway

open access: yesCell Proliferation, EarlyView.
ECH protects senescent oocytes by stabilising the cytoskeleton, restoring mitochondrial function, reducing oxidative stress and maintaining cellular homeostasis, primarily through the GJA1/SIRT1 signalling pathway. ABSTRACT As maternal age increases, the decline in oocyte quality emerges as a critical factor contributing to reduced reproductive ...
Liuqing Yang   +13 more
wiley   +1 more source

Beneficial and Detrimental Remodeling of Glial Connexin and Pannexin Functions in Rodent Models of Nervous System Diseases

open access: yesFrontiers in Cellular Neuroscience, 2019
A variety of glial cell functions are supported by connexin and pannexin proteins. These functions include the modulation of synaptic gain, the control of excitability through regulation of the ion and neurotransmitter composition of the extracellular ...
Lucila Brocardo   +3 more
doaj   +1 more source

Single and fractionated ionizing radiation induce alterations in endothelial connexin expression and channel function [PDF]

open access: yes, 2019
Radiotherapy is an effective treatment for most tumor types. However, emerging evidence indicates an increased risk for atherosclerosis after ionizing radiation exposure, initiated by endothelial cell dysfunction. Interestingly, endothelial cells express
Aerts, An   +8 more
core   +2 more sources

The cardio‐renal‐metabolic role of the nod‐like receptor protein‐3 and senescence‐associated secretory phenotype in early sodium/glucose cotransporter‐2 inhibitor therapy in people with diabetes who have had a myocardial infarction

open access: yesDiabetic Medicine, EarlyView.
Abstract Aims Following an acute myocardial infarction (AMI), individuals with type 2 diabetes (T2DM) have a 2‐to‐3 fold increased risk of mortality compared to those without diabetes, and globally cardiorenal complications account for 50% of diabetes‐related deaths.
M. U. Shah   +4 more
wiley   +1 more source

Connexins in the early development of the African clawed frog Xenopus laevis (Amphibia): The role of the connexin43 carboxyl terminal tail in the establishment of the dorso-ventral axis

open access: yesGenetics and Molecular Biology, 2007
Connexins are a family of related proteins identified in vertebrate forming gap junctions, which mediate cell-to-cell communication in early embryos, with an important role in establishing embryonic asymmetry and ‘communication compartments’.
Jaime Cofre, Eliana Abdelhay
doaj   +1 more source

Oncogenic processes [PDF]

open access: yes, 2014
No abstract ...
Nasir, L.   +3 more
core   +3 more sources

A metastasis‐associated pannexin‐1 mutant (Panx11‐89) forms a minimalist ATP release channel

open access: yesThe FEBS Journal, EarlyView.
A truncation mutant of Panx1 (Panx11‐89), enriched in metastatic breast cancer cells, is capable of forming a large ATP‐permeable membrane channel despite containing only 20% of the amino‐terminal amino acids of the wild‐type channel protein (wtPanx1). However, cells expressing Panx11‐89 alone die, whereas co‐expression of wtPanx1 is protective.
Junjie Wang   +5 more
wiley   +1 more source

Atrial Fibrillation (AF) and Heart Failure With Preserved Ejection Fraction (HFpEF): Advances and Challenges

open access: yesJournal of Cardiovascular Electrophysiology, EarlyView.
ABSTRACT This state‐of‐the‐art review is based on the Philippe Coumel Lecture in 2024 (Figure 1). It highlights the confluence of two major cardiovascular epidemics, atrial fibrillation and heart failure, with preserved ejection fraction. In these conditions, advances in electrophysiology and heart failure physiology are intertwined and are integrated ...
Sanjeev Saksena   +3 more
wiley   +1 more source

The human colon: Evidence for degenerative changes during aging and the physiological consequences

open access: yesNeurogastroenterology &Motility, EarlyView.
Reduced nociceptor innervation can explain diminished abdominal pain among the elderly. Degenerative changes occur within the colon wall, especially ascending colon. Mechanisms may include senescence‐like activity and inflammaging. Constipation is more likely to occur during age‐related challenges affecting functions of the bowel that now have reduced ...
Nicholas Baidoo, Gareth J. Sanger
wiley   +1 more source

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