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Molecular Configuration, Regulation and Function of Heterochannel Electrical Synapses
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The many ways astroglial connexins regulate neurotransmission and behavior
Glia, 2021Astrocytes have emerged as major players in the brain, contributing to many functions such as energy supply, neurotransmission, and behavior. They accomplish these functions in part via their capacity to form widespread intercellular networks and to ...
David Mazaud +2 more
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Connexins: Key Players in the Control of Vascular Plasticity and Function
Physiological Reviews, 2020Of the 21 members of the connexin family, 4 (Cx37, Cx40, Cx43, and Cx45) are expressed in the endothelium and/or smooth muscle of intact blood vessels to a variable and dynamically regulated degree.
U. Pohl
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Joint diseases: from connexins to gap junctions
Nature Reviews Rheumatology, 2017Henry J Donahue +2 more
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Plasma Membrane Channels Formed by Connexins: Their Regulation and Functions
Physiological Reviews, 2003Juan C Sáez, Eric C Beyer
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Biochimie, 2010
The role of gap junctions in proliferation, differentiation and apoptosis has been recently highlighted. Nevertheless, the molecular mechanisms that control these physiological events by acting on gap junction channels are still unknown. We have recently demonstrated that heteromeric gap junction plaques composed by Cx43 and Cx33 are unstable at the ...
Diane, Carette +3 more
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The role of gap junctions in proliferation, differentiation and apoptosis has been recently highlighted. Nevertheless, the molecular mechanisms that control these physiological events by acting on gap junction channels are still unknown. We have recently demonstrated that heteromeric gap junction plaques composed by Cx43 and Cx33 are unstable at the ...
Diane, Carette +3 more
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Connexins are mechanosensitive
American Journal of Physiology-Cell Physiology, 2004Connexins form gap junction channels that provide a hydrophilic path between cell interiors. Some connexins, particularly the lens connexins, Cx46 and Cx50 and their orthologs, can form functional hemichannels in nonjunctional membranes. These hemichannels are a nonselective conduit to the extracellular medium and may jeopardize cell survival.
Li, Bao, Frederick, Sachs, Gerhard, Dahl
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Connexins in the control of vasomotor function
Acta Physiologica, 2018Vascular endothelial cells, as well as smooth muscle cells, show heterogeneity with regard to their receptor expression and reactivity. For the vascular wall to act as a functional unit, the various cells’ responses require integration.
K. Pogoda +3 more
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Biology of the Cell, 2002
Summry— Connexin channels clustered at gap junctions are obligatory attributes of all macroscopic endocrine and exocrine glands investigated so far and also connect most types of cells which produce secretory products in other tissues. Increasing evidence indicates that connexins, and the cell‐to‐cell communications that these proteins permit ...
Serre Beinier, Véronique +8 more
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Summry— Connexin channels clustered at gap junctions are obligatory attributes of all macroscopic endocrine and exocrine glands investigated so far and also connect most types of cells which produce secretory products in other tissues. Increasing evidence indicates that connexins, and the cell‐to‐cell communications that these proteins permit ...
Serre Beinier, Véronique +8 more
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Connexin-30 Deletion Analysis in Connexin-26 Heterozygotes
Genetic Testing, 2003Mutations in the Connexin-26 gene (Cx 26, GJB2) are the most common cause of hereditary nonsyndromic sensorineural hearing loss (SNHL). DNA analysis of the Cx 26 gene in deaf or hard-of-hearing individuals frequently demonstrates heterozygosity despite the fact that most mutations are known to be recessive. A 342-kb deletion in a gene adjacent to Cx 26,
Victoria A, Stevenson +2 more
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