Results 211 to 220 of about 14,893 (256)
Panx1 and drug discovery: from non-specific inhibitors to tailored drug compounds. [PDF]
Cell Tissue ResKohr M, Meier C.
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History of Gap Junction Architecture and Potential Role of Calmodulin in Channel Arrays. [PDF]
Int J Mol SciPeracchia C.
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Regulation of cardiovascular connexins by mechanical forces and junctions
Cardiovascular Research, 2013 Connexins form a family of transmembrane proteins that consists of 20 members in humans and 21 members in mice. Six connexins assemble into a connexon that can function as a hemichannel or connexon that can dock to a connexon expressed by a neighbouring ...
Anna Pfenniger +2 more
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Role of connexins and pannexins in cardiovascular physiology
Cellular and Molecular Life Sciences, 2015 Connexins and pannexins form connexons, pannexons and membrane channels, which are critically involved in many aspects of cardiovascular physiology.
Merlijn Meens +2 more
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Connexins participate in the initiation and progression of atherosclerosis
Seminars in Immunopathology, 2009 Connexins are members of a large family of transmembrane proteins that form hemichannels or gap junctions. These channels allow the exchange of ions and small metabolites between the cytosol and extracellular space or between neighboring cells. Connexins
Laurent Burnier +2 more
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Cell and Tissue Research, 2014
Connexins are essential in the propagation of electrical activity throughout the heart and are an important determinant of conduction velocity. Their dysfunction is an important factor in the genesis of abnormal cardiac rhythm and is relevant to the pathogenesis of a wide variety of cardiac pathologies. Here, we review the basic biology of connexins in
Andrew Tinker, Lambiase Pd
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Connexins are essential in the propagation of electrical activity throughout the heart and are an important determinant of conduction velocity. Their dysfunction is an important factor in the genesis of abnormal cardiac rhythm and is relevant to the pathogenesis of a wide variety of cardiac pathologies. Here, we review the basic biology of connexins in
Andrew Tinker, Lambiase Pd
exaly +3 more sources
Connexins and their channels in inflammation [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2016 Inflammation may be caused by a variety of factors and is a hallmark of a plethora of acute and chronic diseases. The purpose of inflammation is to eliminate the initial cell injury trigger, to clear out dead cells from damaged tissue and to initiate tissue regeneration.
Mathieu Vinken +2 more
exaly +6 more sources
Biology of the Cell, 2002
Summry— The hypothesis, that gap junctional intercellular communication plays a key role in carcinogenesis and more generally in growth control was formulated nearly 40 years ago. From this time, data accumulated, showing that this type of communication is frequently decreased or absent in cells treated with tumor promoting agents, among transformed ...
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Summry— The hypothesis, that gap junctional intercellular communication plays a key role in carcinogenesis and more generally in growth control was formulated nearly 40 years ago. From this time, data accumulated, showing that this type of communication is frequently decreased or absent in cells treated with tumor promoting agents, among transformed ...
openaire +2 more sources
Trends in Cardiovascular Medicine, 1992
Gap junctions are specialized regions of adjoining cell membranes composed of numerous intercellular low-resistance channels. In the heart, these channels electrotonically couple adjacent myocytes and synchronize the cardiac action potential. Signaling through gap junction channels may also influence embryogenesis and development.
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Gap junctions are specialized regions of adjoining cell membranes composed of numerous intercellular low-resistance channels. In the heart, these channels electrotonically couple adjacent myocytes and synchronize the cardiac action potential. Signaling through gap junction channels may also influence embryogenesis and development.
openaire +2 more sources