Results 221 to 230 of about 14,893 (256)
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2006
Remodeling of the vascular wall plays a central role in many physiological processes, but also in the pathogenesis of cardiovascular diseases such as atherosclerosis and restenosis. Atherosclerosis represents the major cause of death and disability in adult populations of Western societies.
Chadjichristos, Christos +2 more
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Remodeling of the vascular wall plays a central role in many physiological processes, but also in the pathogenesis of cardiovascular diseases such as atherosclerosis and restenosis. Atherosclerosis represents the major cause of death and disability in adult populations of Western societies.
Chadjichristos, Christos +2 more
openaire +4 more sources
Connexins and Cardiac Arrhythmias
2006During cardiac remodeling, impulse conduction in the heart is altered by changes in excitability, electrical coupling, and tissue architecture. The impairment of normal impulse conduction is one of the factors that increases the propensity for arrhythmias. This chapter focuses on the relationship between electrical coupling between ventricular myocytes
van Rijen, Harold V. M. +4 more
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Biochimie, 2010
The role of gap junctions in proliferation, differentiation and apoptosis has been recently highlighted. Nevertheless, the molecular mechanisms that control these physiological events by acting on gap junction channels are still unknown. We have recently demonstrated that heteromeric gap junction plaques composed by Cx43 and Cx33 are unstable at the ...
Diane, Carette +3 more
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The role of gap junctions in proliferation, differentiation and apoptosis has been recently highlighted. Nevertheless, the molecular mechanisms that control these physiological events by acting on gap junction channels are still unknown. We have recently demonstrated that heteromeric gap junction plaques composed by Cx43 and Cx33 are unstable at the ...
Diane, Carette +3 more
openaire +2 more sources
Connexin-30 Deletion Analysis in Connexin-26 Heterozygotes
Genetic Testing, 2003Mutations in the Connexin-26 gene (Cx 26, GJB2) are the most common cause of hereditary nonsyndromic sensorineural hearing loss (SNHL). DNA analysis of the Cx 26 gene in deaf or hard-of-hearing individuals frequently demonstrates heterozygosity despite the fact that most mutations are known to be recessive. A 342-kb deletion in a gene adjacent to Cx 26,
Victoria A, Stevenson +2 more
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The TSG101 protein binds to connexins and is involved in connexin degradation
Experimental Cell Research, 2009Gap junctions mediate electrical and metabolic communication between cells in almost all tissues and are proposed to play important roles in cellular growth control, differentiation and embryonic development. Gap junctional communication and channel assembly were suggested to be regulated by interaction of connexins with different proteins including ...
Tanja, Auth +8 more
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Connexins and the gap in context
Integrative Biology, 2011Gap junctions (GJ) can no longer be thought of as simple channel forming structures that mediate intercellular communication. Hemi-channel and channel-independent functions of connexins (Cxs) have been described and numerous Cx interacting partners have been uncovered ranging from enzymes to structural and scaffolding molecules to transcription factors.
R M, Mroue, M E, El-Sabban, R S, Talhouk
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The vertebrate connexin family
Cellular and Molecular Life Sciences, 2006Connexins are chordate-specific transmembrane proteins that can form gap junctional channels between adjacent cells. With the progress in vertebrate genome sequencing, it is now possible to reconstruct the main lines in the evolution of the connexin family from fishes to mammals. Four connexin groups are only found in fishes. Otherwise, the differences
V, Cruciani, S-O, Mikalsen
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Life Cycle of Connexins: Regulation of Connexin Synthesis and Degradation
2006Gap-junction-forming connexins (Cx) exhibit a complex life cycle which is regulated at various levels. First, the promoter regions and binding of transcription factors to them control the transcription of the connexin genes. Translation of Cx-mRNA seems to be enabled by internal ribosome entry site elements allowing translation even under stress ...
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2010
Non-healing cutaneous wounds such as leg ulcers are a major cause of morbidity and mortality, especially in diabetes. Currently 67% of ulcers fail to respond to treatment after 20 weeks of care, and are a substantial time and cost burden. Recent studies suggest significant increases in skin wound healing rates occur by reduction of connexin (Cx ...
Wright, Catherine, Martin, Patricia
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Non-healing cutaneous wounds such as leg ulcers are a major cause of morbidity and mortality, especially in diabetes. Currently 67% of ulcers fail to respond to treatment after 20 weeks of care, and are a substantial time and cost burden. Recent studies suggest significant increases in skin wound healing rates occur by reduction of connexin (Cx ...
Wright, Catherine, Martin, Patricia
openaire +1 more source