Results 1 to 10 of about 1,008 (160)

Usage of Cell-Free Protein Synthesis in Post-Translational Modification of μ-Conopeptide PIIIA [PDF]

Marine Drugs, 2023
The post-translational modifications of conopeptides are the most complicated modifications to date and are well-known and closely related to the activity of conopeptides.
Yanli Liu, Zitong Zhao, Yunyang Song, Yifeng Yin, Fanghui Wu, Hui Jiang   +5 more
doaj   +3 more sources

Single-Disulfide Conopeptide Czon1107, an Allosteric Antagonist of the Human α3β4 Nicotinic Acetylcholine Receptor [PDF]

Marine Drugs, 2022
Conopeptides are peptides in the venom of marine cone snails that are used for capturing prey or as a defense against predators. A new cysteine-poor conopeptide, Czon1107, has exhibited non-competitive inhibition with an undefined allosteric mechanism in
Yuan Ma, Qiushi Cao, Mengke Yang, Yue Gao, Shuiping Fu, Wenhao Du, David J. Adams, Tao Jiang, Han-Shen Tae, Rilei Yu   +9 more
doaj   +3 more sources

The Conopeptide αD-FrXXA, an Inhibitor of Voltage-Gated Potassium Channels [PDF]

Marine Drugs
The conopeptide αD-FrXXA was previously isolated by our team from the venom of the vermivorous snail Conus fergusoni. This toxin is composed of two chains of 47 amino acids and inhibits neuronal and muscular subtypes of nAChR.
Luis Martínez-Hernández, Estuardo López-Vera, Ximena C. Rodriguez-Ruiz, Mónica A. Ortíz-Arellano   +3 more
doaj   +3 more sources

Redox-Active Conopeptide Li520 Has Evolved to Catalyze Oxidative Folding of Conotoxins [PDF]

ACS Omega
The evolution of miniature conopeptide Li520 (COWC*, *: C-terminal amidation) to exhibit the disulfide isomerase activity was probed using structure, function, disulfide conformation, and the precursor gene sequence. The peptides Li520, Li504, [O2A]Li520,
Shweta Dhannura, Shamasoddin Shekh, Pooja Dhurjad, Ashwini Dolle, Sreepriya Kakkat, Vishwajyothi, Marimuthu Vijayasarathy, Rajesh Sonti, Konkallu Hanumae Gowd   +8 more
doaj   +3 more sources

Bibliometric Review of the Literature on Cone Snail Peptide Toxins from 2000 to 2022 [PDF]

Marine Drugs, 2023
The venom of marine cone snails is mainly composed of peptide toxins called conopeptides, among which conotoxins represent those that are disulfide-rich.
Linh T. T. Nguyen, David J. Craik, Quentin Kaas   +2 more
doaj   +2 more sources

κO-SrVIA Conopeptide, a Novel Inhibitor Peptide for Two Members of the Human EAG Potassium Channel Family [PDF]

Int J Mol Sci, 2023
The first conotoxin affecting the voltage-gated potassium channels of the EAG family was identified and characterized from the venom of the vermivorous species Conus spurius from the Gulf of Mexico.
L. Martínez-Hernández, E. López-Vera, M. Aguilar, Ximena C. Rodriguez-Ruiz, M. A. Ortíz-Arellano   +4 more
semanticscholar   +2 more sources

High conopeptide diversity in Conus striatus: Revealed by integration of two transcriptome sequencing platforms

Frontiers in Marine Science, 2022
Marine cone snail venoms represent a vast library of bioactive peptides with proven potential as research tools, drug leads, and therapeutics. In this study, a transcriptome library of four different organs, namely radular sheath, venom duct, venom gland,
Yanling Liao, Chao Peng, Chao Peng, Yabing Zhu, Jinxing Fu, Zhiqiang Ruan, Qiong Shi, Qiong Shi, Bingmiao Gao   +8 more
doaj   +2 more sources

Analysis of venom gland transcriptomes from two Tesseliconus species, Conus eburneus and Conus tessulatus, reveals inter- and intra-specific variations in conopeptide diversity and expression as well as putative novel gene superfamilies and disulfide-poor venom components

Frontiers in Marine Science
The Conus subgenus Tesseliconus, whose members are believed to be primarily worm-hunters, phylogenetically clusters closely with piscivorous groups relative to most other vermivorous subgenera. A previous study even documented the Tesseliconus species C.
Francis A. Tablizo, Francis A. Tablizo, Dan Jethro M. Masacupan, Dan Jethro M. Masacupan, Arturo O. Lluisma   +4 more
doaj   +2 more sources

Characterization of a Novel Conus bandanus Conopeptide Belonging to the M-Superfamily Containing Bromotryptophan

Marine Drugs, 2014
A novel conotoxin (conopeptide) was biochemically characterized from the crude venom of the molluscivorous marine snail, Conus bandanus (Hwass in Bruguière, 1792), collected in the south-central coast of Vietnam.
Bao Nguyen, Jean-Pierre Le Caer, Gilles Mourier, Robert Thai, Hung Lamthanh, Denis Servent, Evelyne Benoit, Jordi Molgó   +7 more
doaj   +2 more sources

Diversity of Conopeptides and Conoenzymes from the Venom Duct of the Marine Cone Snail Conus bayani as Determined from Transcriptomic and Proteomic Analyses

Marine Drugs, 2021
Marine cone snails are predatory gastropods characterized by a well-developed venom apparatus and highly evolved hunting strategies that utilize toxins to paralyze prey and defend against predators.
Rajesh Rajaian Pushpabai, Carlton Ranjith Wilson Alphonse, Rajasekar Mani, Deepak Arun Apte, Jayaseelan Benjamin Franklin   +4 more
doaj   +1 more source