Results 111 to 120 of about 1,008 (160)

Voltage-Gated K⁺ Channel Modulation by Marine Toxins: Pharmacological Innovations and Therapeutic Opportunities. [PDF]

Mar Drugs
Turcio R, Di Matteo F, Capolupo I, Ciaglia T, Musella S, Di Chio C, Stagno C, Campiglia P, Bertamino A, Ostacolo C.   +9 more
europepmc   +1 more source

Nicotinic Receptors in Human Chromaffin Cells: Characterization, Functional and Physical Interactions between Subtypes and Regulation. [PDF]

Int J Mol Sci
Jiménez-Pompa A, Albillos A.
europepmc   +1 more source

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Structure-aided function assignment to the transcriptomic conopeptide Am931.

Toxicon
Implementation of the next-generation technologies for gene sequencing of venom duct transcriptome has provided a large number of peptide sequences of marine cone snails.
Shamasoddin Shekh, Shweta Dhannura, Pooja Dhurjad, C. Ravali, Spoorti M M, Sreepriya Kakkat, Vishwajyothi, Marimuthu Vijayasarathy, Rajesh Sonti, K. H. Gowd   +9 more
semanticscholar   +3 more sources

The Redox-Active Conopeptide Derived from the Venom Duct Transcriptome of Conus lividus Assists in the Oxidative Folding of Conotoxin.

Biochemistry, 2021
The tetrapeptides Li504 and Li520, differing in the modification of the 4-trans-hydroxylation of proline, are novel conopeptides derived from the venom duct transcriptome of the marine cone snail Conus lividus.
A. Dolle, M. Vijayasarathy, Shamasoddin Shekh, Y. Hunashal, K. K. A. Reddy, Sunita Prakash, Abhijit Rana, Himansu S. Biswal, S. Raghothama, K. H. Gowd   +9 more
semanticscholar   +1 more source

Therapeutic Potential of Conopeptides

Future Medicinal Chemistry, 2012
Conopeptides from the venoms of marine snails have attracted much interest as leads in drug design. Currently, one drug, Prialt(®), is on the market as a treatment for chronic neuropathic pain. Conopeptides target a range of ion channels, receptors and transporters, and are typically small, relatively stable peptides that are generally amenable to ...
Schroeder, Christina I., Craik, David J.
openaire   +3 more sources

Simulation of differential structure and dynamics of disulfide bond isoforms of conopeptide AuIB in presence of human α3β4 nAChR

, 2021
The structure and function of conopeptides are usually strongly modulated by disulfide bond linkage patterns. Conopeptide AuIB is a selective inhibitor of the mammalian α3β4 nicotinic acetylcholine receptor (nAChR), found in the neuromuscular junctions ...
Karuna Anna Sajeevan, Durba Roy
semanticscholar   +1 more source

Conopeptides: From deadly venoms to novel therapeutics

Drug Discovery Today, 2000
Marine cone snails have developed many distinct venoms that contain biologically active peptides as part of an envenomation survival strategy for feeding and defense. These peptides, known as conopeptides, have been optimized through evolution to target specific ion channels and receptors with very high affinities and selectivities.
, Shen, , Layer, , McCabe
openaire   +2 more sources

Towards an integrated venomics approach for accelerated conopeptide discovery.

Toxicon, 2012
Conopeptides and conotoxins are small peptides produced by cone snails as a part of their predatory/defense strategies that target key ion channels and receptors in the nervous system. Some of these peptides also potently target mammalian ion channels involved in pain pathways.
Jutty Rajan Prashanth, R. Lewis, S. Dutertre   +2 more
semanticscholar   +4 more sources

Drugs from Slugs. Part II – Conopeptide bioengineering

Chemico-Biological Interactions, 2012
The biological transformation of toxins as research probes, or as pharmaceutical drug leads, is an onerous and drawn out process. Issues regarding changes to pharmacological specificity, desired potency, and bioavailability are compounded naturally by their inherent toxicity.
Jon-Paul, Bingham, Elizabeth A, Andrews, Shaun M, Kiyabu, Chino C, Cabalteja   +3 more
openaire   +2 more sources