Results 11 to 20 of about 1,008 (160)
Improved prediction of conopeptide superfamilies with ConoDictor 2.0 [PDF]
Bioinformatics Advances, 2021 Motivation Cone snails are among the richest sources of natural peptides with promising pharmacological and therapeutic applications. With the reduced costs of RNAseq, scientists now heavily rely on venom gland transcriptomes for the mining of novel ...
Dominique Koua +2 more
semanticscholar +4 more sources
Side‐chain dynamics of the α1B‐adrenergic receptor determined by NMR via methyl relaxation [PDF]
Protein Science, Volume 32, Issue 11, November 2023., 2023 Abstract G protein‐coupled receptors (GPCRs) are medically important membrane proteins that sample inactive, intermediate, and active conformational states characterized by relatively slow interconversions (~μs–ms). On a faster timescale (~ps–ns), the conformational landscape of GPCRs is governed by the rapid dynamics of amino acid side chains.
Christian Baumann +8 more
wiley +2 more sources
High-Throughput Prediction and Design of Novel Conopeptides for Biomedical Research and Development [PDF]
BioDesign Research, 2022 Cone snail venoms have been considered a valuable treasure for international scientists and businessmen, mainly due to their pharmacological applications in development of marine drugs for treatment of various human diseases.
Bingmiao Gao +7 more
doaj +2 more sources
Conopeptides from Cape Verde Conus crotchii [PDF]
Marine Drugs, 2013 Marine Cone snails of the genus Conus contain complex peptide toxins in their venom. Living in tropical habitats, they usually use the powerful venom for self-defense and prey capture.
Agostinho Antunes +4 more
doaj +3 more sources
ConoMode, a database for conopeptide binding modes
Database, 2020 ConoMode is a database for complex three-dimensional (3D) structures of conopeptides binding with their target proteins. Conopeptides, a large family of peptides from the venom of marine snails of the Conus genus, have exceptionally diverse sequences ...
Xiao Li +9 more
semanticscholar +3 more sources
The macrocycle inhibitor landscape of SLC‐transporter [PDF]
Molecular Informatics, Volume 43, Issue 5, May 2024.Abstract In the past years the interest in Solute Carrier Transporters (SLC) has increased due to their potential as drug targets. At the same time, macrocycles demonstrated promising activities as therapeutic agents. However, the overall macrocycle/SLC‐transporter interaction landscape has not been fully revealed yet.
Nejra Granulo +3 more
wiley +2 more sources
Hormone-like conopeptides – new tools for pharmaceutical design [PDF]
RSC Medicinal Chemistry, 2020 Marine cone snails produce an array of hormone-like peptides in their venom, providing bioactive leads for developing peptide drugs and small molecule mimetics.
Ashlin Turner +2 more
openaire +4 more sources
Identification of Novel Conotoxin Precursors from the Cone Snail Conus spurius by High-Throughput RNA Sequencing [PDF]
Marine Drugs, 2021 Marine gastropods of the genus Conus, comprising more than 800 species, have the characteristic of injecting worms and other prey with venom. These conopeptide toxins, highly diverse in structure and action, are highly potent and specific for their ...
Roberto Zamora-Bustillos +4 more
doaj +2 more sources
Advanced ScienceThe δ‐conotoxins, a class of peptides produced in the venom of cone snails, are of interest due to their ability to inhibit the inactivation of voltage‐gated sodium channels causing paralysis and other neurological responses, but difficulties in their ...
Stephen McCarthy, Shane Gonen
doaj +2 more sources
The first Conus genome assembly reveals a primary genetic central dogma of conopeptides in C. betulinus [PDF]
Cell Discovery, 2021 Although there are various Conus species with publicly available transcriptome and proteome data, no genome assembly has been reported yet. Here, using Chinese tubular cone snail (C.
Chao Peng +24 more
doaj +2 more sources