Results 31 to 40 of about 1,008 (160)

High‐resolution crystal structure of the Mu8.1 conotoxin from Conus mucronatus

Acta Crystallographica Section F, Volume 79, Issue 9, Page 240-246, September 2023., 2023
The crystal structure of the Mu8.1 conotoxin was determined in the high‐symmetry space group I4122 at 1.67 Å resolution. This crystal structure reveals a surface‐exposed Zn2+‐binding site and establishes a hydrogen‐bonding network around Lys55 buried at the dimer interface.Marine cone snails produce a wealth of peptide toxins (conotoxins) that bind ...
Emilie Müller, Celeste Menuet Hackney, Lars Ellgaard, Jens Preben Morth   +3 more
wiley   +1 more source

Identification of Conomarphin Variants in the Conus eburneus Venom and the Effect of Sequence and PTM Variations on Conomarphin Conformations

Marine Drugs, 2020
Marine cone snails belonging to the Conidae family make use of neuroactive peptides in their venom to capture prey. Here we report the proteome profile of the venom duct of Conus eburneus, a cone snail belonging to the Tesseliconus clade.
Corazon Ericka Mae M. Itang, Jokent T. Gaza, Dan Jethro M. Masacupan, Dessa Camille R. Batoctoy, Yu-Ju Chen, Ricky B. Nellas, Eizadora T. Yu   +6 more
doaj   +1 more source

Tyrosine-rich Conopeptides Affect Voltage-gated K+ Channels [PDF]

Journal of Biological Chemistry, 2008
Two venom peptides, CPY-Pl1 (EU000528) and CPY-Fe1 (EU000529), characterized from the vermivorous marine snails Conus planorbis and Conus ferrugineus, define a new class of conopeptides, the conopeptide Y (CPY) family. The peptides have no disulfide cross-links and are 30 amino acids long; the high content of tyrosine is unprecedented for any native ...
Imperial, Julita S., Chen, Ping, Sporning, Annett, Terlau, Heinrich, Daly, Norelle L., Craik, David J., Alewood, Paul F., Olivera, Baldormero M.   +7 more
openaire   +4 more sources

Synthesis and evaluation of a novel analgesic conotoxin Lt7b that inhibits calcium currents and increases sodium currents

Journal of Cellular and Molecular Medicine, Volume 26, Issue 20, Page 5330-5334, October 2022., 2022
Abstract Conotoxins are promising neuropharmacological tools and drug candidates due to their high efficiency and specificity in targeting ion channels or neurotransmitter receptors. In this study, a novel O2‐superfamily conotoxin, Lt7b, was synthesized and its pharmacological functions were evaluated.
Yun Wu, Manyi Yang, Yubin Li, Wei Zhang, Maojun Zhou   +4 more
wiley   +1 more source

Molecular Phylogeny, Classification and Evolution of Conopeptides [PDF]

Journal of Molecular Evolution, 2012
Conopeptides are toxins expressed in the venom duct of cone snails (Conoidea, Conus). These are mostly well-structured peptides and mini-proteins with high potency and selectivity for a broad range of cellular targets. In view of these properties, they are widely used as pharmacological tools and many are candidates for innovative drugs.
Puillandre, N., Koua, D., Favreau, P., Olivera, B., Stöcklin, R.   +4 more
openaire   +5 more sources

Discovery of KV1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges

Medicinal Research Reviews, Volume 41, Issue 4, Page 2423-2473, July 2021., 2021
Abstract The KV1.3 voltage‐gated potassium ion channel is involved in many physiological processes both at the plasma membrane and in the mitochondria, chiefly in the immune and nervous systems. Therapeutic targeting KV1.3 with specific peptides and small molecule inhibitors shows great potential for treating cancers and autoimmune diseases, such as ...
Špela Gubič, Louise A. Hendrickx, Žan Toplak, Maša Sterle, Steve Peigneur, Tihomir Tomašič, Luis A. Pardo, Jan Tytgat, Anamarija Zega, Lucija P. Mašič   +9 more
wiley   +1 more source

Identification of Novel Conopeptides and Distinct Gene Superfamilies in the Marine Cone Snail Conus quercinus

Frontiers in Marine Science, 2021
Conopeptides from the marine cone snails are a mixture of cysteine-rich active peptides, representing a unique and fertile resource for neuroscience research and drug discovery.
Han Zhang, Han Zhang, Han Zhang, Lei Wang, Xiang Yang, Xiang Yang, Xiang Yang, Zhiwei Lian, Zhiwei Lian, Yinbin Qiu, Yinbin Qiu, Zhanying Dong, Zhanying Dong, Xuedong Wu, Xuedong Wu, Xinghua Pan, Xinghua Pan, Xinghua Pan, Xinghua Pan   +18 more
doaj   +1 more source

ConoDictor: a tool for prediction of conopeptide superfamilies [PDF]

Nucleic Acids Research, 2012
ConoDictor is a tool that enables fast and accurate classification of conopeptides into superfamilies based on their amino acid sequence. ConoDictor combines predictions from two complementary approaches-profile hidden Markov models and generalized profiles. Results appear in a browser as tables that can be downloaded in various formats.
Koua, Dominique, Brauer, Age, Laht, Silja, Kaplinski, Lauris, Favreau, Philippe, Remm, Maido, Lisacek, Frédérique, Stöcklin, Reto   +7 more
openaire   +2 more sources

A novel proline-rich M-superfamily conotoxin that can simultaneously affect sodium, potassium and calcium currents

Journal of Venomous Animals and Toxins including Tropical Diseases, 2021
Background Conotoxins have become a research hotspot in the neuropharmacology field for their high activity and specificity in targeting ion channels and neurotransmitter receptors.
Manyi Yang, Yubin Li, Longfei Liu, Maojun Zhou   +3 more
doaj   +1 more source

Conopeptides promote itch through human itch receptor hMgprX1 [PDF]

Toxicon, 2018
Members of Mas related G-protein coupled receptors (Mrgpr) are known to mediate itch. To date, several compounds have been shown to activate these receptors, including chloroquine, a common antimalarial drug, and peptides of the RF-amide family. However, specific ligands for these receptors are still lacking and there is a need for novel compounds that
Espino, Samuel S., Robinson, Samuel D., Safavi-Hemami, Helena, Gajewiak, Joanna, Yang, Weishan, Olivera, Baldomero M., Liu, Qin   +6 more
openaire   +3 more sources