Results 41 to 50 of about 1,008 (160)

Curses or Cures: A Review of the Numerous Benefits Versus the Biosecurity Concerns of Conotoxin Research

Biomedicines, 2020
Conotoxins form a diverse group of peptide toxins found in the venom of predatory marine cone snails. Decades of conotoxin research have provided numerous measurable scientific and societal benefits.
Walden E. Bjørn-Yoshimoto, Iris Bea L. Ramiro, Mark Yandell, J. Michael McIntosh, Baldomero M. Olivera, Lars Ellgaard, Helena Safavi-Hemami   +6 more
doaj   +1 more source

Conopeptide-Functionalized Nanoparticles Selectively Antagonize Extrasynaptic N-Methyl-d-aspartate Receptors and Protect Hippocampal Neurons from Excitotoxicity In Vitro.

ACS Nano, 2020
N-methyl-d-aspartate receptors (NMDARs) are ionotropic glutamate receptors controlling fundamental physiological processes in the central nervous system, such as learning and memory.
P. Valente, D. Kiryushko, Silvio Sacchetti, P. Machado, C. Cobley, V. Mangini, A. Porter, J. Spatz, R. Fleck, F. Benfenati, R. Fiammengo   +10 more
semanticscholar   +1 more source

Mechanisms for Evolving Hypervariability: The Case of Conopeptides [PDF]

Molecular Biology and Evolution, 2001
Hypervariability is a prominent feature of large gene families that mediate interactions between organisms, such as venom-derived toxins or immunoglobulins. In order to study mechanisms for evolution of hypervariability, we examined an EST-generated assemblage of 170 distinct conopeptide sequences from the venoms of five species of marine Conus snails.
S G, Conticello, Y, Gilad, N, Avidan, E, Ben-Asher, Z, Levy, M, Fainzilber   +5 more
openaire   +2 more sources

Conotoxin Gene Superfamilies

Marine Drugs, 2014
Conotoxins are the peptidic components of the venoms of marine cone snails (genus Conus). They are remarkably diverse in terms of structure and function. Unique potency and selectivity profiles for a range of neuronal targets have made several conotoxins
Samuel D. Robinson, Raymond S. Norton
doaj   +1 more source

ConoServer, a database for conopeptide sequences and structures [PDF]

Bioinformatics, 2007
Abstract Summary: ConoServer is a new database dedicated to conopeptides, a large family of peptides found in the venom of marine snails of the genus Conus. These peptides have an exceptional diversity of sequences and chemical modifications and their ability to block ion channels makes them important as drug leads and tools for ...
Kaas, Quentin, Westermann, Jan, Halai, Reena, Wang, Conan, Craik, David J.   +4 more
openaire   +3 more sources

Expression of α3β2β4 nicotinic acetylcholine receptors by rat adrenal chromaffin cells determined using novel conopeptide antagonists

Journal of Neurochemistry, 2020
Adrenal chromaffin cells release neurotransmitters in response to stress and may be involved in conditions such as post‐traumatic stress and anxiety disorders.
Arik J. Hone, Lola Rueda-Ruzafa, T. Gordon, J. Gajewiak, Sean B. Christensen, T. Dyhring, A. Albillos, J. McIntosh   +7 more
semanticscholar   +1 more source

Engineered biosynthesis of cyclotides

New Zealand Journal of Botany, Volume 58, Issue 4, Page 358-377, December 2020., 2020
ABSTRACT A system based on cyanobacterial split inteins, SICLOPPs (Split Intein Circular Ligation of Proteins and Peptides), has been used to synthesise a small natively cyclic plant protein, kalata B1, and cyclised versions of the natively linear therapeutic peptides ziconotide and leconotide.
Thomas N. G. Handley, Hyon‐Xhi Tan, Malcolm T. Rutledge, Hans Henning Brewitz, Joel D. A. Tyndall, Torsten Kleffmann, Margi I. Butler, Russell T. M. Poulter, Sigurd M. Wilbanks   +8 more
wiley   +1 more source

Discovery of 194 Unreported Conopeptides and Identification of a New Protein Disulfide Isomerase in Conus caracteristicus Using Integrated Transcriptomic and Proteomic Analysis

Frontiers in Marine Science, 2022
Current ConoServer database accumulates 8,134 conopeptides from 122 species of cone snail, which are pharmaceutically attractive marine resource. However, many more conopeptides remain to be discovered, and the enzymes involved in their synthesis and ...
Han Zhang, Han Zhang, Han Zhang, Lei Wang, Yinbin Qiu, Yinbin Qiu, Yinbin Qiu, Fahui Gong, Baoting Nong, Xinghua Pan, Xinghua Pan, Xinghua Pan   +11 more
doaj   +1 more source

Transcriptomic-Proteomic Correlation in the Predation-Evoked Venom of the Cone Snail, Conus imperialis

Marine Drugs, 2019
Individual variation in animal venom has been linked to geographical location, feeding habit, season, size, and gender. Uniquely, cone snails possess the remarkable ability to change venom composition in response to predatory or defensive stimuli.
Ai-Hua Jin, Sébastien Dutertre, Mriga Dutt, Vincent Lavergne, Alun Jones, Richard J. Lewis, Paul F. Alewood   +6 more
doaj   +1 more source

Structure and allosteric activity of a single-disulfide conopeptide from Conus zonatus at human α3β4 and α7 nicotinic acetylcholine receptors

Journal of Biological Chemistry, 2020
Conopeptides are neurotoxic peptides in the venom of marine cone snails and have broad therapeutic potential for managing pain and other conditions. Here, we identified the single-disulfide peptides Czon1107 and Cca1669 from the venoms of Conus zonatus ...
M. Mohan, N. Abraham, Rajesh R P, Benjamin Franklin Jayaseelan, L. Ragnarsson, R. Lewis, S. Sarma   +6 more
semanticscholar   +1 more source