Results 171 to 180 of about 4,686 (201)
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Conotoxins: natural product drug leads
Natural Product Reports, 2009Venomous marine cone snails harbour a variety of small disulfide-rich peptides called conotoxins, which target a broad range of ion channels, membrane receptors, and transporters. More than 700 species of Conus are thought to exist, each expressing a wide array of different peptides.
Halai, Reena, Craik, David J.
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Proceedings of the 2019 3rd International Conference on Computational Biology and Bioinformatics, 2019
Conopeptides are small, disulfide-rich polypeptides that have great potential as sources of possible drug candidates due to their activity against membrane receptors and ion channels. A challenge to the faster high-throughput in silico screening of these potential drug candidates is their diversity in structure and relatively low sequence similarity ...
Marineil C. Gomez +5 more
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Conopeptides are small, disulfide-rich polypeptides that have great potential as sources of possible drug candidates due to their activity against membrane receptors and ion channels. A challenge to the faster high-throughput in silico screening of these potential drug candidates is their diversity in structure and relatively low sequence similarity ...
Marineil C. Gomez +5 more
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The international journal of biochemistry & cell biology, 2000
alpha-Conotoxins (alpha-CgTxs) are a family of Cys-enriched peptides found in several marine snails from the genus Conus. These small peptides behave pharmacologically as competitive antagonists of the nicotinic acetylcholine receptor (AChR). The data indicate that (1) alpha-CgTxs are able to discriminate between muscle- and neuronal-type AChRs and ...
H R, Arias, M P, Blanton
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alpha-Conotoxins (alpha-CgTxs) are a family of Cys-enriched peptides found in several marine snails from the genus Conus. These small peptides behave pharmacologically as competitive antagonists of the nicotinic acetylcholine receptor (AChR). The data indicate that (1) alpha-CgTxs are able to discriminate between muscle- and neuronal-type AChRs and ...
H R, Arias, M P, Blanton
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Conotoxin Venom Peptide Therapeutics
2009Venom peptides offer enormous opportunity for the discovery of peptide drug leads. This review focusses on the potential of cone snails that have developed arrays of small peptides as part of highly evolved venoms used for prey capture and defence. Many of these peptides selectively modulate ion channels and transporters, making them a valuable source ...
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Structure-Activity Studies on Alpha-Conotoxins
Current Pharmaceutical Design, 2011Conotoxins are small bioactive highly structured peptides from the venom of marine cone snails (genus Conus). Over the past 50 million years these molluscs have developed a complex venom cocktail for each species that is comprised of 100-2000 distinct cysteine- rich peptides for prey capture and defence.
Muttenthaler, Markus +2 more
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Conotoxins-New Vistas for Peptide Therapeutics
Current Pharmaceutical Design, 2000There are approximately 500 species of predatory cone snails within the genus Conus. They comprise what is arguably the largest single genus of marine animals alive today. It has been estimated that the venom of each Conus species has between 50 and 200 components. These highly constrained sulfur rich components or conotoxins represent a unique arsenal
R M, Jones, G, Bulaj
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1997
Abstract The α-conotoxins are probably the largest family of paralytic neurotoxins found in the venoms of cone snails (genus Conus), a very successful group of predatory molluscs comprising c. 500 species (Olivera et al. 1985; Myers et al. 1991).
B Olivera, J M McIntosh
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Abstract The α-conotoxins are probably the largest family of paralytic neurotoxins found in the venoms of cone snails (genus Conus), a very successful group of predatory molluscs comprising c. 500 species (Olivera et al. 1985; Myers et al. 1991).
B Olivera, J M McIntosh
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THE CHARACTERIZATION OF CONOTOXINS§
Journal of Toxicology: Toxin Reviews, 2000Conotoxins are peptide toxins synthesized by marine cone snails for both prey entrapment and defense. The peptides, when injected into the prey, cause immobilization and death. Cone snails are widely distributed in tropical waters, their prey includes fish, worms and other marine snails. The peptide toxins have very high specificity and selectivity for
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1997
Abstract The ω-conotoxins are a major family of paralytic neurotoxins produced in the venoms of various species of marine gastropods belonging to the genus Conus. At this time, the most widely known of these peptides is ω-conotoxin Gv1A (wGv1A), which has 27 amino acids and three disulfide linkages; in many scientific publications, the ...
B M Olivera, J S Imperial, D Yoshikami
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Abstract The ω-conotoxins are a major family of paralytic neurotoxins produced in the venoms of various species of marine gastropods belonging to the genus Conus. At this time, the most widely known of these peptides is ω-conotoxin Gv1A (wGv1A), which has 27 amino acids and three disulfide linkages; in many scientific publications, the ...
B M Olivera, J S Imperial, D Yoshikami
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