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Conotoxins: Molecular and Therapeutic Targets
2009Marine molluscs known as cone snails produce beautiful shells and a complex array of over 50,000 venom peptides evolved for prey capture and defence. Many of these peptides selectively modulate ion channels and transporters, making them a valuable source of new ligands for studying the role these targets play in normal and disease physiology.
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μ-Conotoxins (Conus geographus)
1997Abstract μ-Conotoxins are small basic peptides that inhibit the action potential of skeletal muscle by blocking voltagegated sodium channels (Cruz et al. 1985; Gray et al. 1988). Three major homologues and four minor under hydroxylated forms (see Table 1) have been found in the venom of the most dangerous Conus species, C.
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