Results 91 to 100 of about 1,537,452 (154)

Pediatric high-grade glioma: A heterogeneous group of neoplasms with different molecular drivers

Glioma, 2018
High-grade gliomas (HGGs) in pediatric age have the same bad prognosis as those arising in adults. Approximately one-half of HGGs in children occur in the brain stem, most frequently within the pons as diffuse intrinsic pontine glioma or other midline ...
Francesca Gianno, Manila Antonelli, Elisabetta Ferretti, Maura Massimino, Antonietta Arcella, Felice Giangaspero   +5 more
doaj   +1 more source

Traces of Criminal Records: Digital Reputation and Information Concealment Policy

Law &Policy, Volume 48, Issue 4, October 2026.
ABSTRACT In the United States, a robust data ecosystem aggregates and shares public records about people that may ultimately appear in Internet search results for a person's name. These records can include stigmatizing information and operate outside public policy efforts to conceal negative information from regulated background screening processes ...
Amanda Y. Agan, Sarah E. Lageson
wiley   +1 more source

The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review

Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.
ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo, Miriam A. Bornhorst, Angela J. Waanders, Sara Zarnegar‐Lumley, Ashwin Lakshman Koppayi, Lucy A. Godley   +5 more
wiley   +1 more source

Machine Learning for Synthetic Organic Chemistry: Methods, Applications, and Best Practices

Angewandte Chemie Novit, Volume 2, Issue 3, September 2026.
Artificial intelligence (AI) and machine learning (ML) are increasingly reshaping experimental chemistry. This review maps the challenges of synthetic organic chemistry to modern digital tools that can help address them. While focusing on the practical application of ML tools in real‐world laboratory settings, we outline prerequisites, emerging ...
Niklas Hölter, Felix Katzenburg, Florian Boser, Frank Glorius   +3 more
wiley   +1 more source

Indigenous Entrepreneurship in the Canadian Cannabis Industry: A Media Analysis Explored Through Self‐Determination Theory

Canadian Journal of Administrative Sciences / Revue Canadienne des Sciences de l'Administration, Volume 43, Issue 3, September 2026.
ABSTRACT First Nations in Canada are exercising inherent sovereignty through cannabis entrepreneurship, enacting community‐based regulatory frameworks and asserting jurisdictional authority over economic activities within their territories. Through analyzing 71 Canadian media articles, this study examines how First Nations governance innovation and ...
Tamara Donnelly, Iliana Loupessis
wiley   +1 more source

Position paper: Challenges and specific strategies for constitutional mismatch repair deficiency syndrome in low-resource settings

, 2020
Germline biallelic mutations in one of the mismatch repair genes, mutS homolog 2, mutS homolog 6, mutL homolog 1, or postmeiotic segregation increased 2, result in one of the most aggressive cancer syndromes in humans termed as constitutional mismatch ...
Amayiri, Nisreen, Eric Bouffet, Durno, Carol, Tabori, Uri, Abedalthagafi, Malak, El-Naggar, Shahenda, Rejin Kebudi, Bouffet, Eric, Asım Noor Rana, Lamki, Zakiya Al, Jamila El Houdzi, Hulya Yazici, Rana, Asinn Noor, Zakiya Al Lamki, Naureen Musthaq, Kebudi, Rejin, Musthaq, Naureen, Nisreen Amayiri, Houdzi, Jamila El, Bianchi, Vanessa J., Salman Kirmani, Rana, Asım Noor, Al Lamki, Zakiya, Carol Durno, El Houdzi, Jamila, Vanessa J. Bianchi, Yazici, Hulya, Malak Abedalthagafi, Shahenda El‐Naggar, Kirmani, Salman, Edwards, Melissa, Melissa Edwards, Uri Tabori   +32 more
core   +1 more source

A POLE P286R‐Mutated Hepatoid Adenocarcinoma of the Lung Showing Substantial Response to Immune Checkpoint Inhibition

Cancer Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background Hepatoid adenocarcinoma of the lung (HAL) is a rare form of lung cancer with histological and morphological properties of hepatocellular carcinoma, characterized by an aggressive course of the disease and unfavorable prognosis. Given the rarity of the pathology and the lack of unambiguous therapeutic protocols, descriptions of ...
Aleksey Chernev, Alina Kaurtseva, Ruslan Abasov, Rafael Enikeev, Nina Gegelia, Gulnara Abdrakova, Natalia Usman, Alexander Druy, Grigory Raskin   +8 more
wiley   +1 more source

Functional repair assay for the diagnosis of constitutional mismatch repair deficiency from non-neoplastic tissue

, 2019
Purpose: Constitutional mismatch repair deficiency (CMMRD) is a highly penetrant cancer predisposition syndrome caused by biallelic mutations in mismatch repair (MMR) genes.
Luiten, Rebecca C, Durno, Carol, George, Ben, Hijiya, Nobuko, Pedroza, Luis Alberto, Bouffet, Eric, Lanni, Stella, Gallinger, Steve, Lee, Yi-Yen, Mason, Warren, Mandel, Ariane, Malkin, David, Van Damme, An, Sumerauer, David, Aronson, Melyssa, Bernstein, Mark, Ramdas, Jagadeesh, Shuen, Andrew Y., Yu, Lisa, Farah, Roula, Palma, Laura, Magimairajan, Vanan, Zapotocky, Michal, Foulkes, William D, Nicholas, Garth, Dvir, Rina, Zhang, Cindy, Tabori, Uri, Campbell, Brittany B, Mordechai, Oz, Campbell, Brittany B., Pearson, Christopher E, Samuel, David, Panigrah, Gagan B., Crooks, Bruce, Bowers, Daniel C, Laetsch, Theodore W, Cole, Kristina A, Shamvil, Ashraf, Tomboc, Patrick, Seeley, Andrea, Shuen, Andrew Y, Wolfe Schneider, Kami, Toledano, Helen, Wierman, Margaret, Zhukova, Nataliya, Semotiuk, Kara, Larouche, Valerie, Oren, Michael, Mushtaq, Naureen, Panigrahi, Gagan B, Carroll, Sara, Alharbi, Musa, Lindhorst, Scott, Mason, Gary, Edwards, Melissa, Constantini, Shlomi   +56 more
core   +1 more source

AI‐Accelerated Design and Modeling of Organic Electrochemical Energy Materials: From Redox‐Active Molecules to Polymer Electrolytes

Macromolecular Materials and Engineering, Volume 311, Issue 9, September 2026.
AI is reshaping the design and modeling of organic electrochemical energy materials, from redox‐active molecules to polymer electrolytes. Progress across data‐driven prediction, machine‐learning interatomic potentials, generative models, and agentic workflows is assessed, while persistent challenges in data quality, polymer representation, validation ...
Zhan‐Yun Zhang, Giannis Savvas, Jichen Li, Yue Zhou, Thanh Trung Le, Daniel Brandell, Rocío Mercado, Chao Zhang   +7 more
wiley   +1 more source

Molecular characterization of mismatch repair deficient tumors in young Jordanian patients

Discover Oncology
Mismatch repair deficiency (MMRD) contributes substantially to early-onset colorectal carcinoma (CRC) and pediatric malignancies in Jordan. Approximately 19% of CRCs diagnosed in adults younger than 45 years exhibit MMRD by immunohistochemistry (IHC). In
Olfat Ahmad, Iyad Sultan, Maysa Hussaini, Osama Alsmadi, Christian Sutter, Steffen Hirsch, Robert J. Autry, Christopher Previti, Asta Försti, Benjamin Schwalm, Lama AbuJamous, Nisreen Amayiri, Mayada Abu Shanap, Rola Amareen, Salsabeel Aljawabrah, Lara Fryjat, Aya Al-Naimat, Areen Qaisi, Hala Alnaimat, David E. Reuss, Nicholas R. Fernandez, Anirban Das, Uri Tabori, Stefan M. Pfister, Christian P. Schaaf   +24 more
doaj   +1 more source