Results 51 to 60 of about 1,537,452 (154)

Case report: a rare case of hereditary colorectal cancer and brain tumor with café au lait spots in a child: constitutional mismatch repair deficiency (CMMRD) syndrome

Egyptian Pediatric Association Gazette
Background Colorectal carcinoma (CRC) is rarely seen in the pediatric population. Hereditary cancers due to mismatch repair deficiency cause colorectal, brain, hematological malignancies, and other tumors in early childhood.
Zubair Khurshid, Mishraz Shaikh, Tarek Talaat Harb Elkadi   +2 more
doaj   +1 more source

Clinical and genetic features of pediatric hereditary polyposis syndromes in Israel: A nationwide multicenter cohort

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Hereditary polyposis syndromes in children are rare, heterogeneous disorders associated with significant morbidity and long‐term risk of malignancy. Current data on their presentation, management, and outcomes in pediatric populations remain limited.
Shlomi Cohen, Tal Cozacov, Ilana Weintraub, Ron Shaoul, Oren Ledder, Dotan Yogev, Mordechai Slae, Ranya Egbarieh, Galina Ling, Anat Yerushalmy‐Feler   +9 more
wiley   +1 more source

Cancer prevention by aspirin in children with Constitutional Mismatch Repair Deficiency (CMMRD)

, 2018
\ua9 2018 European Society of Human Genetics Constitutional MisMatch Repair Deficiency (CMMRD) is caused by homozygous or compound heterozygous germline variants in one of the mismatch repair (MMR) genes (MSH2, MSH6, PMS2, MLH1). This syndrome results in
Hoogerbrugge N, Loeffen J, Leenders EKSM, Westdorp H, Bruggemann RJ, Kratz C, Jongmans MCJ, Burn J   +7 more
core   +7 more sources

Reduced patella medialization in valgus and varus knees using a KA‐optimized femoral component in kinematically aligned TKA

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Patellofemoral complications after total knee arthroplasty (TKA) are linked to femoral component design and trochlear alignment. This study compared the effects of a kinematically aligned (KA)‐optimized femoral component versus a standard design on patellofemoral kinematics, contact mechanics and quadriceps function, using native knee ...
Johanna‐Maria Simon, Tara Mauritia Siedow, Christoph Thorwächter, Hannes Traxler, Katharina Kirchhoff, Felix Endres, Boris Michael Holzapfel, Peter Ernst Müller, Thomas Richard Niethammer   +8 more
wiley   +1 more source

Clarifying Public Policy for Stronger Public Administration in Development

Public Administration and Development, EarlyView.
ABSTRACT Public policy is ubiquitous, yet its meaning is often unclear. This ambiguity is not just conceptual. Because policy work is a large part of what public administrations do, how we define policy shapes how we structure and organize our administrative mechanisms.
Matt Andrews
wiley   +1 more source

From Map Follower to Navigator: Archetypes of Environmental Impact Assessment

Systems Research and Behavioral Science, EarlyView.
ABSTRACT Environmental impact assessment (EIA) scholarship is commonly framed as a tension between efficiency and comprehensiveness paradigms. These paradigms describe a persistent tension but cannot explain how EIA operates through it. Drawing on social systems theory, this analysis traces that operation.
Kenneth Kang
wiley   +1 more source

Microstructure Characterization of Bending Effects in 304L Stainless Steel Cladded with Low‐Alloy Steel Weld

steel research international, EarlyView.
Prebending of 304L/Q345R cladded plates significantly alters the subsequent weld thermal cycle and modifies the local interfacial microstructure. Combined electron backscatter diffraction (EBSD) and microscopy analysis demonstrates that deformation twinning, martensitic transformation, and defect initiation are concentrated at the trimaterial junction,
Ali Fahem, Elsiddig Elmukashfi, Hong Dong   +2 more
wiley   +1 more source

The future of regional airports in Australia: Policy challenges

Australian Journal of Public Administration, EarlyView.
Abstract Council‐owned regional airports in Australia face governance challenges that have caused significant financial unsustainability across the sector. Federal policy frameworks fail to address these challenges and risk exacerbating existing pressures by outlining ambitious visions for the adoption of new technologies and achieving net zero.
Linda Wasiela, Michael B. Charles, David Noble   +2 more
wiley   +1 more source

Counterfactuals: Does bureaucracy produce unfair workplaces?

Australian Journal of Public Administration, EarlyView.
Abstract Bureaucracy is often used as a metaphor for organisations that place machine‐like functioning above human needs. In this paper, a mixed‐methods approach is used to investigate the relationship between bureaucracy and fairness in public administration.
Clemens Striebing, Jannick Schneider, Moritz Julian Maier   +2 more
wiley   +1 more source

Functional Characterization of Excision Repair and RecA-Dependent Recombinational DNA Repair in Campylobacter jejuni [PDF]

, 2009
The presence and functionality of DNA repair mechanisms in Campylobacter jejuni are largely unknown. In silico analysis of the complete translated genome of C.
Dep Infectieziekten Immunologie, de Boer, A.G., Graaf-van Bloois, L., van der, Gaasbeek, E.J., Strategic Infection Biology, van Putten, J.P.M., van der Graaf-van Bloois, L., Boer, P., Wagenaar, J.A., Vermaning, B.J., van der Wal, F.J., Wal, F.J., van der, Putten, J.P.M., van, Boer, A.G., de   +13 more
core   +2 more sources