Results 61 to 70 of about 1,537,452 (154)

The Perils of Proportional Representation for Ethnic Minorities

open access: yesThe Political Quarterly, EarlyView.
Abstract Two arguments about ethnic minorities run through the debate over replacing first past the post. One promises that proportional representation would represent minorities better; the other worries that it would empower the parties they have most reason to fear. This article argues that the promise is unreliable and the worry real.
Tarunabh Khaitan
wiley   +1 more source

Hematological malignancies in constitutional mismatch repair deficiency syndrome

open access: yes
Introduction . Constitutional mismatch repair deficiency (CMMRD) syndrome is a rare childhood cancer predisposition syndrome.
V. V. Klyukhin   +6 more
core   +1 more source

Multiple brain developmental venous anomalies as a marker for constitutional mismatch repair deficiency syndrome [PDF]

open access: yes, 2018
The occurrence of multiple developmental venous anomalies in this study of 10 patients with constitutional mismatch repair deficiency syndrome (CMMRD) suggests that developmental venous anomalies may be a characteristic of this syndrome that has not been
Ben-Sira, L   +7 more
core   +1 more source

No Overt Clinical Immunodeficiency Despite Immune Biological Abnormalities in Patients With Constitutional Mismatch Repair Deficiency

open access: yesFrontiers in Immunology, 2018
Immunoglobulin class-switch recombination (CSR) and somatic hypermutations (SHMs) are prerequisites for antibody and immunoglobulin receptor maturation and adaptive immune diversity.
Victoria K. Tesch   +25 more
doaj   +1 more source

Patient Safety and Organisational Accountability: Reassessing Criminal Liability Frameworks in Healthcare

open access: yesThe Modern Law Review, EarlyView.
Serious harm in healthcare often results from systemic failures, yet criminal accountability remains largely addressed through homicide law, gross negligence manslaughter and health‐and‐safety offences, frameworks that emphasise individual culpability and are ill‐suited to addressing organisational failings.
Sarah Bennett, Amel Alghrani
wiley   +1 more source

Aligning Transnational due Diligence: The EU Deforestation Regulation and Brazil's Fragmented Beef Governance

open access: yesGlobal Policy, EarlyView.
ABSTRACT Transnational due diligence regulations, such as the European Union Regulation on Deforestation‐Free Products (EUDR), are reshaping sustainability governance by transforming voluntary norms into binding global rules. Yet, their effectiveness depends on how well they align with domestic governance systems and on the power asymmetries that ...
John James Loomis   +2 more
wiley   +1 more source

A novel mouse model of PMS2 founder mutation that causes mismatch repair defect due to aberrant splicing

open access: yesCell Death and Disease, 2021
Hereditary non-polyposis colorectal cancer, now known as Lynch syndrome (LS) is one of the most common cancer predisposition syndromes and is caused by germline pathogenic variants (GPVs) in DNA mismatch repair (MMR) genes.
Kajal Biswas   +18 more
doaj   +1 more source

The law of AI knowledge distillation

open access: yesAmerican Business Law Journal, EarlyView.
Abstract Knowledge distillation—the practice of training a compact student model on the outputs of a larger teacher model—has emerged as the fastest‐growing technique for replicating and disseminating frontier artificial intelligence (AI) capabilities.
Taorui Guan
wiley   +1 more source

Constitutional mismatch repair deficiency syndrome: Clues from the clinic, proof in the genes

open access: yesPediatric Hematology Oncology Journal
Background: Constitutional mismatch repair deficiency (CMMRD), a rare autosomal recessive cancer predisposition syndrome, is characterized by neurocutaneous stigmata and early-onset aggressive multisystem malignancies.
Gnanamani Senguttuvan   +6 more
doaj   +1 more source

Partisan bias in a sorted party system: A problem of epistemic inequality

open access: yesAmerican Journal of Political Science, EarlyView.
Abstract Normative and empirical scholars typically treat partisans’ distrust of their political rivals as a product of individual cognitive biases. But even if bias is inevitable, it is parties’ coalition‐building and messaging strategies that determine who bias is directed toward.
Justin Pottle
wiley   +1 more source

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