Results 131 to 140 of about 45,599 (229)
Regulation of human CYP2C9 expression by electrophilic stress involves AP-1 activation and DNA looping [PDF]
, 2014 CYP2C9 and CYP2C19 are important human enzymes that metabolize therapeutic drugs, environmental chemicals and physiologically important endogenous compounds.
Goldstein, J. A. +4 more
core +1 more source
Journal of Pharmacy & Pharmaceutical Sciences, 2012 Purpose. Intestinal ischemia-reperfusion (I/R) damages remote organs, including the liver, and promotes multi-organ failure (MOF). However, the molecular mechanisms underlying acute liver injury after intestinal I/R have not been completely elucidated ...
Jiro Ogura +13 more
doaj +1 more source
Studies on Regioselective Binding Mode of Steroid Molecules in Homology Modeled Cytochrome P450-2C11 [PDF]
, 2009 In this study, we investigated the regioselective binding mode of steroid molecules and structure requirements for steroid molecules for 16[alpha]-hydroxylation by Cytochrome P450-2C11.
Eiichi Akaho +3 more
core +1 more source
Drug Metabolism And Disposition, 2019 Environmental toxicants such as heavy metals from contaminated water or soil and isothiocyanates (ITC) from dietary sources act as pro-oxidants by directly generating reactive oxygen species (ROS) or through depleting cellular antioxidants such as ...
M. Paszek, R. Tukey
semanticscholar +1 more source
Effect of FSH on testicular morphology and spermatogenesis in gonadotrophin-deficient hypogonadal mice lacking androgen receptors [PDF]
, 2010 Follicle stimulating hormone (FSH) and androgen act to stimulate and maintain spermatogenesis. FSH acts directly on the Sertoli cells to stimulate germ cell number and acts indirectly to increase androgen production by the Leydig cells.
Abel, M.H. +4 more
core +2 more sources
Journal of Pharmacology and Experimental Therapeutics, 2019 Adenosine deaminases acting on RNA (ADARs) enzymes-catalyzing adenosine-to-inosine RNA editing possibly modulates gene expression and function. In this study, we investigated whether ADARs regulate the expression of human constitutive androstane receptor
Masataka Nakano, T. Fukami, M. Nakajima
semanticscholar +1 more source
Xenobiotica; the fate of foreign compounds in biological systems, 2019 Cytochrome P450, which is expressed in humans and other animals, is a superfamily of drug-metabolizing enzymes that play important roles in the metabolism of endogenous and xenobiotic substrates via oxidation, peroxidation and reduction.
Lixia Xie +6 more
semanticscholar +1 more source
Allyl sulfur compounds and cellular detoxification system: effects and perspectives in cancer therapy [PDF]
, 2011 Natural organosulfur compounds (OSCs) have been shown to have chemopreventive effects and to suppress the proliferation of tumor cells in vitro through the induction of apoptosis.
Melino, S, Paci, M, Sabelli, R
core +1 more source
, 2014 Hormonal homeostasis is essential for a variety of physiological and pathological processes. Elimination and detoxification of xenobiotics, such as drugs introduced into the human body, could disrupt the balance of hormones due to the induction of drug ...
Dai, Shu +4 more
core
Scientific Reports, 2019 Bisphenol A (BPA) is used as an industrial raw material for polycarbonate plastics and epoxy resins; however, various concerns have been reported regarding its status as an endocrine-disrupting chemical.
Takahiro Masuya +3 more
doaj +1 more source