Results 131 to 140 of about 69,599 (292)

Calibrating evanescent-wave penetration depths for biological TIRF microscopy [PDF]

, 2019
Roughly half of a cells proteins are located at or near the plasma membrane. In this restricted space the cell senses its environment, signals to its neighbors and ex-changes cargo through exo- and endocytotic mechanisms. Ligands bind to receptors, ions flow across channel pores, and transmitters and metabolites are transported against con-centration ...
arxiv   +1 more source

Cytochrome P450 2B6 (CYP2B6) and constitutive androstane receptor (CAR) polymorphisms are associated with early discontinuation of efavirenz-containing regimens [PDF]

, 2017
Objectives Cytochrome P450 2B6 (CYP2B6) is responsible for the metabolic clearance of efavirenz and single nucleotide polymorphisms (SNPs) in the CYP2B6 gene are associated with efavirenz pharmacokinetics. Since the constitutive androstane receptor (CAR)
Back, David J., Baumgarten, Axel, Becker, Werner, Bieniek, Bernhard, Bogner, Johannes R., Brockmeyer, Norbert, Brockmeyer, Norbert H., Buhk, Thomas, Carganico, Andreas, Dlugay, Verena, Dupke, Stephan, Egan, Deirdre, Esser, Stefan, Esser, Stefan, Fenske, Stefan, Freiwald, Matthias, Frietsch, Bernhard, Fätkenheuer, Gerd, Gölz, Jörg, Harrer, Thomas, Harrer, Thomas, Hartl, Helmut, Hendra, Heidy, Hoffmann, Christian, Hower, Martin, Jaegel-Guedes, Eva, Jaeger, Hans, Jaeger, Hans, Jetter, Alexander, Klinker, Hartwig, Knechten, Heribert, Koeppe, Siegfried, Kreckel, Peter, Kuhlmann, Birger, Lauenroth-Mai, Elke, Michalik, Claudia, Moll, Arend, Mosthaf, Franz, Mutz, Antonius, Müller, Markus, Owen, Andrew, Platten, Martin, Plettenberg, Andreas, Rausch, Michael, Reuter, Stefan, Rieke, Ansgar, Rockstroh, Juergen, Schlote, Frank, Schmidt, Reinhold, Scholten, Stefan, Schuler, Christoph, Siccardi, Marco, Skaletz-Rorowski, Adriane, Staszewski, Schlomo, Stellbrink, Hans-Jürgen, Stoehr, Albrecht, Ulmer, Albrecht, Volkert, Ramona, Wyen, Christoph, Zeitz, Martin   +59 more
core  

Modulation of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) by 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives, ligands of peripheral benzodiazepine receptor (PBR) [PDF]

, 2010
Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) regulate xenobiotic sensing and metabolism through interactions with multiple exogenous and endogenous chemicals.
Anderson, Linnea E., Dring, Ann M., Hamel, Laura D., Stoner, Matthew A.   +3 more
core   +2 more sources

Contradictory Role of Gadd45β in Liver Diseases

Journal of Cellular and Molecular Medicine, Volume 28, Issue 23, December 2024.
ABSTRACT There are three homologous proteins (α, β and γ) in the growth arrest and DNA damage 45 (Gadd45) family. These proteins act as cellular responders to physiological and environmental stimuli. Gadd45β plays a significant role in the pathogenesis of liver diseases. Liver injury and growth stimulation increase expression of Gadd45β, which promotes
Chi Wu, Xiaozhen Song, Miaoxin Zhang, Longjun Yang, Panpan Lu, Qiang Ding, Mei Liu   +6 more
wiley   +1 more source

The Nrf2 Activator Oltipraz Also Activates the Constitutive Androstane Receptor [PDF]

Drug Metabolism and Disposition, 2008
Oltipraz (OPZ) is a well known inducer of NAD(P)H:quinone oxidoreductase (NQO1) along with other enzymes that comprise the nuclear factor E2-related factor 2 (Nrf2) battery of detoxification genes. However, OPZ treatment also induces expression of CYP2B, a gene regulated by the constitutive androstane receptor (CAR).
Angela L. Slitt, Wendong Huang, Youcai Zhang, David D. Moore, Lisa M. Augustine, Curtis D. Klaassen, Nathan J. Cherrington, Craig D. Fisher, Jonathan M. Maher, Jonathan P. Jackson, Matthew D. Merrell   +10 more
openaire   +3 more sources

Constitutive androstane receptor induced-hepatomegaly and liver regeneration is partially via yes-associated protein activation

Acta Pharmaceutica Sinica B, 2021
The constitutive androstane receptor (CAR, NR3I1) belongs to nuclear receptor superfamily. It was reported that CAR agonist TCPOBOP induces hepatomegaly but the underlying mechanism remains largely unknown.
Yue Gao, Shicheng Fan, Hua Li, Yiming Jiang, Xinpeng Yao, Shuguang Zhu, Xiao Yang, Ruimin Wang, Jianing Tian, Frank J. Gonzalez, Min Huang, Huichang Bi   +11 more
doaj  

Cytochrome P450 Induction and Xeno‐Sensing Receptors Pregnane X Receptor, Constitutive Androstane Receptor, Aryl Hydrocarbon Receptor and Peroxisome Proliferator‐Activated Receptor &agr; at the Crossroads of Toxicokinetics and Toxicodynamics

Basic & Clinical Pharmacology & Toxicology, 2018
Pregnane X receptor (PXR), constitutive androstane receptor (CAR), aryl hydrocarbon receptor (AHR) and peroxisome proliferator-activated receptor α (PPARα) are ligand-activated transcription factors that regulate expression of many xenobiotic ...
J. Hakkola, C. Bernasconi, S. Coecke, L. Richert, T. Andersson, O. Pelkonen   +5 more
semanticscholar   +1 more source

Nuclear receptors in vascular biology [PDF]

, 2015
Nuclear receptors sense a wide range of steroids and hormones (estrogens, progesterone, androgens, glucocorticoid, and mineralocorticoid), vitamins (A and D), lipid metabolites, carbohydrates, and xenobiotics.
A Chawla, A McCurley, AA Hamers, AL Bookout, B Fisslthaler, BG Hoebel, C McCarthy, C Zhou, CH Lee, CK Glass, CK Huang, CT Lee, D Bishop-Bailey, D Bishop-Bailey, David Bishop-Bailey, DP Edwards, E Gerlach, F Akbiyik, FA Pereira, FL Wynne, FY Ali, G Pascual, I Dussault, I Spoletini, J He, J Qin, J Sonoda, J Xiang, K Spruiell, KE Swales, L Calza, L Li, L Piqueras, LA Moraes, LA Moraes, LJ Jonk, LR You, M Kaushik, M Matic, N Albermann, N Schafer, N Takamoto, Q Qin, R Zhao, S Asgary, S Chakrabarti, S Marino De, S Stein, SA Kliewer, V Zoete, W El-Sankary, WC Lau, X Wang, Y Ma, Y Sui, Y Sui, YW Hu   +56 more
core   +2 more sources

Activation of Constitutive Androstane Receptor Prevents Cholesterol Gallstone Formation [PDF]

The American Journal of Pathology, 2017
Cholesterol gallstone disease (CGD) is one of the most common gastrointestinal diseases. Lithogenic hepatic bile secretion precedes the formation of cholesterol gallstones. Constitutive androstane receptor (CAR), a member of nuclear family, plays an important role in cholesterol and bile acid metabolism. To examine whether activation of CAR can prevent
Jing Shen, Qinhui Liu, Jiangying Kuang, Shiyun Pu, Tong Wu, Hong Li, Shihai Cheng, Yanping Li, Wei Jiang, Zhiyong Zhang, Rui Li, Min Zou, Lei Chen, Jinhan He   +13 more
openaire   +3 more sources

Regulation of biotransformation systems and ABC transporters by Benznidazole in HepG2 cells: involvement of Pregnane X-Receptor [PDF]

, 2012
Background: Benznidazole (BZL) is the only antichagasic drug available in most endemic countries. Its effect on the expression and activity of drug-metabolizing and transporter proteins has not been studied yet.
Arias, Agostina, Catania, Viviana Alicia, Luquita, Marcelo Gabriel, Mottino, Aldo Domingo, Perdomo, Virginia, Rigalli, Juan Pablo, Ruiz, Maria Laura, Theile, Dirk, Villanueva, Silvina Stella Maris, Weiss, Johanna   +9 more
core   +2 more sources