Results 81 to 90 of about 2,179,886 (275)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

First results from a parametrized Fixed-Point QCD action

, 2001
We have constructed a new fermion action which is an approximation to the (chirally symmetric) Fixed-Point action, containing the full Clifford algebra with couplings inside a hypercube and paths built from renormalization group inspired fat links.
DeGrand, DeGrand, F. Niedermayer, Gattringer, Ginsparg, Hasenfratz, Hasenfratz, Hasenfratz, K. Holland, Kaplan, Lüscher, Narayanan, Narayanan, Niedermayer, Niedermayer, P. Hasenfratz, S. Hauswirth, Shamir, T. Jörg   +18 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

A covariantisation of M5-brane action in dual formulation

Journal of High Energy Physics, 2018
We construct a manifestly diffeomorphic M5-brane action in dual formulation coupled to an eleven-dimensional supergravity target space. The covariantisation is carried out by using (generalised) PST technique with 5 auxiliary scalar fields, which are ...
Sheng-Lan Ko, Pichet Vanichchapongjaroen
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Reflexivity and Narratives in Action Research: A Discursive Approach

Forum: Qualitative Social Research, 2003
The paper offers an analysis of how narratives may be reflexively used at different stages of the research process as a tool to access the interpretative frameworks that actors use to construct their accounts of events and to make sense of their action ...
Monica Colombo
doaj  

Highest weight representations of the quantum algebra U_h(gl_\infty)

, 1997
A class of highest weight irreducible representations of the quantum algebra U_h(gl_\infty) is constructed. Within each module a basis is introduced and the transformation relations of the basis under the action of the Chevalley generators are explicitly
Date E, Date E, Drinfeld V, Feigin B, Goddard P, Kac V G, Kac V G, Kac V G, Levendorskii S, N I Stoilova, Palev T D, Palev T D, Palev T D, T D Palev   +13 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Low-energy effective action in 5D,N=2 supersymmetric gauge theory

Nuclear Physics B, 2019
We construct N=2 supersymmetric low-energy effective action of 5D,N=2 supersymmetric Yang–Mills (SYM) theory in 5D,N=1 harmonic superspace. It is obtained as a hypermultiplet completion of the leading Wln⁡W-term in the N=1 SYM low-energy effective action
I.L. Buchbinder, E.A. Ivanov, I.B. Samsonov   +2 more
doaj   +1 more source