Results 71 to 80 of about 387,910 (265)

Passion to practice: Early career teachers’ motivation, content confidence, and coping strategies in teaching

Interdisciplinary Journal of Education Research
This study examines how early career teachers (ECTs) in South African schools perceive their readiness to teach, focusing on intrinsic motivation, perceived gaps in content knowledge, coping strategies, and the development of emerging confidence ...
Anthony Mpisi, Nyarayi Chinyama
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Assessing Teachers’ Technological, Pedagogical, and Content Knowledge

, 2017
TPACK, originally conceived by Mishra and Koehler (2006), was developed as a framework to better understand the knowledge and competencies required for teachers to effectively integrate technology in the classroom (Koehler & Mishra, 2009; Koh, Chai ...
Walker, Reshid Xavier.
core   +1 more source

Reading and the Profession: On the Literary Education of English School Teachers

Acta Didactica Norge, 2018
The article addresses the question of how English departments best can teach literature and literary reading to future upper secondary school teachers of English.
Katherina Dodou
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

De uitdaging van grootschalige stelsel voor ketencommunicatie : over de betekenis van het vakgebied 'Keteninformatisering in de rechtstaat'

, 2011
Wij leiden vooral op in kleinschalig rationeel denken, of het nu wiskunde, informatiekunde, geneeskunde of rechtswetenschappen betreft. Grootschalige stelsels plaatsen ons daarom in de praktijk voor moeilijke uitdagingen, omdat onze -op rationele ...
Sub Content & Knowledge Engineering begr, Grijpink, Jan, Content and Knowledge Engineering, Grijpink, J.H.A.M.   +3 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

PERSPECTIVES OF EFL TEACHERS ON CONTENT KNOWLEDGE, TECHNOLOGICAL CONTENT KNOWLEDGE, AND PEDAGOGICAL CONTENT KNOWLEDGE

European Journal of English Language Teaching
A qualitative study was conducted in a Vietnamese city to investigate the EFL teachers’ perspectives on CK, TCK, and PCK. Qualitative data revealed that integrating Technological Pedagogical Content Knowledge (TPACK) into English teaching practices is considered time-consuming, impeded by factors such as time constraints and students' cognitive ...
openaire   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source