Results 1 to 10 of about 415,152 (263)

Long noncoding RNAs and metabolic memory associated with continued progression of diabetic retinopathy [PDF]

Journal of Diabetes
Progression of diabetic retinopathy resists arrest even after institution of intensive glycemic control, suggesting a “metabolic memory” phenomenon, but the mechanism responsible for this phenomenon is still elusive.
Jay Kumar, Pooja Malaviya, Renu A. Kowluru   +2 more
doaj   +2 more sources

Prolonged exposure to cocaine self-administration results in a continued progression of alterations in functional activity in a nonhuman primate model [PDF]

Drug and Alcohol Dependence Reports, 2023
Background: Studies of nonhuman primates with exposures of up to 100 days of cocaine self-administration (SA) have provided evidence that the central effects of cocaine progress over time. These durations of cocaine exposure, however, may be insufficient
Linda J. Porrino, Hilary R. Smith, Thomas J.R. Beveridge, Mack D. Miller, Susan H. Nader, Michael A. Nader   +5 more
doaj   +2 more sources

Two case reports of continued progression of chronic ocular graft-versus-host disease without concurrent systemic comorbidities treated by amniotic membrane transplantation [PDF]

BMC Ophthalmology, 2021
Background Chronic ocular graft-versus-host disease (oGVHD) is an ocular comorbidity of graft-versus-host disease (GVHD) that usually occurs concurrently with systemic manifestations.
Hideto Ikarashi, Naohiko Aketa, Eisuke Shimizu, Yoji Takano, Tetsuya Kawakita, Yuichi Uchino, Yukihiro Matsumoto, Junko Ogawa, Kazuo Tsubota, Yoko Ogawa   +9 more
doaj   +2 more sources

Chemoradiotherapy followed by continued immunotherapy for out-of-field progression during consolidation in limited-stage SCLC: a case report

Frontiers in Immunology
BackgroundWhile consolidation immunotherapy after chemoradiotherapy (CRT) improves survival in limited-stage small cell lung cancer (LS-SCLC), some patients develop out-of-field progression during consolidation.
Ying Jiang, Xu Tong, Nan Bi
doaj   +3 more sources

Role of progression of training volume on intramuscular adaptations in patients with chronic obstructive pulmonary disease

Frontiers in Physiology, 2022
Introduction: Quadriceps dysfunction is a common systemic manifestation of chronic obstructive pulmonary disease (COPD), for which treatment using resistance training is highly recommended. Even though training volume is suggested to be a key explanatory
Andre Nyberg, Andre Nyberg, Nadia Milad, Mickael Martin, Dany Patoine, Mathieu C Morissette, Didier Saey, François Maltais   +7 more
doaj   +1 more source

Progression Patterns, Treatment, and Prognosis Beyond Resistance of Responders to Immunotherapy in Advanced Non-Small Cell Lung Cancer

Frontiers in Oncology, 2021
IntroductionImmune checkpoint inhibitors (ICIs) have changed the management of non-small cell lung cancer (NSCLC). However, resistance is inevitable.
Yanjun Xu, Hui Li, Yun Fan
doaj   +1 more source

Impact of the treatment crossover design on comparative efficacy in EMPOWER-Lung 1: Cemiplimab monotherapy as first-line treatment of advanced non-small cell lung cancer

Frontiers in Oncology, 2023
ObjectivesIn randomized-controlled crossover design trials, overall survival (OS) treatment effect estimates are often confounded by the control group benefiting from treatment received post-progression.
Josephine Louella Feliciano, Dylan McLoone, Yingxin Xu, Ruben G.W. Quek, Andreas Kuznik, Jean-Francois Pouliot, Giuseppe Gullo, Petra Rietschel, Patricia Guyot, Gerasimos Konidaris, Keith Chan, Sam Keeping, Florence R. Wilson, Nick Freemantle   +13 more
doaj   +1 more source

Epikeratophakia for Keratoconus: A Case Report with 30 Years of Follow-Up

Case Reports in Ophthalmological Medicine, 2023
Background. Epikeratophakia is a refractive surgical procedure used to correct aphakic eyes, hyperopia, and keratoconus and is often performed in children.
Takashi Miyai, Tetsuya Toyono, Hitoha Ishii, Kohdai Kitamoto, Yukako Taketani, Takashi Ono, Makoto Aihara, Kazunori Miyata   +7 more
doaj   +1 more source

Formação por ciclos Formation by cycles

Educar em Revista, 2006
Artigo desenvolvido a partir dos estudos de Mestrado na Universidade Federal do Paraná, na linha de pesquisa Currículo, Conhecimento e Saberes nas Práticas Escolares, investigando a Formação por Ciclos.
Lidia Nedbajluk
doaj   +1 more source

Avaliação e progressão continuada: o que a realidade desvela Evaluation and continued progression: what reality unveils

Pro-Posições, 2010
Este artigo aborda a compreensão da avaliação no interior da implantação do Regime de Progressão Continuada no Estado de São Paulo. Ao penetrar nos intrincados caminhos da realidade escolar, por meio da pesquisa qualitativa, acompanharam-se ...
Regiane Helena Bertagna
doaj   +1 more source