Results 21 to 30 of about 2,095,269 (256)

Mitochondrial Dynamics in the Metabolic Memory of Diabetic Retinopathy

Journal of Diabetes Research, 2022
Mitochondria play a central role in the development of diabetic retinopathy and in the metabolic memory associated with its continued progression. Mitochondria have a regulated fusion fission process, which is essential for their homeostasis.
Ghulam Mohammad, Renu A. Kowluru
doaj   +1 more source

Continued gefitinib retreatment beyond progression in patients with advanced non-small cell lung cancer harboring sensitive mutations

Journal of International Medical Research, 2020
Purpose To evaluate the effectiveness and safety of gefitinib retreatment beyond disease progression in patients with advanced non-small cell lung cancer (NSCLC) with sensitive epidermal growth factor receptor ( EGFR ) mutations.
Xuhong Jiang, Xiaoqing Li, Lingli Tu, Jin Cai, Man Wei, Zhongjun Wu, Lan Sun   +6 more
doaj   +1 more source

Intermittent induction of HIF-1α produces lasting effects on malignant progression independent of its continued expression.

PLoS ONE, 2015
Dysregulation of hypoxia-inducible transcription factors HIF-1α and HIF-2α correlates with poor prognosis in human cancers; yet, divergent and sometimes opposing activities of these factors in cancer biology have been observed.
Hyunsung Choi, David L Gillespie, Shauna Berg, Christopher Rice, Sandrine Couldwell, Jie Gu, Howard Colman, Randy L Jensen, L Eric Huang   +8 more
doaj   +1 more source

Progression of comorbidities in youth with overweight or obesity during the COVID-19 pandemic

BMC Pediatrics, 2023
Background Childhood obesity rates have continued to increase with the COVID-19 pandemic. However, data are limited on the impact of increasing obesity on associated comorbidities. Methods We evaluated the progression of overweight- or obesity-associated
Erica Wee, Ashley K. Sherman, Safa Farrukh, Mark A. Clements, Kelsee Halpin, Yun Yan   +5 more
doaj   +1 more source

Progression-free survival according to MTV.

, 2022
Progression-free survival according to MTV.
Nina Jehanno (11949663), Pierre Payoux (3484706), Daniel Orbach (11949669), Marie-Pierre Castex (11949666), Thomas Mognetti (582844), Corradini Nadège (11949672), Helio Fayolle (11949660), Anne Hitzel (11949675), Valerie Lauwers-Cances (437048)   +8 more
core   +1 more source

Educar sem reprovar: desafio de uma escola para todos Educating without failing: a challenge to a school for everyone

Educação e Pesquisa, 2009
Neste artigo, discute-se a realização do direito à educação e a forma de organização do ensino na perspectiva de democratizá-la. Tem-se como pressuposto que os ciclos e a progressão continuada podem ser uma forma de organização do ensino que favorece a ...
Márcia Aparecida Jacomini
doaj   +1 more source

Risk factors and clinical outcomes of systemic cancer treatment delays in Filipino patients with solid tumor malignancy during the COVID‐19 pandemic: A single tertiary center study

Cancer Reports, 2022
Background Cancer care during the Covid‐19 pandemic has been challenging especially in a developing country such as the Philippines. Oncologists were advised to prioritize chemotherapy based on the absolute benefit that the patient may receive, which ...
Jessa Gilda Pandy, Omar Maaño, Joanmarie C. Balolong‐Garcia, Jay T. Y. Datukan   +3 more
doaj   +1 more source

Treatment Choice for Advanced Non-small Cell Lung Cancer Patients Who Had Gradual Progression After EGFR-TKIs: 32 Cases Report

Chinese Journal of Lung Cancer, 2013
Background and objective The epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have been widely used in the treatment of the advanced non-small cell lung cancer (NSCLC), especially in the adenocarcinoma patients with activating EGFR
Lin LIN, Bin WANG, Xuezhi HAO, Puyuan XING, Junling LI, Xiangru ZHANG, Yuankai SHI   +6 more
doaj   +1 more source

Reduction of pericardial effusion in advanced non-small cell lung cancer patients with KRAS, TP53, and MET mutation treated with nivolumab

Journal of International Medical Research, 2020
Nivolumab is an immune checkpoint inhibitor that is used to treat various advanced cancers, including metastatic non-small cell lung cancer (NSCLC). Nivolumab treatment has different side effects.
Zhihui Cai, Yuan Yao
doaj   +1 more source

A Phase 2 Study of Camrelizumab for Advanced Hepatocellular Carcinoma: Two-Year Outcomes and Continued Treatment beyond First RECIST-Defined Progression

Liver Cancer, 2021
Introduction: In a multicenter, open-label, parallel-group, randomized, phase 2 study for pretreated advanced hepatocellular carcinoma (HCC), camrelizumab showed potent antitumor activity and acceptable safety profile.
Zhenggang Ren, Shukui Qin, Zhiqiang Meng, Zhendong Chen, Xiaoli Chai, Jianping Xiong, Yuxian Bai, Lin Yang, Hong Zhu, Weijia Fang, Xiaoyan Lin, Xiaoming Chen, Enxiao Li, Linna Wang, Ping Yan, Jianjun Zou   +15 more
doaj   +1 more source