Results 21 to 30 of about 1,053,987 (300)

The role of stereotactic body radiation therapy in oligometastatic colorectal cancer [PDF]

, 2017
Rationale: Regorafenib is the new standard third-line therapy in metastatic colorectal cancer (mCRC). However, the reported 1-year overall survival rate does not exceed 25%.
Archibugi, Livia, Botticelli, Andrea, Castaldi, Nadia, Falcone, Rosa, Marchetti, Paolo, Mazzuca, Federica, Osti, Mattia Falchetto, Roberto, Michela   +7 more
core   +1 more source

Mitochondrial Dynamics in the Metabolic Memory of Diabetic Retinopathy

Journal of Diabetes Research, 2022
Mitochondria play a central role in the development of diabetic retinopathy and in the metabolic memory associated with its continued progression. Mitochondria have a regulated fusion fission process, which is essential for their homeostasis.
Ghulam Mohammad, Renu A. Kowluru
doaj   +1 more source

Therapeutic approaches with intravitreal injections in geographic atrophy secondary to age-related macular degeneration: current drugs and potential molecules [PDF]

, 2019
The present review focuses on recent clinical trials that analyze the efficacy of intravitreal therapeutic agents for the treatment of dry age-related macular degeneration (AMD), such as neuroprotective drugs, and complement inhibitors, also called ...
Cerini, Alberto, Greco A., La Cava M, Lambiase A, Limoli PG, Nebbioso M   +5 more
core   +1 more source

A progressão continuada no estado de São Paulo: considerações a partir da perspectiva de educadores

Psicologia Escolar e Educacional
Este estudo analisou a Progressão Continuada na perspectiva de educadores do ensino fundamental. O método utilizado foi a realização de redações e grupos de reflexão visando conhecer como os educadores compreendem a política educacional, como a ...
Lygia de Sousa Viégas, Marilene Proença Rebello de Souza   +1 more
doaj   +3 more sources

Continued gefitinib retreatment beyond progression in patients with advanced non-small cell lung cancer harboring sensitive mutations

Journal of International Medical Research, 2020
Purpose To evaluate the effectiveness and safety of gefitinib retreatment beyond disease progression in patients with advanced non-small cell lung cancer (NSCLC) with sensitive epidermal growth factor receptor ( EGFR ) mutations.
Xuhong Jiang, Xiaoqing Li, Lingli Tu, Jin Cai, Man Wei, Zhongjun Wu, Lan Sun   +6 more
doaj   +1 more source

Resurgence of HIV infection among men who have sex with men in Switzerland : mathematical modelling study [PDF]

, 2012
New HIV infections in men who have sex with men (MSM) have increased in Switzerland since 2000 despite combination antiretroviral therapy (cART). The objectives of this mathematical modelling study were: to describe the dynamics of the HIV epidemic in ...
Bezemer, Daniela, Bucher, Heiner C., de Wolf, Frank, Derendinger, Steven, Fraser, Christophe, Gebhardt, Martin, Glass, Tracy R., Jeannin, André, Low, Nicola, Swiss HIV, Cohort Study, van Sighem, Ard, Vernazza, Pietro, Vidondo, Beatriz   +12 more
core   +5 more sources

Targeting interleukin-1β protects from aortic aneurysms induced by disrupted transforming growth factor β signaling [PDF]

, 2017
Aortic aneurysms are life-threatening conditions with effective treatments mainly limited to emergency surgery or trans-arterial endovascular stent grafts, thus calling for the identification of specific molecular targets.
Bizzotto, Dario, Braghetta, Paola, Bressan, Giorgio M., Carnevale, Daniela, Carnevale, Lorenzo, Carnevale, Raimondo, Casaburo, Manuel, Cifelli, Giuseppe, DA ROS, Francesco, Fardella, Stefania, Iacobucci, Roberta, Lembo, Giuseppe, Perrotta, Marialuisa, Vinciguerra, Iolanda   +13 more
core   +1 more source

Intermittent induction of HIF-1α produces lasting effects on malignant progression independent of its continued expression.

PLoS ONE, 2015
Dysregulation of hypoxia-inducible transcription factors HIF-1α and HIF-2α correlates with poor prognosis in human cancers; yet, divergent and sometimes opposing activities of these factors in cancer biology have been observed.
Hyunsung Choi, David L Gillespie, Shauna Berg, Christopher Rice, Sandrine Couldwell, Jie Gu, Howard Colman, Randy L Jensen, L Eric Huang   +8 more
doaj   +1 more source

On transfer operators for continued fractions with restricted digits [PDF]

, 2001
For any non-empty subset I of the natural numbers, let {Lambda}I denote those numbers in the unit interval whose continued fraction digits all lie in I. Define the corresponding transfer operator Formula.
Gonzalez, Luis Felipe, Jenkinson, Oliver, Urba'nski, Mariusz   +2 more
core   +3 more sources

Progression of comorbidities in youth with overweight or obesity during the COVID-19 pandemic

BMC Pediatrics, 2023
Background Childhood obesity rates have continued to increase with the COVID-19 pandemic. However, data are limited on the impact of increasing obesity on associated comorbidities. Methods We evaluated the progression of overweight- or obesity-associated
Erica Wee, Ashley K. Sherman, Safa Farrukh, Mark A. Clements, Kelsee Halpin, Yun Yan   +5 more
doaj   +1 more source