Results 81 to 90 of about 1,053,987 (300)

Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND). a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension [PDF]

, 2018
Background: Although several disease-modifying treatments are available for relapsing multiple sclerosis, treatment effects have been more modest in progressive multiple sclerosis and have been observed particularly in actively relapsing subgroups or ...
Achiron, Anat, Airas, Laura, Al Khedr, Abdullatif, Alvarez Cermeño, Jose Carlos, Arnold, Douglas L, Ayuso, Guillermo Izquierdo, Bandari, Daniel, Bartholomé, Emmanuel, Baum, Karl, Bergamaschi, Roberto, Berger, Joseph, Berthele, Achim, Bhan, Virender, Blevins, Gregg, Boyko, Alexey, Brassat, David, Brochet, Bruno, Brunet, Donald, Cadavid, Diego, Camac, Ann, Campbell, Nolan, Camu, William, Chang, Ih, Chefranova, Zanna, Cohan, Stanley, Comi, Giancarlo, Conway, Jill, Cottone, Salvatore, Czarnecki, Maciej, D'Hooghe, Marie, Debouverie, Marc, Devonshire, Virginia, Deykin, Aaron, Drozdowski, Wieslaw, Duddy, Martin, Dufek, Michal, Duquette, Pierre, Edwards, Keith, Elovaara, Irina, Eralinna, Juha-Pekka, Escartin, Antonio, Evdoshenko, Evgeny, Fabian, Michelle, Faiss, Juergen, Fernandez, Oscar Fernandez, Flachenecker, Peter, Florin, Jack, Forrestal, Fiona, Frederiksen, Jette, Freedman, Mark, Freedman, Mark S, Freedman, Steven, Frequin, Stephan, Fryze, Waldemar, Gairin, Xavier Montalban, Garcia-Merino, Antonio, Garwacki, Dennis, Goldman, Myla, Goldman, Myla D, Gran, Bruno, Grand'Maison, François, Grimaldi, Luigi, Gunnarsson, Martin, Hardiman, Orla, Harrison, Daniel, Harrower, Timothy, Hartung, Hans-Peter, Havrdová, Eva Kubala, Havrdová, Eva Kubala, Hernandez Perez, Miguel Angel, Herrman, Craig, Hertmanowska, Hanka, Ho, Pei-Ran, Hobart, Jeremy, Hohlfeld, Reinhard, Huang, Deren, Hupperts, Raymond, Ilkowski, Jan, Jacques, François, Javed, Adil, Jeffery, Douglas, Jeffery, Douglas, Kamin, Stephen, Kaminska, Anna, Kanovsky, Petr, Kant, Matthias, Kapoor, Raju, Kapoor, Raju, Karussis, Dimitrios, Katsamakis, George, Khabirov, Farit, Khatri, Bhupendra, Killestein, Joep, Klodowska-Duda, Gabriela, Krumbholz, Markus, Lallana, José Meca, Langer-Gould, Annette, Lapierre, Yves, Laplaud, David, Lassek, Christoph, Lebrun Frenay, Christine, Lee, Liesly, Lee, Martin, Lucas, Nisha, Lycke, Jan, Lynch, Sharon, Maciejowski, Maciej, Maeurer, Mathias, Mancardi, Giovanni Luigi, Martin, Claes, Massacesi, Luca, Mattison, Paul, Mattson, David, Mcguigan, Christopher, Meuth, Sven, Mikol, Dan, Miller, Aaron, Miller, Tamara, Miravalle, Augusto, Morra, Vincenzo Brescia, Morrow, Sarah, Moses, Harold, Motta, Ewa, Muley, Suraj, Napier, James, Nicholas, Richard, Nielsen, Allen, Nocentini, Ugo, Oreja-Guevara, Celia, Pachner, Andrew, Pandolfo, Massimo, Pardo, Gabriel, Pearson, Owen, Pelletier, Jean, Petersen, Thor, Picone, Maryann, Piehl, Fredrik, Podemski, Ryszard, Potemkowski, Andrzej, Rashid, Waqar, Ravnborg, Mads, Robertson, Derrick, Rog, David, Rog, Teresa, Roshanisefat, Homayoun, Royal, Walter, Saiz Hinarejos, Albert, Salvetti, Marco, Sarasoja, Taneli, Scarpini, Elio, Schrijver, Hans, Sellebjerg, Finn, Sellebjerg, Finn, Selmaj, Krzysztof, Sharrack, Basil, Sheppard, Christopher, Silber, Eli, Sivertseva, Stella, Sola, Patrizia, Steiner, Deborah, Stelmasiak, Zbigniew, Stepien, Adam, Stetkarova, Ivana, Sundstrom, Peter, Talabova, Marika, Tedeschi, Gioacchino, Thrower, Ben, Trojano, Maria, Turner, Ben, Tutaj, Andrzej, Twyman, Cary, Van Dijl, Ronald, van Munster, Erik, Van Wijmeersch, Bart, Vermersch, Patrick, Vukusi, Sandra, Waubant, Emmanuelle, Wendt, Jeanette, Williams, Anna, Woolmore, John, Yadav, Vijayshree, Yakupov, Eduard, Yeung, Michael, Young, Carolyn, Yu, Bei, Zabad, Rana, Zaborski, Jacek, Zaffaroni, Mauro, Zarelli, Greg, Ziemssen, Tjalf   +189 more
core   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Continuing a cancer treatment despite tumor growth may be valuable: sunitinib in renal cell carcinoma as example.

PLoS ONE, 2014
BackgroundThe US FDA and the EMA have approved seven agents for the treatment of renal cell carcinoma, primarily based on differences in progression-free survival (PFS).
Mauricio Burotto, Julia Wilkerson, Wilfred Stein, Robert Motzer, Susan Bates, Tito Fojo   +5 more
doaj   +1 more source

Noninvasive Urinary Monitoring of Progression in IgA Nephropathy. [PDF]

, 2019
Standard methods for detecting and monitoring of IgA nephropathy (IgAN) have conventionally required kidney biopsies or suffer from poor sensitivity and specificity.
Fervenza, Fernando C, Lafayette, Richard A, Sarwal, Minnie M, Sarwal, Reuben D, Yang, Joshua YC   +4 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Avelumab plus axitinib for translocation renal cell carcinoma: A case series and literature review

IJU Case Reports
Introduction Patients with translocation renal cell carcinoma (tRCC) have a poor prognosis without standardized treatment. Case presentation The first case was of a 72‐year‐old woman who underwent robot‐assisted partial nephrectomy for a left renal tumor
Kenta Takahashi, Renpei Kato, Daiki Ikarashi, Tomohiko Matsuura, Shigekatsu Maekawa, Mitsugu Kanehira, Ryo Takata, Jun Sugimura, Takaya Abe, Wataru Obara   +9 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source