Results 81 to 90 of about 422,013 (303)

Progress Continuance Sustainability

American Journal of Industrial and Business Management, 2015
The “progress” is the outcome of the intentional alteration of the wild surrounds to establish enhanced friendly life conditions for men. The swop entails the earth inhabitants, matching extant peoples by the “social breakthrough”, leading to “collective orders” or human civilization political endings.
MICHELINI DI SAN MARTINO, RINALDO, RAZZOLI, ROBERTO   +1 more
openaire   +4 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Mitochondrial Quality Control and Metabolic Memory Phenomenon Associated with Continued Progression of Diabetic Retinopathy. [PDF]

Int J Mol Sci, 2023
Kowluru RA, Alka K.
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Cohort childbearing age patterns in low-fertility countries in the late 20th century: Is the postponement of births an inherent element? [PDF]

Major changes in the age patterns of fertility were characteristic of fertility trends following the Second World War. The paper provides an overview and analysis of changes in age patterns of cohort childbearing in low-fertility countries during the ...
Tomas Frejka, Gérad Calot
core  

Continuation of targeted therapy after disease progression

, 2016
Kontynuacja leczenia pomimo progresji wydaje się na pierwszy rzut oka uzasadniona w przypadku leków celowanych, ukierunkowanych na ścieżki molekularne, od których guz nowotworowy jest uzależniony (oncogene addiction). Ilustracją tego zjawiska jest glivec
Nawrocki, Sergiusz
core   +2 more sources

Continuous immunotherapy beyond disease progression in patients with advanced non-small cell and small cell lung cancer

Cancer Immunology, Immunotherapy
Background The benefits of continuing immunotherapy beyond disease progression in advanced non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) remain uncertain, along with the specific patient subgroups that may gain the most from this ...
Jing Cheng, Wenwen Kang, Yueying Chen, Luyun Pan, Hedong Han, Tangfeng Lv   +5 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Impacts of the continued progression in the São Paulo state's education

, 2013
The presented article discuss theoretical context and the practical impact reported in the bibliography about Continued Progression at São Paulo State schools.
Cunha, Maira Darido da [UNESP], Pereira, Carlos Eduardo Candido [UNESP], Bizelli, Jose Luis [UNESP]   +2 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source