Results 61 to 70 of about 2,095,269 (256)

The Whole Picture of First-Line Osimertinib for EGFR Mutation-Positive Advanced NSCLC: Real-World Efficacy, Safety, Progression Pattern, and Posttreatment Therapy (Reiwa Study)

JTO Clinical and Research Reports
Introduction: Osimertinib is used as the first-line treatment for EGFR mutation-positive NSCLC. Nevertheless, its efficacy and safety in clinical practice remain to be fully elucidated and the pattern of progression and the optimal subsequent treatment ...
Kageaki Watanabe, MD, Yukio Hosomi, MD, PhD, Katsuhiko Naoki, MD, PhD, Yoshiro Nakahara, MD, PhD, Yoko Tsukita, MD, PhD, Hirotaka Matsumoto, MD, PhD, Kiyotaka Yoh, MD, Yasuhito Fujisaka, MD, PhD, Satoshi Takahashi, MD, PhD, Saori Takata, MD, PhD, Kazuhiro Usui, MD, PhD, Kazuma Kishi, MD, PhD, Go Naka, MD, PhD, Shu Tamano, MSS, Kohei Uemura, PhD, Hideo Kunitoh, MD, PhD   +15 more
doaj   +1 more source

Curious Continued Fractions, Nonlinear Recurrences and Transcendental Numbers [PDF]

, 2015
We consider a family of integer sequences generated by nonlinear recurrences of the second order, which have the curious property that the terms of the sequence, and integer multiples of the ratios of successive terms (which are also integers), appear ...
Hone, Andrew N.W.
core  

Progression-free survival for STS: multivariate analysis.

, 2017
Progression-free survival for STS: multivariate analysis.
Gualter Vaz (3715726), Olivier Collard (3715720), Dominique Ranchere-Vince (3715738), Pierre Meeus (3451424), Anne-Valérie Decouvelaere (346741), Eric De Laroche (3715729), Claire Cropet (3715732), Philippe Cassier (3451427), François-Noel Gilly (3715735), Pierre Etienne Heudel (3715741), Fadila Farsi (3715723), Isabelle Ray-Coquard (346757), Pierre Biron (3715714), Philippe Thiesse (804468), Jean-Yves Blay (72864), Olfa Derbel (3715717), Dominic Cellier (346755)   +16 more
core   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Second-line treatment patterns and outcomes in advanced HCC after progression on atezolizumab/bevacizumab

JHEP Reports
Background & Aims: Atezolizumab/bevacizumab (A/B) is now a standard first-line treatment for advanced hepatocellular carcinoma (HCC), but the optimal second-line regimen is not known.
Meng Wu, Claudia A.M. Fulgenzi, Antonio D’Alessio, Alessio Cortellini, Ciro Celsa, Giulia F. Manfredi, Bernardo Stefanini, Y. Linda Wu, Yi-Hsiang Huang, Anwaar Saeed, Angelo Pirozzi, Tiziana Pressiani, Lorenza Rimassa, Martin Schoenlein, Kornelius Schulze, Johann von Felden, Yehia Mohamed, Ahmed O. Kaseb, Arndt Vogel, Natascha Roehlen, Marianna Silletta, Naoshi Nishida, Masatoshi Kudo, Caterina Vivaldi, Lorenz Balcar, Bernhard Scheiner, Matthias Pinter, Amit G. Singal, Joshua Glover, Susanna Ulahannan, Fredrich Foerster, Arndt Weinmann, Peter R. Galle, Neehar D. Parikh, Wei-Fan Hsu, Alessandro Parisi, Hong Jae Chon, David J. Pinato, Celina Ang   +38 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Androgen receptor functions in prostate cancer development and progression

Asian Journal of Andrology, 2014
The androgen receptor (AR) is critical for the normal development of prostate and for its differentiated functions. The consistent expression of AR in prostate cancer (PCa), and its continued activity in PCa that relapse after androgen deprivation ...
Steven P Balk
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source