Results 51 to 60 of about 422,013 (303)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

First-line afatinib vs gefitinib for patients with EGFR mutation-positive NSCLC (LUX-Lung 7): impact of afatinib dose adjustment and analysis of mode of initial progression for patients who continued treatment beyond progression

, 2019
PurposeIn the randomized phase IIb LUX-Lung 7 trial, afatinib significantly improved progression-free survival (PFS) and time-to-treatment failure vs gefitinib in patients with treatment-naive epidermal growth factor receptor mutation-positive non-small ...
O'Byrne, Kenneth, Hirsh, Vera, Schuler, Martin, Paz-Ares, Luis, Zhang, Li, Boyer, Michael, Shi, Yuankai, Maerten, Angela, Mok, Tony, Laskin, Janessa, Yang, James Chih-Hsin, Lee, Ki Hyeong, Kim, Dong-Wan, Arvis, Catherine Dubos, Tan, Eng-Huat, Lu, Shun, Kolbeck, Karl, Massey, Dan, Park, Keunchil, Kim, Sang-We   +19 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Crevicular fluid biomarkers and periodontal disease progression. [PDF]

, 2014
AIM Assess the ability of a panel of gingival crevicular fluid (GCF) biomarkers as predictors of periodontal disease progression (PDP). MATERIALS AND METHODS In this study, 100 individuals participated in a 12-month longitudinal investigation ...
Braun, Thomas M, Morelli, Thiago, Giannobile, William V, Braun, Thomas M., Oh, Min, Sugai, Jim V, Kinney, Janet S., Ramseier, Christoph Andreas, Sugai, Jim V., Giannobile, William V., Ramseier, Christoph A., Kinney, Janet S   +11 more
core   +1 more source

Predictive value of baseline concomitant glucocorticoid for abatacept-mediated long-term inhibition of radiographic progression: insights from the KURAMA cohort

Immunological Medicine
Abatacept (ABT) is a biological disease-modifying antirheumatic drug (bDMARDs) for rheumatoid arthritis (RA) when conventional synthetic DMARDs are ineffective.
Kosaku Murakami, Ryu Watanabe, Toshimitsu Fujisaki, Hiromu Ito, Koichi Murata, Wataru Yamamoto, Takayuki Fujii, Hideo Onizawa, Akira Onishi, Masao Tanaka, Motomu Hashimoto, Akio Morinobu   +11 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Teacher knowledges in school daily life: an analysis in the context of cycles and continued progression

, 2009
Esta pesquisa investiga os saberes mobilizados e construídos pelo professor no trabalho pedagógico para atuar diante dos desafios desencadeados a partir da implantação dos ciclos com progressão continuada.
Bruna da Silva Bezerra, Bezerra, Bruna da Silva   +1 more
core   +1 more source

Risk of disease progression after discontinuing immunotherapy in 105 patients with Merkel cell carcinoma who responded to PD-1 pathway blockade

Journal for ImmunoTherapy of Cancer
Background Immune checkpoint inhibitors (ICIs) are the preferred systemic therapy for most patients with advanced Merkel cell carcinoma (MCC). However, the optimal duration of treatment for patients responding to ICI is unclear.
Shailender Bhatia, Daniel S Hippe, Paul T Nghiem, Candice Church, Tomoko Akaike, Kristina Lachance, Lisa Tachiki, Thomas Pulliam, Song Y Park, Coley Doolittle-Amieva, Lisa Zaba, Nora A Alexander, Emily Gong, Lauren Zawacki, Allison J Remington, Yasman Moshiri, Alex Fu, Emily Huynh, Nikhil Harikrishnan, Marika Bierma   +19 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source