Results 71 to 80 of about 422,013 (303)

On the impossibility of inferring cohort fertility measures from period fertility measures [PDF]

A particularly important struggle faced by demographic analysts is, how to arrive at statements about family formation processes from a cohort perspective from data that are essentially collected on an annual basis.
Evert van Imhoff
core  

Continuing a cancer treatment despite tumor growth may be valuable: sunitinib in renal cell carcinoma as example.

PLoS ONE, 2014
BackgroundThe US FDA and the EMA have approved seven agents for the treatment of renal cell carcinoma, primarily based on differences in progression-free survival (PFS).
Mauricio Burotto, Julia Wilkerson, Wilfred Stein, Robert Motzer, Susan Bates, Tito Fojo   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Career progression: the views of Queensland's nurses

, 2013
Objectives: To inform policy through determination of the views of Queensland nurses on career progression. Design: A quantitative cross-sectional cohort design with mailed survey. Setting: Financial members of the Queensland Nurses' Union.
Eley, Robert, Francis, Karen, Hegney, Desley   +2 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Redistributional Effects of the National Flood Insurance Program [PDF]

This study examines the redistributional effects of the National Flood Insurance Program (NFIP) using a national database of premium, coverage, and claim payments at the county level between 1980 and 2006.
Bin, Okmyung, Bishop, John A., Kousky, Carolyn   +2 more
core  

Nivolumab for Patients With Advanced Melanoma Treated Beyond Progression: Analysis of 2 Phase 3 Clinical Trials [PDF]

, 2017
Immune checkpoint inhibitors have demonstrated atypical response patterns, which may not be fully captured by conventional response criteria. There is a need to better understand the potential benefit of continued immune checkpoint inhibition beyond ...
Jeffrey S. Weber, Catriona McNeil, Márquez-Rodas, Ivan, Georgina V. Long, Karen Briscoe, Weber, Jeffrey S, Larkin, James, Schadendorf, Dirk, Caroline Robert, Weber, Jeffrey S., James Larkin, McNeil, Catriona, Reinhard Dummer, Jean-François Baurain, Robert, Caroline, Long, Georgina V, Henrik Schmidt, Dirk Schadendorf, Ivan Márquez-Rodas, Dummer, Reinhard, Wolchok, Jedd D., Baurain, Jean-François, Grob, Jean-Jacques, Hodi, F Stephen, Jedd D. Wolchok, Briscoe, Karen, Wolchok, Jedd D, Jean-Jacques Grob, F. Stephen Hodi, Schmidt, Henrik, Atkinson, Victoria, Long, Georgina V., Victoria Atkinson   +32 more
core   +1 more source

Avelumab plus axitinib for translocation renal cell carcinoma: A case series and literature review

IJU Case Reports
Introduction Patients with translocation renal cell carcinoma (tRCC) have a poor prognosis without standardized treatment. Case presentation The first case was of a 72‐year‐old woman who underwent robot‐assisted partial nephrectomy for a left renal tumor
Kenta Takahashi, Renpei Kato, Daiki Ikarashi, Tomohiko Matsuura, Shigekatsu Maekawa, Mitsugu Kanehira, Ryo Takata, Jun Sugimura, Takaya Abe, Wataru Obara   +9 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Arithmetic Progression-Representing Constants

This work proposes a distinctive function that connects each arithmetic progression to a particular irrational constant, which is then employed in a recurrence relation to systematically reproduce the sequence.
Antonio Gracia Llorente
core   +1 more source