Results 71 to 80 of about 5,534,457 (290)

Optimal control of continuity equations [PDF]

open access: yesNonlinear Differential Equations and Applications NoDEA, 2016
An optimal control problem for the continuity equation is considered. The aim of a "controller" is to maximize the total mass within a target set at a given time moment. The existence of optimal controls is established. For a particular case of the problem, where an initial distribution is absolutely continuous with smooth density and the target set ...
openaire   +3 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Bayesian Policy Gradients via Alpha Divergence Dropout Inference

open access: yes, 2011
Policy gradient methods have had great success in solving continuous control tasks, yet the stochastic nature of such problems makes deterministic value estimation difficult.
Henderson, Peter   +3 more
core   +3 more sources

Thrombectomy employing continuous radiological control

open access: yesJournal of British Surgery, 1971
Abstract An improved technique of thrombectomy is described. A mobile image intensifier is used throughout the procedure, and the balloon of the Fogarty catheter is inflated with a radio-opaque medium. The advantages of the technique are:— Accurate positioning of the caval occlusion catheter and ...
A O, Mansfield   +2 more
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Reach Control on Simplices by Piecewise Affine Feedback

open access: yes, 2012
We study the reach control problem for affine systems on simplices, and the focus is on cases when it is known that the problem is not solvable by continuous state feedback.
Broucke, Mireille E., Ganness, Marcus
core   +1 more source

Robust Control of Continuous Bioprocesses [PDF]

open access: yesMathematical Problems in Engineering, 2010
This paper deals with robust control of continuous bioprocesses. According to the material balance equations of continuous bioprocesses, a uniform framework for mathematical modeling of this class of processes is first presented. Then a robust controller is designed by using the H∞ mixed sensitivity method for the biotechnology processes.
openaire   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A Physics-Informed Reinforcement Learning Framework for HVAC Optimization: Thermodynamically-Constrained Deep Deterministic Policy Gradients with Simulation-Based Validation

open access: yesEnergies
This paper presents a physics-informed reinforcement learning framework that embeds thermodynamic constraints directly into the policy network of a continuous control agent for HVAC optimization.
Sattar Hedayat   +2 more
doaj   +1 more source

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