Results 81 to 90 of about 5,534,457 (290)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Impact Assessment of Patient Experience Capacity-Building Program Using Kirkpatrick Model for Program Evaluation at a Regional Healthcare System [PDF]

Global Journal on Quality and Safety in Healthcare
Introduction The patient experience (PX) is central to improving the quality of healthcare services. We launched a PX capacity- and capability-building program at the Armed Forces Hospitals Taif Region, which is integral to our regional healthcare ...
Muhammad Hasan Abid, Nada Al Shehri, Shaikh Muhammad Saif Ud Din, Mahmood Mir, Jamal Al Nofeye   +4 more
doaj   +1 more source

Game-theoretical control with continuous action sets

, 2014
Motivated by the recent applications of game-theoretical learning techniques to the design of distributed control systems, we study a class of control problems that can be formulated as potential games with continuous action sets, and we propose an actor-
Leslie, David S., Mertikopoulos, Panayotis, Perkins, Steven   +2 more
core   +1 more source

Continuous-time controlled Markov chains

The Annals of Applied Probability, 2003
The authors consider continuous-time Markov decision processes with a denumerable state space and Borel action space where the cost and the transition rates are allowed to be unbounded. In the class of deterministic stationary policies they first give very weak conditions under which the existence of \(\varepsilon\)-optimal \((\varepsilon\geq 0 ...
Guo, Xianping, Hernández-Lerma, Onésimo   +1 more
openaire   +3 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Occupational risk of bloodborne infections among healthcare workers and strategies for their risk management

Фундаментальная и клиническая медицина
Aim. To identify occupational risks of bloodborne infections among healthcare workers in order to develop effective risk management strategies. Materials and methods.
T. S. Yuzhanina, V. A. Kukarkina, A. A. Golubkova, A. S. Podymova   +3 more
doaj   +1 more source

Continuous-time controlled branching processes

, 2021
In this paper, a controlled branching process with continuous time is introduced and studied in the critical case. First, the authors define controlled branching processes with continuous time and with single and multiple control functions. Two limit theorems are stated in the cases when the mean of the renewal periods is either finite or infinite. The
del Puerto, Inés M., Yanev, George P., Molina, Manuel, Yanev, Nikolay M., González, Miguel   +4 more
openaire   +3 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Continuous and Pulsed Quantum Control

Proceedings, 2019
We consider two alternative procedures which can be used to control the evolution of a generic finite-dimensional quantum system, one hinging upon a strong continuous coupling with a control potential and the other based on the application of frequently ...
Giovanni Gramegna, Daniel Burgarth, Paolo Facchi, Saverio Pascazio   +3 more
doaj   +1 more source