Results 81 to 90 of about 88,361 (301)

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

A Non-Linear Model for Corrosion Fatigue Lifetime Based on Continuum Damage Mechanics

MATEC Web of Conferences, 2018
Many structures, such as oil platforms and wind turbines, are built in the marine environment. These structures do not merely suffer from variable cyclic loading due to wind, waves and current, but also from corrosion.
Zhang Jie, Hertelé Stijn, De Waele Wim
doaj   +1 more source

Strain-based theoretical fatigue damage model of woven glass-epoxy fabric composite material

Composites Part C: Open Access, 2020
Strain-based theoretical fatigue damage model is developed by utilizing internal variable theory of thermodynamics of continuum damage mechanics approach related to woven glass fabric composite material.
Indra Narayan Yadav, Dr. Kamal Bahadur Thapa   +1 more
doaj   +1 more source

Preferences for post‐traumatic osteoarthritis prevention strategies in individuals with anterior cruciate ligament injury

Arthritis Care &Research, Accepted Article.
Objectives There is growing interest in evaluating new strategies to delay or prevent post‐traumatic osteoarthritis (PTOA) in individuals who have sustained anterior cruciate ligament (ACL) injury. This study sought to determine characteristics of potential treatments that are acceptable to patients with ACL injury.
Kevin Kennedy, Lily Waddell, Adam Easterbrook, Jeffrey N. Katz, Cale Jacobs, Morgan Jones, Faith Selzer, Elena Losina, Liana Fraenkel, Nick Bansback   +9 more
wiley   +1 more source

Exploring Patients’ Profiles Associated With the Resolution of Acute Calcium Pyrophosphate Arthritis Treated With Colchicine and Prednisone: Post Hoc Analysis of a Randomized Controlled Trial

Arthritis Care &Research, EarlyView.
Objective The objective was to identify factors determining acute arthritis resolution and safety with colchicine and prednisone in acute calcium pyrophosphate (CPP) crystal arthritis. Methods We conducted a post hoc analysis of the COLCHICORT trial, which compared colchicine and prednisone for the treatment of acute CPP crystal arthritis, using a ...
Tristan Pascart, Laurène Norberciak, Pascal Richette, Pierre Robinet, Aurore Pacaud, Gauthier Marchasson, Thibault Rabin, Hélène Luraschi, Pierre Maciejasz, Anne‐France Georgel, Augustin Latourte, Hang‐Korng Ea, Sébastien Ottaviani, Charlotte Jauffret, Vincent Ducoulombier   +14 more
wiley   +1 more source

The Foundations of Continuum Damage Mechanics

Proceedings of International Structural Engineering and Construction, 2019
Damage Mechanics has become a useful theory in describing the nonlinear behavior of solids driven by the nucleation and growth of cracks and microcracks. This approach, based on the first principles of mechanics and thermodynamics, has also been combined with classical theories of plasticity to address a wide range of loading applications.
Nazari, Hossein, Borgensen, Sevenn, Yazdani, Siamak, GÜRGÜN, Aslı Pelin   +3 more
openaire   +3 more sources

Application of continuum damage mechanics for prediction of wear in tillage tools

Smart Agricultural Technology
Wear of tillage tools by hard soil particles is a serious concern in the industry since wear is the primary factor that defines an engaging tool's lifespan, stability, and reliability. Many studies have primarily focused on experimental methods to better
Sahar Ghatrehsamani, Mohammad Silani, Saleh Akbarzadeh, Shirin Ghatrehsamani   +3 more
doaj   +1 more source

Application of a Microstructure-Based ISV Plasticity Damage Model to Study Penetration Mechanics of Metals and Validation through Penetration Study of Aluminum

Modelling and Simulation in Engineering, 2017
A developed microstructure-based internal state variable (ISV) plasticity damage model is for the first time used for simulating penetration mechanics of aluminum to find out its penetration properties. The ISV damage model tries to explain the interplay
Yangqing Dou, Yucheng Liu, Youssef Hammi, Wilburn Whittington   +3 more
doaj   +1 more source

Fractional Calculus for Continuum Mechanics - anisotropic non-locality

, 2015
In this paper the generalisation of previous author's formulation of fractional continuum mechanics to the case of anisotropic non-locality is presented. The considerations include the review of competitive formulations available in literature.
Sumelka, Wojciech
core   +1 more source