Results 91 to 100 of about 25,888 (262)

URGENCY OF COMBINED ORAL CONTRACEPTIVES IN PROLONGED REGIMEN USE

Акушерство, гинекология и репродукция, 2016
This article presents the issues on combined oral contraceptives use in prolonged regimen.
A. L. Tikhomirov, A. A. Ledenkova
doaj  

Viral Dynamic Model‐Informed Dose Selection of Mosnodenvir Prophylaxis against DENV‐3 in a Controlled Human Infection Model

Clinical Pharmacology &Therapeutics, EarlyView.
Dengue virus (DENV) infection is a significant global health threat. Mosnodenvir (JNJ‐64281802) is a pan‐serotype small molecule antiviral blocking DENV replication. A Phase IIa study (NCT05048875) evaluated the antiviral activity, safety, and pharmacokinetics of mosnodenvir as prophylaxis against DENV‐3 in a controlled human infection model (CHIM).
Nele Goeyvaerts, Xavier Woot de Trixhe, Martine Neyens, Thomas N. Kakuda, Liesbeth Van Wesenbeeck, Annemie Buelens, Freya Rasschaert, Anna Durbin, Oliver Ackaert   +8 more
wiley   +1 more source

Long‐Acting Therapeutics in Pediatric Health: Bridging Innovation and Access

Clinical Pharmacology &Therapeutics, EarlyView.
Children have distinct therapeutic needs arising from age‐dependent physiology, disease epidemiology, formulation requirements, dosing considerations, and safety vulnerabilities. Despite substantial reductions in childhood mortality over the past three decades, nearly 5 million children under five died in 2023, with infectious diseases continuing to ...
Prajith Venkatasubramanian, Moherndran Archary, Daniel B. Hawcutt, Rachel Daley, Edmund Capparelli, Adeniyi Olagunju   +5 more
wiley   +1 more source

When rare conditions collide: plantar vein thrombosis in hereditary spherocytosis

Journal of the Foot & Ankle
Plantar heel pain is a common orthopedic complaint, but less frequent etiologies like plantar vein thrombosis (PVT) are often overlooked. We present the case of a 27-year-old female with a history of hereditary spherocytosis who developed left plantar ...
Budak Akman, Behic Celik, Betul Uzunoglu
doaj   +3 more sources

Postabortal rehabilitation – aspects of the problem: possibilities of combined oral contraceptives

Гинекология, 2013
The article presents modern concepts of pharmacological possibilities to use combined oral contraceptives for prevention of various postabortal complications, rational approaches of their use in female patients in postabortal period.
M B Khamoshina, I S Savelyeva, E A Zorina, M S Tulupova, T N Zulumyan   +4 more
doaj  

Exposure‐Response Analyses of Datopotamab Deruxtecan (Dato‐DXd), a TROP2‐Directed Antibody‐Drug Conjugate, in Advanced Non‐small Cell Lung Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Exposure‐response analyses supported a favorable benefit‐risk profile of Dato‐DXd at 6 mg/kg Q3W in patients with advanced nonsquamous NSCLC. Datopotamab deruxtecan (Dato‐DXd) is a trophoblast cell‐surface antigen‐2 (TROP2)‐directed antibody‐drug conjugate (ADC) that has demonstrated clinical activity in patients with NSCLC who have received prior ...
Ying Hong, Anna M. Mc Laughlin, Yuzhuo Pan, Sofia Friberg Hietala, Sophie Peigné, Michael Chargualaf, Zoey Tang, Diansong Zhou, Naoyuki Tajima, Malaz Abutarif, Tushar Garimella   +10 more
wiley   +1 more source

Combined oral contraceptives: evolution of the relationship benefit/risk

Безопасность и риск фармакотерапии, 2018
Currently, more than 100 million women worldwide use combined oral contraceptives. Risk/benefit ratio of this group of drugs over the half-century history is largely changed in the direction of safety.
O. S. Alyautdina
doaj  

From Prediction to Decision Making: PBPK and QSP as Regulatory‐Grade NAMs

Clinical Pharmacology &Therapeutics, EarlyView.
New approach methodologies (NAMs) encompass a diverse and rapidly evolving set of experimental and computational tools designed to generate human‐relevant mechanistic data for use in drug development and regulatory decision making. Experimental NAMs provide insights into drug disposition, pharmacological activity, and disease biology that are difficult
Karen Rowland Yeo, Piet H. van der Graaf
wiley   +1 more source

Evaluating Vaginal Microbiome Effects on Antiretroviral Exposure in the Female Genital Tract Using Pharmacometric and Machine Learning Approaches

Clinical Pharmacology &Therapeutics, EarlyView.
Antiretroviral pre‐exposure prophylaxis (PrEP) is less effective in women than expected, partly because drug exposure within the female genital tract is variable and may be influenced by the vaginal microbiome. We developed an integrated pharmacometrics and machine learning framework to evaluate associations between vaginal microbiome composition and ...
Diqin Yan, Lindsey B. Collins, Christopher Staley, Flavia Kiweewa Matovu, Pamala Jacobson, Melanie Nicol, Shen Cheng   +6 more
wiley   +1 more source

Cross‐sectional and longitudinal metabolomics‐based profiles associated with oral contraceptive and progestin‐only pill use: A Finnish population‐based study

Acta Obstetricia et Gynecologica Scandinavica
Introduction The use of combined oral contraceptives (COCs), but not of progestin‐only pills (POPs) is associated with an increased risk of cardiovascular events.
Elena Toffol, Jari Haukka, Pekka Jousilahti, Lara Lehtoranta, Anni Joensuu, Timo Partonen, Iris Erlund, Oskari Heikinheimo   +7 more
doaj   +1 more source