Results 81 to 90 of about 24,452 (260)

Endogenous melatonin partial metabolic clearance as a potential endogenous marker of CYP1A2 activity

British Journal of Clinical Pharmacology, EarlyView.
Aims Cytochrome P450 1A2 (CYP1A2) exhibits substantial interindividual variability, necessitating appropriate phenotyping strategies for personalized pharmacotherapy. This study evaluated endogenous melatonin partial metabolic clearance (CLm(MEL)), calculated from urinary 6‐hydroxymelatonin (6‐O‐MEL) excretion and plasma melatonin (MEL) exposure, as a ...
Akitomo Yokokawa, Hayato Shimazaki, Shunji Igarashi, Yoshiki Tagawa, Naoki Hisada, Hiromi Shibasaki   +5 more
wiley   +1 more source

Combined Oral Contraceptives and the Risk of Thrombosis

International Journal of Molecular Sciences
Combined oral contraceptives (COCs) remain one of the most popular reversible contraceptive methods worldwide. Still, regardless of the drug composition and duration of therapy, almost all COCs are associated with the risk of venous thrombosis. This review highlights the main pathogenetic mechanisms of thrombosis development during oral contraceptive ...
Jamilya Khizroeva, Victoria Bitsadze, Gennady Sukhikh, Maria Tretyakova, Jean-Christophe Gris, Ismail Elalamy, Grigoris Gerotziafas, Daredzhan Kapanadze, Margaret Kvaratskheliia, Alena Tatarintseva, Azaliia Khisamieva, Ivan Hovancev, Fidan Yakubova, Alexander Makatsariya   +13 more
openaire   +2 more sources

Identification of antibiotic allergies in children using prescribing patterns in the electronic medical record

British Journal of Clinical Pharmacology, EarlyView.
Background By age three, 5%–75% of children have a documented antibiotic allergy (AL). Despite this prevalence, recognition remains low because of limited clinician knowledge and time. Our study evaluates a novel approach to identifying AL using electronic medical record (EMR) prescription patterns.
Georgia Koutsaplis, Kailey Tang, Renee Dimond, Alice Lei, Amanda Wilkins, Amanda Gwee   +5 more
wiley   +1 more source

Oseltamivir drug‐disease modelling in infants with influenza virus infection

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Oseltamivir is a commonly used neuraminidase inhibitor for treatment of influenza infection, but little data exist regarding concentration‐response relationships. Methods Pharmacokinetic (PK) and viral dynamic data from an earlier NIAID Collaborative Antiviral Study Group trial in paediatric patients with influenza from 0–23 months of age
Kun Wang, David W. Kimberlin, Richard J. Whitley, Edward P. Acosta, For the National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group   +4 more
wiley   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

BMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang, Yushan Zhang, Hang Li, Sirui Peng, Donghao Lyu, Chunxiao Zhou, Sheng Ding, Zujian Feng, Pingsheng Huang, Chuangnian Zhang, Hongjun Wang, Deling Kong, Weiwei Wang   +12 more
wiley   +1 more source

Effect of combined oral contraceptives on orthodontic tooth movement in a female rat model

Australasian Orthodontic Journal, 2019
To investigate the effect of combined oral contraceptives (COC) on orthodontic tooth movement (OTM) and periodontal remodelling in a female rat model.
Yu Jinghong, Zhou Yifei, Zhang Tao, Lv Jialing, Firth Fiona, Zhao Xian, Xu Xiaomei, Mei Li   +7 more
doaj   +1 more source

Intraosseous sarcoidosis imitating peri‐implantitis: A case study

Clinical Advances in Periodontics, EarlyView.
Abstract Background Sarcoidosis is a multisystem granulomatous disorder of unknown cause, typically affecting the lungs and lymph nodes, but it can also involve the eyes, skin, heart, bones, and other organs. The exact cause is unclear, but genetic factors and environmental triggers like infections, chemicals, or dust may play a role.
Magdalena Orlowska, David S. Gottlieb, Kenneth S. Kornman   +2 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

URGENCY OF COMBINED ORAL CONTRACEPTIVES IN PROLONGED REGIMEN USE

Акушерство, гинекология и репродукция, 2016
This article presents the issues on combined oral contraceptives use in prolonged regimen.
A. L. Tikhomirov, A. A. Ledenkova
doaj  

Laterally positioned flap with connective tissue graft to treat deep isolated gingival recessions in the mandibular anterior region: A retrospective case series with 10‐year follow‐up

Clinical Advances in Periodontics, EarlyView.
ABSTRACT Background To evaluate the efficacy and long‐term clinical outcomes of the one‐stage procedure for covering isolated deep gingival recessions (GRs) in the mandibular anterior region employing a laterally positioned flap (LPF) with a connective tissue graft (CTG), with a retrospective case series.
Lucrezia Parma‐Benfenati, Stefano Parma‐Benfenati   +1 more
wiley   +1 more source