Results 181 to 190 of about 13,466 (296)

Control local de un sistema no lineal: el péndulo con rueda de reacción

, 2009
En este documento se presentan técnicas de control de sistemas físicos no lineales alrededor de puntos de operación. Se introducen los conceptos de linealización parcial y exacta y se presentan los resultados obtenidos al aplicar estos métodos no ...
Giraldo Buitrago, Didier, Correa R., Víctor Daniel   +1 more
core   +1 more source

Telomeric G-quadruplex intermediates unveiled by complex Markov network analysis. [PDF]

Sci Rep
Sáinz-Agost A, Falo F, Fiasconaro A.
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Microdosimetry calculations in situ for clinically relevant photon sources and their correlation with the early DNA damage response. [PDF]

Med Phys
Dumančić M, Kalinowski J, Diaz-Martinez VD, Li J, Behmand B, DeCunha JM, Enger SA.   +6 more
europepmc   +1 more source

Diseño, construcción y control de un péndulo invertido rotacional utilizando técnicas lineales y no lineales

, 2009
Este trabajo presenta el desarrollo y control de un péndulo invertido rotacional (péndulo de Furuta). Un ejemplo de este tipo de sistemas son las aeronaves, vehículos espaciales, vehículos submarinos, barcos, satélites y robots construidos por barras y uniones articuladas pasivas y activas. Algunas veces, la subactuación puede ser causada por fallas en
openaire   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Evaluation of relative biological effectiveness of ²²⁵Ac and its decay daughters with Monte Carlo track structure simulations. [PDF]

EJNMMI Phys
Hu Z, Qu S, Liu H, Zhang Y, Yan S, Hu A, Qiu R, Wu Z, Zhang H, Li J.   +9 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Serum metabolic and microbial profiling yields insights into promoting effect of tryptophan-related metabolites for health longevity in centenarians. [PDF]

Imeta
Qiu X, Mu C, Hu J, Yu J, Tang W, Liu Y, Huang Y, Lu Y, Tang P, Wu J, Huang Z, Mei X, Xiang H, Lin H, Qi Y, Luo H, Li X.   +16 more
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source