Results 171 to 180 of about 6,305 (264)

Differences in Smooth Pursuit and Associated Saccades in Children With Two Common Types of Strabismus. [PDF]

Invest Ophthalmol Vis Sci
Sanz E, Aivar MP, Tejedor J.
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Acute leukemia of ambiguous lineage: the known and the uncertain. [PDF]

Haematologica
Sherban A, Wolach O.
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Cell lineage-resolved embryonic morphological map reveals signaling associated with cell fate and size asymmetry. [PDF]

Nat Commun
Guan G, Li Z, Ma Y, Ye P, Cao J, Wong MK, Ho VWS, Chan LY, Yan H, Tang C, Zhao Z.   +10 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Interpreting the biological effects of protons as a function of physical quantity: linear energy transfer or microdosimetric lineal energy spectrum? [PDF]

Sci Rep
Guan F, Bronk L, Kerr M, Li Y, Braby LA, Sobieski M, Wang X, Zhang X, Stephan C, Grosshans DR, Mohan R.   +10 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Experimental datasets on synchronization in simplicial complexes. [PDF]

Data Brief
Vera-Ávila VP, Rivera-Durón RR, Orozco-López O, Soriano-García MS, Sevilla-Escoboza JR, Buldú JM.   +5 more
europepmc   +1 more source

Control de procesos multivariables no lineales empleando lógica difusa

, 1995
Los procesos involucrados en ramas como la Ingeniería Química resultan ser de naturaleza no lineal; algunos de ellos, como los procesos de destilación, presentan fuertes no linealidades y acoplamiento entre variables de proceso. Típicamente, las técnicas convencionales de control usadas en este tipo de equipo tienen involucrados controladores del tipo ...
openaire   +1 more source