Results 31 to 40 of about 6,305 (264)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Tuning of Pareto-optimal robust controllers for multivariable systems. Application on helicopter of two-degress-of-freedom

Revista Iberoamericana de Automática e Informática Industrial RIAI, 2015
The tuning of Pareto-optimal robust controllers was applied to improve the performance of a helicopter with two-degrees-of-freedom with a linear control algorithm.
J. Carrillo Ahumada, G. Reynoso Meza, S. García Nieto, J. Sanchis, M.A. García Alvarado   +4 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Robust Controller LMI for helicopter with two degrees of freedom

Ingeniería Investigación y Desarrollo, 2015
This article presents the design of a robust H∞ controller using techniques of linear matrix inequalities (LMIs) for controlling the position of Pitch and Yaw in a helicopter.
Oscar Iván Higuera-Martínez, Juan Mauricio Salamanca   +1 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Control no lineal robusto de una maqueta de helicóptero con rotores de velocidad variable

Revista Iberoamericana de Automática e Informática Industrial RIAI, 2007
Resumen: En este artículo se presenta el diseño de un controlador robusto no lineal para un helicóptero de laboratorio. El equipo se caracteriza por tener los ángulos de ataque de las hélices de los rotores fijos y se controla mediante el cambio de ...
Manuel López-Martínez, Manuel G. Ortega, Carlos Vivas, Francisco R. Rubio   +3 more
doaj   +1 more source

Resultados teóricos y numéricos de control para EDPs lineales y no lineales

, 2015
En esta Tesis presentamos resultados teóricos y numéricos de control para EDPs lineales y no lineales. Primeramente, en el Capítulo 2, analizamos el control nulo local del modelo de Burgers-α. El estado es una solución de una ecuación de Burgers regularizada, donde el ́ termino de transporte es de la forma zyx, z = (Id − α 2 ∂ 2 ∂x2 ) −1y y α > 0 es un
openaire   +3 more sources