Results 31 to 40 of about 14,650 (266)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Adaptive flight control for unmanned autonomous helicopter with external disturbance and actuator fault

The Journal of Engineering, 2019
A backstepping-based robust adaptive fault tolerant control (FTC) scheme is proposed for the altitude and attitude dynamic model of the medium-scale unmanned autonomous helicopter (UAH) subjected to external disturbance and actuator fault.
Kun Yan, Mou Chen, Qingxian Wu, Yuhui Wang   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Finite‐time stabilization control of nonlinear systems with full‐state constraints

IET Control Theory & Applications
This paper studies the finite time stabilization control (FTSC) problem of nonlinear systems with unknown functions and full‐state constraints (FSCs).
Jianwen Liu, Xiao Yan, Lin Zhang, Fujin Jia, Ni Yang   +4 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Control Profile Derivation for Collision Imminent Steering via Solutions of Large-Scale Optimization Problem

IEEE Access
In collision-imminent situations where braking alone is insufficient, integrated steering control is an effective avoidance measure. However, a generalized strategy that minimizes the required avoidance distance by fully leveraging a vehicle’s ...
Chanwoo Heo, Gayoen Ahn, Aldo Sorniotti, Seunghoon Woo   +3 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Nonlinear Control

, 2017
Nonlinear behavior is the general rule in physics and nature. Linear models, obtained by linearization or identification, are in general crude approximations of nonlinear behaviors of plants in the neighbourhood of an operating point. However, in many cases such as startup, shutdown, or important transient regimes, study of batch and fed-batch ...
openaire   +2 more sources

Development of a Nonlinear Model Predictive Control-Based Nonlinear Three-Mode Controller for a Nonlinear System

ACS Omega, 2022
This paper presents the novelty on a nonlinear proportional integral derivative (NPID) controller developed from the gain values obtained using the Lyapunov-based nonlinear model predictive controller (LyNMPC). The tuning parameters of the proposed controller are taken from the dynamics of the nonlinear system, and these parmeters are dynamic with ...
Suraj Suresh Kumar, Thirunavukkarasu Indiran, George Vadakkekkara Itty, Prajwal Shettigar J, Tinu Valsa Paul   +4 more
openaire   +2 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source