Results 41 to 50 of about 1,006,785 (263)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Exposure system for animals Patent [PDF]

, 1968
System for continuous monitoring of exhalations, weighing, and cage cleaning for animal exposed to controlled atmosphere for toxic ...
Quattrone, P. D., Staley, R. W.
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Controlled Atmosphere Stunning [PDF]

Controlled atmosphere (CAS) stunning includes several variations of gaseous mixtures given to induce an anaesthetic state before slaughter poultry. One method of multi phase CAS is to unload the birds out of the crate on a conveyor belt and subject the ...
Gerritzen, M.A., Lambooij, E.
core   +1 more source

Controlled-atmosphere thermal demagnetization and paleointensity analyses of extraterrestrial rocks [PDF]

, 2013
We describe a system for conducting thermal demagnetization of extraterrestrial rocks in a controlled atmosphere appropriate for a wide range of oxygen fugacities within the stability domain of iron.
Aitken, Benjamin P. Weiss, Bowles, Brecher, Brett, Burkhard, Cacciamani, Chowdhary, Clément Suavet, Coe, Collinson, Collinson, Cournède, Day, Dunlop, Dunn, Eugster, Fuller, Fuller, Garrick-Bethell, Garrick-Bethell, Gattacceca, Goodrich, Gose, Grove, Halgedahl, Hewins, Hoffman, Huebner, Kirschvink, Kletetschka, Larson, Lawrence, Levi, Morden, Nafziger, Nagata, Néel, Pearce, Prunier, Righter, Sato, Shaar, Shea, Suavet, Sugiura, Sugiura, Sugiura, Tauxe, Tauxe, Taylor, Taylor, Thellier, Tikoo, Timothy L. Grove, Ulmer, Wadhwa, Wang, Weiss, Westphal, Westphal, Yu, Yu, Yu, Zen   +64 more
core   +1 more source

Insights into a long life without cancer: The case of the bowhead whale

Molecular Oncology, EarlyView.
Long‐lived, large‐bodied organisms have evolved powerful anticancer mechanisms that preserve cellular and tissue integrity across extended lifespans. A recent study by Firsanov et al. shows that greater genome stability is a key factor underlying the remarkable longevity and cancer resistance of one such species, the bowhead whale.
Inés Paniagua, Johanna A. Joyce
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Carbon Nanotubes by a CVD Method. Part I: Synthesis and Characterization of the (Mg, Fe)O Catalysts [PDF]

, 2002
The controlled synthesis of carbon nanotubes by chemical vapor deposition requires tailored and wellcharacterized catalyst materials. We attempted to synthesize Mg1-xFexO oxide solid solutions by the combustion route, with the aim of performing a ...
Alvarez W. E., Bacsa R. R., Bacsa R. R., Berthet A. Ph.D., Bhide V. G., Blank S. L., Boudart M., Brynestad J., Carles V., Coquay P., Coquay P., De Bakker P. Ph.D., De Grave E., Flahaut E., Flahaut E., Govindaraj A., Hafner J. H., Herrera J. E., Holland T. J. B., Jain S. R., Jing J., Kingsley J. J., Krawitz A., Laurent, Laurent, Li Y., Patil K. C., Peigney A., Peigney A., Peigney A., Perez A., Quénard O., Simkin D. J., Topsoe H., Trinel-Dufour M. C., Vandenberghe R. E., Waychunas G. A., Woods K. N., Yamaguchi G., Zhang Y.   +39 more
core   +3 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source