Results 81 to 90 of about 1,001,835 (291)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Comparative efficacy of controlled atmospheres against two stored product insects
Journal of Crop Protection, 2013 Effect of controlled atmospheres (CAs) at various concentrations of CO2, N2 and O2 on the lethal times of Tribolium castaneum and Trogoderma granarium was investigated at 20 and 30 ºC.
Mohamed Azab +3 more
doaj
Responses of Pigs to Stunning with Nitrogen Filled High-Expansion Foam
Animals, 2020 Nitrogen gas (N2) delivered in high expansion foam in a closed container could be a feasible method for humanely stunning pigs. This study aimed to evaluate potential aversion in pigs to the N2 foam method and its effect on stun quality. Furthermore, the
Cecilia Lindahl +4 more
doaj +1 more source
A passive sampling method for radiocarbon analysis of atmospheric CO2 using molecular sieve [PDF]
, 2010 Radiocarbon (14C) analysis of atmospheric CO2 can provide information on CO2 sources and is potentially valuable for validating inventories of fossil fuel-derived CO2 emissions to the atmosphere.
Garnett, M.H., Hartley, I.P.
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Effects of pre- and postharvest factors on browning in Braeburn
Horticultural Science, 2014 The effects of several pre- and postharvest factors on apple cv. Braeburn browning disorder (BBD) incidence using a nine-factor experimental design has been investigated.
D. Hatoum +6 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Revista Brasileira de Engenharia Agrícola e Ambiental, 2002 Avaliar a qualidade da farinha obtida de grãos de trigo fumigados com atmosfera sintética (21% de CO2) associada a níveis reduzidos de fosfina (0,25, 0,50 e 0,75 g m-3) foi o que se objetivou através deste trabalho.
Lêda R. D. Faroni +3 more
doaj +1 more source