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Journal of Neurochemistry, 2021 α-Conotoxins are small disulfide-rich peptides found in the venom of marine cone snails and are potent antagonists of nicotinic acetylcholine receptors (nAChRs).
Han-Shen Tae +2 more
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Antioxidant Peptides from the Protein Hydrolysates of Conus betulinus
International Journal of Peptide Research and Therapeutics, 2011The current study aims at the isolation and characterization of the peptides, believed to have antioxidant activity, from Conus betulinus by using different types of enzymes. The body and viscera of C. betulinus were treated with three enzymes viz. trypsin, pepsin and papain to obtain peptide hydrolysates.
Rasool Abdul Nazeer
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Synthesis and insecticidal activity of cysteine-free conopeptides from Conus betulinus
Toxicon, 2023The cone snail Conus betulinus is a vermivorous species that is widely distributed in the South China Sea. Its crude venom contains various peptides used to prey on marine worms. In previous studies, a systematic analysis of the peptide toxin sequences from C. betulinus was carried out using a multiomics technique.
Jiao, Chen +3 more
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A Novel Conotoxin from Conus betulinus, κ-BtX, Unique in Cysteine Pattern and in Function as a Specific BK Channel Modulator* [PDF]
Journal of Biological Chemistry, 2003 A novel conotoxin, kappa-conotoxin (kappa-BtX), has been purified and characterized from the venom of a worm-hunting cone snail, Conus betulinus. The toxin, with four disulfide bonds, shares no sequence homology with any other conotoxins. Based on a partial amino acid sequence, its cDNA was cloned and sequenced.
Chris Ulens, Jan Tytgat, Cheng-Wu Chi
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Journal of Neurochemistry, 2021
Abstractα‐Conotoxins are small disulfide‐rich peptides found in the venom of marine cone snails and are potent antagonists of nicotinic acetylcholine receptors (nAChRs). They are valuable pharmacological tools and have potential therapeutic applications for the treatment of chronic pain or neurological diseases and disorders.
Huying Ning +9 more
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Abstractα‐Conotoxins are small disulfide‐rich peptides found in the venom of marine cone snails and are potent antagonists of nicotinic acetylcholine receptors (nAChRs). They are valuable pharmacological tools and have potential therapeutic applications for the treatment of chronic pain or neurological diseases and disorders.
Huying Ning +9 more
openaire +2 more sources
Isolation and Characterization of Conotoxin bt5a from <I>Conus betulinus</I>
Chinese Journal of Natural Medicines, 2010Ji-Sheng Chen
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Isolation and Characterization of Conotoxin bt5a from Conus betulinus
Chinese Journal of Natural Medicines, 2010Abstract Aim To study the chemical constituents of the venom of Conus betulinus that collected from South China Sea. Methods Gel chromatography and HPLC were applied to isolate toxins from the venom of Conus betulinus and a peptide toxin was obtained.
Xian-Dong DAI +5 more
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Contryphan-Bt: A pyroglutamic acid containing conopeptide isolated from the venom of Conus betulinus
Toxicon, 2017A new member of the contryphans family was isolated from the venom of Conus betilinus, a vermivorous species distributed in the South China Sea. Its sequence, ZSGCO(D-W)KPWC-NH2 (Z, pyroglutamic acid), was established by a combination of de novo MS/MS sequencing and venom-duct transcriptome sequencing. The occurrence of D-Trp6 was confirmed by chemical
Penggang Han +7 more
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