Results 1 to 10 of about 3,898 (208)

The mitochondrial genome of the venomous cone snail Conus consors. [PDF]

PLoS ONE, 2012
Cone snails are venomous predatory marine neogastropods that belong to the species-rich superfamily of the Conoidea. So far, the mitochondrial genomes of two cone snail species (Conus textile and Conus borgesi) have been described, and these feed on ...
Age Brauer, Alexander Kurz, Tim Stockwell, Holly Baden-Tillson, Juliana Heidler, Ilka Wittig, Silke Kauferstein, Dietrich Mebs, Reto Stöcklin, Maido Remm   +9 more
doaj   +16 more sources

Glowing seashells: diversity of fossilized coloration patterns on coral reef-associated cone snail (Gastropoda: Conidae) shells from the Neogene of the Dominican Republic. [PDF]

PLoS ONE, 2015
The biology of modern Conidae (cone snails)--which includes the hyperdiverse genus Conus--has been intensively studied, but the fossil record of the clade remains poorly understood, particularly within an evolutionary framework.
Jonathan R Hendricks
doaj   +7 more sources

Conkazal-M1 from the MKAVA family of conotoxins: A dual-function protease inhibitor and neuroactive peptide. [PDF]

Protein Sci
Abstract Marine cone snails produce a diverse array of bioactive peptides, known as conotoxins, in their venom. Given their high target potency and specificity, conotoxins are attractive compounds for the development of precision research tools and pharmacological agents.
Hackney CM, Koch TL, Ryding NL, Rogalski A, Chase K, Giglio ML, Espino SS, Acyatan ZG, Watkins M, Olivera BM, Safavi-Hemami H, Teilum K, Ellgaard L.   +12 more
europepmc   +2 more sources

Profiling the Paralytic Effects and Lethality of Cone Snail Venom Toxins Using Nanofractionation Analytics with In Vivo Zebrafish Larvae Assays [PDF]

Toxins
This study presents nanofractionation analytics coupled with in vivo profiling of zebrafish embryo paralysis and lethality in response to toxins in cone snail venoms.
Jeroen Kool, Arif Arrahman, Haifeng Xu, Jiaxing Liu, Richard J. Lewis, Christian Tudorache, Fernanda C. Cardoso   +6 more
doaj   +2 more sources

Geographic Variation in Diet and Genetic Connectivity of Populations of the Widespread Predatory Cone Snail <i>Conus miliaris</i>. [PDF]

Ecol Evol
We examined patterns of dietary and genetic variation of a broadly distributed, Indo‐West Pacific cone snail at four sites in French Polynesia and compared them to populations at Guam, American Samoa, and Rapa Nui. Our results indicate that populations at French Polynesia possess broad and overlapping diets that are most similar to those of Rapa Nui ...
Duda TF, Vergara-Flórez DC.
europepmc   +2 more sources

Structural similarities reveal an expansive conotoxin family with a two-finger toxin fold. [PDF]

Protein Sci
Abstract Venomous animals have evolved a diverse repertoire of toxins with considerable pharmaceutical potential. The rapid evolution of peptide toxins, such as the conotoxins produced by venomous marine cone snails, often complicates efforts to infer their evolutionary relationships based solely on sequence information.
Khilji MS, Hackney CM, Koch TL, Hone AJ, Rogalski A, Watkins M, Tun J, McIntosh JM, Olivera B, Safavi-Hemami H, Teilum K, Ellgaard L.   +11 more
europepmc   +2 more sources

Fingerprint Analysis and Comparison of Activity Differences of Crude Venom from Five Species of Vermivorous Cone Snail in the South China Sea [PDF]

Marine Drugs
The South China Sea is rich in cone snail resources, known for producing conotoxins with diverse biological activities such as analgesic, anticancer, and insecticidal effects.
Shibo Sun, Yanling Liao, Jinxing Fu, Yanxia Liang, Yurong Chen, Kailin Mao, Bingmiao Gao   +6 more
doaj   +2 more sources

Cysteine pattern barcoding-based dataset filtration enhances the machine learning-assisted interpretation of Conus venom peptide therapeutics. [PDF]

PLoS ONE
Crude cone snail venom is a rich source of bioactive compounds with significant therapeutic potential. In this study, we conducted a comprehensive analysis of 5,985 cone snail peptides across 82 Conus species to identify unique cysteine (Cys) patterns ...
Rimsha Bibi, Noshaba Qasmi, Sajid Rashid
doaj   +2 more sources

A Conceptual Review of Naturally Occurring Toxins and Venoms as Peptide Blockers to Combat Chronic Low Back Pain. [PDF]

JOR Spine
This review explores the therapeutic potential of naturally occurring venom‐derived peptides, particularly from reptiles and insects, as novel calcium channel blockers for managing chronic low back pain caused by intervertebral disc degeneration.
Melrose J, Sima S, Chopra N, Diwan A, Gu Z.   +4 more
europepmc   +2 more sources

An N-Terminally Elongated Peptide From Conus rolani Defines a New Class of Ribbon α-Conotoxins Targeting Muscle nAChRs. [PDF]

FASEB J
α‐RoIA is an atypical N‐terminally elongated conotoxin discovered in Conus rolani. N‐terminal elongation delays activity in vivo; however, this elongation must be removed to block muscle nicotinic acetylcholine receptors (nAChRs). Only the truncated ribbon isoform of RoIA blocks muscle nAChRs.
Giglio ML, Flórez-Salcedo P, Azam L, Watkins M, Koch TL, Basgall-De la Rosa E, Douglass AD, McIntosh JM, Olivera BM, Gajewiak J.   +9 more
europepmc   +2 more sources