Results 31 to 40 of about 3,898 (208)

Ecological and population characteristics of the seashell Conus princeps on the Pacific coast of central Mexico

Ciencias Marinas, 2019
Marine snails of the genus Conus have acquired remarkable biomedical importance because of the high number of toxins they produce for feeding and self-defense.
Jesus Emilio Michel-Morfín, Gilberto A Medina-Vargas, Víctor Landa-Jaime, Judith Arciniega-Flores, Manuel B Aguilar, Edgar P Heimer de la Cotera   +5 more
doaj   +1 more source

Cone snail milked venom dynamics – A quantitative study of Conus purpurascens [PDF]

Toxicon, 2012
Milked venom from cone snails represent a novel biological resource with a proven track record for drug discovery. To strengthen this correlation, we undertook a chromatographic and mass spectrometric study of individual milked venoms from Conus purpurascens.
Joycelyn B S, Chun, Margaret R, Baker, Do H, Kim, Majdouline, Leroy, Priamo, Toribo, Jon-Paul, Bingham   +5 more
openaire   +2 more sources

Novel conopeptides of the I-superfamily occur in several clades of cone snails [PDF]

, 2004
The I-superfamily of conotoxins represents a new class of peptides in the venom of some Conus species. These toxins are characterized by four disulfide bridges and inhibit or modify ion channels of nerve cells.
Huys, I., Kauferstein, S., Kuch, U., Mebs, D., Melaun, C., Tytgat, J.   +5 more
core   +1 more source

The first Conus genome assembly reveals a primary genetic central dogma of conopeptides in C. betulinus

Cell Discovery, 2021
Although there are various Conus species with publicly available transcriptome and proteome data, no genome assembly has been reported yet. Here, using Chinese tubular cone snail (C.
Chao Peng, Yu Huang, Chao Bian, Jia Li, Jie Liu, Kai Zhang, Xinxin You, Zhilong Lin, Yanbin He, Jieming Chen, Yunyun Lv, Zhiqiang Ruan, Xinhui Zhang, Yunhai Yi, Yanping Li, Xueqiang Lin, Ruobo Gu, Junmin Xu, Jia’an Yang, Chongxu Fan, Ge Yao, Ji-Sheng Chen, Hui Jiang, Bingmiao Gao, Qiong Shi   +24 more
doaj   +1 more source

Gene content of the fish-hunting cone snail Conus consors [PDF]

, 2019
AbstractBackgroundConus consors is a fish-hunting cone snail that lives in the tropical waters of the Indo-Pacific region. Cone snails have attracted scientific interest for the amazing potency of their venom, which consists of a complex mixture of small proteins known as conopeptides, many of which act as ion channel and receptor modulators with high ...
Andreson, Reidar, Roosaare, Märt, Kaplinski, Lauris, Laht, Silja, Kõressaar, Triinu, Lepamets, Maarja, Brauer, Age, Kukuškina, Viktorija, Remm, Maido   +8 more
openaire   +1 more source

A novel Conus snail polypeptide causes excitotoxicity by blocking desensitization of AMPA receptors. [PDF]

Curr Biol, 2009
Ionotropic glutamate receptors (iGluRs) are glutamate-gated ion channels that mediate excitatory neurotransmission in the central nervous system. Based on both molecular and pharmacological criteria, iGluRs have been divided into two major classes, the non-NMDA class, which includes both AMPA and kainate subtypes of receptors, and the NMDA class.
Walker CS, Jensen S, Ellison M, Matta JA, Lee WY, Imperial JS, Duclos N, Brockie PJ, Madsen DM, Isaac JT, Olivera B, Maricq AV.   +11 more
europepmc   +4 more sources

Conus Envenomation of Humans: In Fact and Fiction

Toxins, 2018
Prominent hallmarks of the widely distributed, mainly tropical marine snail genus Conus are: (1) its unusually high species diversity; it is the largest genus of animals in the sea, with more than 800 recognized species; and (2) its specialized feeding ...
Alan J. Kohn
doaj   +1 more source

Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor

eLife, 2019
The fish-hunting marine cone snail Conus geographus uses a specialized venom insulin to induce hypoglycemic shock in its prey. We recently showed that this venom insulin, Con-Ins G1, has unique characteristics relevant to the design of new insulin ...
Peter Ahorukomeye, Maria M Disotuar, Joanna Gajewiak, Santhosh Karanth, Maren Watkins, Samuel D Robinson, Paula Flórez Salcedo, Nicholas A Smith, Brian J Smith, Amnon Schlegel, Briony E Forbes, Baldomero Olivera, Danny Hung-Chieh Chou, Helena Safavi-Hemami   +13 more
doaj   +1 more source

A novel α-conotoxin, PeIA, cloned from Conus pergrandis, discriminates between Rat α9α10 and α7 nicotinic cholinergic receptors [PDF]

, 2005
The α9 and α10 nicotinic cholinergic subunits assemble to form the receptor believed to mediate synaptic transmission between efferent olivocochlear fibers and hair cells of the cochlea, one of the few examples of postsynaptic function for a non-muscle ...
Arredondo, Azam, Baker, Balestra, Bleckmann, Bobbin, Boulter, Cartier, Champtiaux, Chernyavsky, Colquhoun, Conroy, Couturier, Dawkins, Deneris, Drescher, Duvoisin, Elgoyhen, Elgoyhen, Engelmann, Flock, Fuchs, Genzen, Gerzanich, Gerzanich, Glowatzki, Goldman, Gotti, Gotti, Groot-Kormelink, Guinan, Haberberger, Jones, Karlin, Katz, Katz, Kros, Kurzen, Le Novere, Lips, Luebke, Lustig, McIntosh, McIntosh, Mihovilovic, Morley, Nguyen, Nicke, Peng, Pohlmann, Rothlin, Russell, Santos, Sato, Seguela, Sgard, Terlau, Walker, Wals, Weisstaub   +59 more
core   +1 more source

Mitochondrial genome sequencing of a vermivorous cone snail Conus quercinus supports the correlative analysis between phylogenetic relationships and dietary types of Conus species.

PLoS ONE, 2018
Complete mitochondrial genome (mitogenome) sequence of a worm-hunting cone snail, Conus quercinus, was reported in this study. Its mitogenome, the longest one (16,460 bp) among reported Conus specie, is composed of 13 protein-coding genes (PCGs), 22 ...
Bingmiao Gao, Chao Peng, Qin Chen, Junqing Zhang, Qiong Shi   +4 more
doaj   +1 more source