Results 61 to 70 of about 3,596,938 (336)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Problems and ways of development of economy of cooperation in the agricultural sector of the region

Путеводитель предпринимателя, 2020
The article provides suggested approaches for socio-economic development of the system of consumer cooperation in the agro-industrial complex of Russia, in particular the model and shape the further development of consumer cooperatives and directions of ...
S. V. Biryukova, O. A. Mirgorodskaya, G. A. Narozhnaya   +2 more
doaj  

Cooperation Enforcement and Collusion Resistance in Repeated Public Goods Games

, 2018
Enforcing cooperation among substantial agents is one of the main objectives for multi-agent systems. However, due to the existence of inherent social dilemmas in many scenarios, the free-rider problem may arise during agents' long-run interactions and ...
Hao, Dong, Li, Kai
core   +1 more source

COMPULSORY COOPERATION AND COINCIDENTAL COOPERATION

Journal of Positive Management, 2011
The aim of the article is to prove that companies cooperate not only because they wish to, but also because they are forced to do it. Moreover, It turns out that sometimes firms cooperate in strategic alliances with partners which were not selected, but appeared coincidentally.
openaire   +5 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Fan (Fiction) Acting on Media and the Politics of Appropriation

Media and Communication, 2017
Fanfiction is the creative appropriation and transformation of existing popular media texts by fans who take stories, worlds and/or characters as starting points and create their own stories based on them.
Wolfgang Reißmann, Moritz Stock, Svenja Kaiser, Vanessa Isenberg, Jörg-Uwe Nieland   +4 more
doaj   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Educating Higher Education Students for Innovative Economies: What International Data Tell Us

Tuning Journal for Higher Education, 2014
As innovation increasingly fuels economic growth, higher education institutions and systems face the challenge of equipping students with the skills required by innovative economies.
Francesco Avvisati, Gwenaël Jacotin, Stéphan Vincent-Lancrin   +2 more
doaj   +1 more source

Evolution of Cooperation with Heterogeneous Conditional Cooperators [PDF]

Scientific Reports, 2018
AbstractConditional cooperation declines over time if heterogeneous ideal conditional agents are involved in repeated interactions. With strict assumptions of rationality and a population consisting of ideal conditional agents who strictly follow a decision rule, cooperation is not expected. However, cooperation is commonly observed in human societies.
Battu, Balaraju, Pammi, V. S. Chandrasekhar, Srinivasan, Narayanan   +2 more
openaire   +2 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source