Functional Role of COP1 Gene in Hepatocellular Carcinoma Lipid Metabolism and Stemness. [PDF]
Genes CellsCOP1 promotes HCC lipid metabolism and stemness via the functional interaction with AKR1D1 and TMEM65 genes, respectively, indicating its potential as a therapeutic target for treating primary HCC and preventing metastasis and/or recurrence. ABSTRACT We have previously defined the constitutive photomorphogenic protein 1 (COP1) gene as a therapeutic ...
Jeon EH +8 more
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COP1 regulates the abundance and stability of the Arabidopsis retromer protein AtVPS29 via the proteasome pathway [PDF]
Plant Signaling & BehaviorVacuolar protein sorting 29 (VPS29) is a pivotal component of the retromer complex, which plays a central role in endosomal trafficking. Numerous studies have investigated its functions in various eukaryotic systems; however, research in plants is still ...
Wang Ki Min +3 more
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Nuclear export regulation of COP1 by 14-3-3σ in response to DNA damage
Molecular Cancer, 2010 Mammalian constitutive photomorphogenic 1 (COP1) is a p53 E3 ubiquitin ligase involved in regulating p53 protein level. In plants, the dynamic cytoplasm/nucleus distribution of COP1 is important for its function in terms of catalyzing the degradation of ...
Jian Chen, Mong-Hong Lee, Ruiying Zhao
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COP1 drives renal cell carcinoma progression by targeting ACSL4 for ubiquitin-mediated degradation and inhibiting ferroptosis [PDF]
Frontiers in OncologyBackgroundRenal cell carcinoma (RCC) progression is closely linked to dysregulation of the ubiquitin-proteasome system, particularly aberrant ubiquitination processes governing protein degradation and cell cycle control. As a pivotal E3 ubiquitin ligase,
Yuxiao Zheng +3 more
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Cryo-EM structure of the human COP1-DET1 ubiquitin ligase complex [PDF]
Nature CommunicationsUbiquitin modifications regulate fundamental cellular activities by modulating protein stability and function. The ubiquitin ligase COP1, which is present across species from plants to humans, plays a crucial role in the ubiquitination of developmental ...
Shan Wang +4 more
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Multi-omics analysis of patient-derived organoids reveals that E3 ligase COP1 promotes liver metastasis and oxaliplatin resistance in colorectal cancer through LUZP1 degradation and MYL9 phosphorylation [PDF]
Experimental Hematology & OncologyColorectal cancer liver metastasis (CRLM) and chemotherapy resistance remain major clinical challenges, with the underlying molecular mechanisms yet to be fully elucidated. In this study, based on analyses of five initial clinical cohorts from FUSCC, the
Ruijia Zhang +15 more
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COP1 Deficiency in BRAFV600E Melanomas Confers Resistance to Inhibitors of the MAPK Pathway [PDF]
CellsAberrant activation of the mitogen-activated protein kinase (MAPK) cascade promotes oncogenic transcriptomes. Despite efforts to inhibit oncogenic kinases, such as BRAFV600E, tumor responses in patients can be heterogeneous and limited by drug resistance
Ada Ndoja +16 more
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Inactivation of GH3.5 by COP1-mediated K63-linked ubiquitination promotes seedling hypocotyl elongation [PDF]
Nature CommunicationsCONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1), which was first discovered as a central repressor of photomorphogenesis in Arabidopsis, destabilizes proteins by ubiquitination in both plants and animals.
Yongting Liu +4 more
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Beyond HY5: COP1 Posttranslational Control of Anthocyanin Biosynthesis Proteins in Horticultural Crops [PDF]
PlantsAnthocyanins are widespread specialized metabolites that provide pigmentation and antioxidant capacity, contributing to pollinator and seed-disperser attraction and to plant resistance to diverse environmental stresses.
Gabriel Lasmar dos Reis +4 more
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Plant Communications, 2020 Green plants on the earth have evolved intricate mechanisms to acclimatize to and utilize sunlight. In Arabidopsis, light signals are perceived by photoreceptors and transmitted through divergent but overlapping signaling networks to modulate plant ...
Xue Han, Xi Huang, Xing Wang Deng
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